7-Amino-4-(trifluoromethyl)coumarin
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7-Amino-4-(trifluoromethyl)coumarin
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CAS No:
53518-15-3
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Formula:
C10H6F3NO2
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Chemical Name:
7-Amino-4-(trifluoromethyl)coumarin
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Synonyms:
2H-1-Benzopyran-2-one,7-amino-4-(trifluoromethyl)-;7-Amino-4-(trifluoromethyl)-2H-1-benzopyran-2-one;Coumarin 151;7-Amino-4-(trifluoromethyl)coumarin;Coumarin 490;4-(Trifluoromethyl)-7-aminocoumarin;NSC 337981
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CAS No:
Description
7-Amino-4-(trifluoromethyl)coumarin (AFC, Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively.
7-amino-4-(trifluoromethyl)coumarin is a member of 7-aminocoumarins. It has a role as a fluorochrome.
7-Amino-4-(trifluoromethyl)coumarin Basic Attributes
229.16
229.16
4456797
258-599-1
337981
DTXSID0068862
2932209090
Characteristics
52.3
2.1
Yellow Powder
1.59 g/cm3
218.8 °C
314.6°C at 760 mmHg
144.1±27.9 °C
1.562
soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water.
Safety Information
IRRITANT
3
36/37/38-20/21/22
26-36-37/39
Xi,Xn
Irritant
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
7-Amino-4-(trifluoromethyl)coumarin Use and Manufacturing
This dye is used to prepare peptidase substrates and for the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids.
2H-1-Benzopyran-2-one, 7-amino-4-(trifluoromethyl)-: ACTIVE
Computed Properties
Molecular Weight:229.15
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Exact Mass:229.03506292
Monoisotopic Mass:229.03506292
Topological Polar Surface Area:52.3
Heavy Atom Count:16
Complexity:337
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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7-Amino-4-(trifluoromethyl)coumarin
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