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Home > Encyclopedia > 7-Amino-4-(trifluoromethyl)coumarin

7-Amino-4-(trifluoromethyl)coumarin

7-Amino-4-(trifluoromethyl)coumarin structure

7-Amino-4-(trifluoromethyl)coumarin 

structure
  • CAS No:

    53518-15-3

  • Formula:

    C10H6F3NO2

  • Chemical Name:

    7-Amino-4-(trifluoromethyl)coumarin

  • Synonyms:

    2H-1-Benzopyran-2-one,7-amino-4-(trifluoromethyl)-;7-Amino-4-(trifluoromethyl)-2H-1-benzopyran-2-one;Coumarin 151;7-Amino-4-(trifluoromethyl)coumarin;Coumarin 490;4-(Trifluoromethyl)-7-aminocoumarin;NSC 337981

  • Categories:

    Pharmaceutical Intermediates  >  Heterocyclic Compound

Description

7-Amino-4-(trifluoromethyl)coumarin (AFC, Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively.


7-amino-4-(trifluoromethyl)coumarin is a member of 7-aminocoumarins. It has a role as a fluorochrome.

7-Amino-4-(trifluoromethyl)coumarin Basic Attributes

229.16

229.16

4456797

258-599-1

337981

DTXSID0068862

2932209090

Characteristics

52.3

2.1

Yellow Powder

1.59 g/cm3

218.8 °C

314.6°C at 760 mmHg

144.1±27.9 °C

1.562

soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water.

Safety Information

IRRITANT

3

36/37/38-20/21/22

26-36-37/39

Xi,Xn

Irritant

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

H315

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

7-amino-4-trifluoromethylcoumarin

7-Amino-4-(trifluoromethyl)coumarin Use and Manufacturing

Uses

This dye is used to prepare peptidase substrates and for the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids.

2H-1-Benzopyran-2-one, 7-amino-4-(trifluoromethyl)-: ACTIVE

Computed Properties

Molecular Weight:229.15
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Exact Mass:229.03506292
Monoisotopic Mass:229.03506292
Topological Polar Surface Area:52.3
Heavy Atom Count:16
Complexity:337
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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