4-IODO-2-FLUORO-3-FORMYLPYRIDINE
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4-IODO-2-FLUORO-3-FORMYLPYRIDINE
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CAS No:
153034-82-3
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Formula:
C6H3FINO
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Chemical Name:
4-IODO-2-FLUORO-3-FORMYLPYRIDINE
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Synonyms:
2-FLUORO-4-IODONICOTINALDEHYDE;2-FLUORO-4-IODOPYRIDINE-3-CARBOXALDEHYDE;4-IODO-2-FLUORO-3-FORMYLPYRIDINE;2-FLUORO-3-FORMYL-4-IODOPYRIDINE;2-Fluoro-4-iodo-3-pyridinecarboxaldehyde;2 - F -3 - aldehyde -4 - iodine pyridine;2-fluoro-4-iodonicotaldehyde;2-Fluoro-4-iodopyridine-3-carbaldehyde
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CAS No:
Characteristics
30
1.4
2.081±0.06 g/cm3(Predicted)
304.2±42.0 °C(Predicted)
137.8±27.9 °C
1.650
Room temperature.
Safety Information
22
Xi,Xn
Irritant
|Warning|H302 (75%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4-IODO-2-FLUORO-3-FORMYLPYRIDINE Use and Manufacturing
To a solution of diisopropylamine (174.4g, 1 .73 mol) in dry THF (3 L) was added dropwise 2.5 M solution of n-BuLi in hexane (685 mL, 1 .71 mol) at -10°C. The resulting mixture was stirred at 0°C for 35 min. The mixture was cooled to -70°C and a solution of 2-fluoro-3-iodopyridine (I-26) (350 g, 1 .57 mol) in dry THF (1 L) was added. The mixture was stirred at -70°C for 2 hr. HCOOEt (128 g, 1 .73 mol) was added dropwise at -70°C. After the addition, the mixture was allowed to warm to room temperature and quenched with ice water (4 L). The mixture was diluted with EtOAc (4 L) and washed with brine (500 mL). The organic layer was dried over Na2S04 and concentrated in vacuo. The residue was purified by silica gel chromatography eluted with petroleum:EtOAc = 10:1 to afford 2-fluoro-4-iodonicotinaldehyde (I-27) (180 g, 46percent) as a yellow solid.1H NMR (400 MHz, CDCI3) δ ppm 10.08 (s, 1 H), 7.91 (d, 1 H), 7.81 (d, 1 H).
Computed Properties
Molecular Weight:251.00
XLogP3:1.4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:250.92434
Monoisotopic Mass:250.92434
Topological Polar Surface Area:30
Heavy Atom Count:10
Complexity:133
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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Business licensedTrader Supplier of pharmaceutical intermediates,excipients,plant extracts,food additives,CDMO,fine cheimcals,Octadecanedioic acid,Eicosanedioic AcidInquiryCAS No.: 153034-82-3Grade: Pharmaceutical GradeContent: 99% -
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4-IODO-2-FLUORO-3-FORMYLPYRIDINE
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