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9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL, MALEATE

9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL, MALEATE structure

CAS No:
118909-22-1
Formula:
C17H18N2O5
Chemical Name:
9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL, MALEATE
Synonyms:
HP-029;HYDROXYTACRINE MALEATE;HYDROXYTACRINE MALEATE SALT;9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDINE-1-(2H)-OL MALEATE;9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL, MALEATE;(±)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol, HP-029;Velnacrine maleate;Velnacrine maleate [usan]

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9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL, MALEATE Basic Attributes

Molecular Weight：

330.34

Exact Mass：

330.121582

UNII：

WR9885GALS|4401EF6U24

DSSTox ID：

DTXSID7045158

Color/Form：

Pale Beige to Beige

HScode：

2933998090

Characteristics

PSA：

133.74000

XLogP3：

2.47970

Melting Point：

171-173

Storage Conditions：

-20°C Freezer

Toxicity：

LD50 in mice (mg/kg): 136 orally; 162 i.p. (Shutske 1988, 1989)

Critical Temperature & Pressure：

Sealed in dry,2-8°C

Safety Information

hazard class code：

Marks：

Hazard note：

Toxic

Stability/Shelf Life：

Store in freezer at -20°C

Drug Information

MeSH：

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)

MeSH Entry Terms：

1,2,3,4-tetrahydro-9-aminoacridin-1-ol maleate

9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL, MALEATE Use and Manufacturing

A potential Alzheimer's Disease therapeutic of low toxicity. Exhibits biochemical and pharmacological profile similar to THA except that it is far less toxic and withoutmeasurable liver toxicity in humans.

Cholinesterase inhibitor. Potential Alzheimer's disease therapeutic

Computed Properties

Molecular Weight:330.33
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:330.12157168
Monoisotopic Mass:330.12157168
Topological Polar Surface Area:134
Heavy Atom Count:24
Complexity:377
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Guide of 9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL, MALEATE

Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL, MALEATE

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