Reboxetine mesylate
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Reboxetine mesylate
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CAS No:
98769-84-7
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Formula:
C19H23NO3.CH4O3S
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Chemical Name:
Reboxetine mesylate
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Synonyms:
Morpholine,2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-,(2R)-rel-,methanesulfonate (1:1);Morpholine,2-[(2-ethoxyphenoxy)phenylmethyl]-,(R*,R*)-(±)-,methanesulfonate;Morpholine,2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-,(2R)-rel-,methanesulfonate;FCE 20124;Reboxetine mesylate;PNU 155950E;Edronax;Davedax;PNU 155905E;(±) Reboxetine mesylate;Reboxetine mesilate;98769-82-5;141425-90-3
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CAS No:
Description
Reboxetine Mesylate is a norepinephrine reuptake inhibitor use in the treatment of unipolar depression.Target: OthersReboxetine is a drug of the norepinephrine reuptake inhibitor class. Reboxetine dose-dependently and potently inhibits locus coeruleus neuronal firing in rats with ED50 of 191 μg/kg. Reboxetine inhibition of the locus coeruleus neurons is reversible by the α2 antagonist piperoxan (1.5 mg/kg, IV). Reboxetine dose-dependently reverses reserpine-induced blepharospasm and hypo
A morpholine derivative that is a selective and potent noradrenaline reuptake inhibitor; it is used in the treatment of DEPRESSIVE DISORDER.
Characteristics
103
4.10740
tan or off-white amorphous semi-solid
148.4-149.1 °C
443.7°C at 760 mmHg
188.2ºC
H2O: ~8 mg/mL at ≤60 °C
2-8°C
Safety Information
3
22-24/25
P201, P202, P260, P263, P264, P270, P281, P301+P312, P308+P313, P314, P330, P405, P501
H302
Drug Information
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)|Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)
2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate
Reboxetine mesylate Use and Manufacturing
A selective noradrenaline reuptake inhibitor. Antidepressant.
Computed Properties
Molecular Weight:409.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:409.15590875
Monoisotopic Mass:409.15590875
Topological Polar Surface Area:103
Heavy Atom Count:28
Complexity:425
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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