CALPAIN INHIBITOR II

N-Acetylleucyl-leucyl-methioninal is a peptide.

white to off-white powder

A cell-permeable inhibitor of calpain I (Ki= 120 nM), calpain II (Ki= 230 nM), cathepsin B (Ki= 100 nM), and cathepsin L (Ki= 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Molecular Weight:401.6
XLogP3:2.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:13
Exact Mass:401.23482778
Monoisotopic Mass:401.23482778
Topological Polar Surface Area:130
Heavy Atom Count:27
Complexity:497
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes