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Empagliflozin

Empagliflozin structure

CAS No:
864070-44-0
Formula:
C23H27ClO7
Chemical Name:
Empagliflozin
Synonyms:
D-Glucitol,1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-,(1S)-;(1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol;Empagliflozin;BI 10773;Jardiance;1240076-01-0;1314556-33-6
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

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Description

Empagliflozin is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2.

Empagliflozin Basic Attributes

Molecular Weight：

450.909

Exact Mass：

450.91

Characteristics

PSA：

108.61000

XLogP3：

Density：

1.4±0.1 g/cm3

Boiling Point：

664.5±55.0 °C at 760 mmHg

Flash Point：

355.7±31.5 °C

Refractive Index：

1.628

Safety Information

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H361

Empagliflozin Use and Manufacturing

Empagliflozin is a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats.

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Empagliflozin Tablets (Otangjing)
Specifications	10mg*10s

Empagliflozin Tablets
Ingredients	Active ingredient: Empagliflozin. Chemical name: (1S)-1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol. Chemical structure: Molecular formula: C23H27ClO7 Molecular weight: 450.9
Indication	Diuretics Empagliflozin co-administered with diuretics may result in increased urine volume and urinary frequency, which may increase the risk of hypovolemia (see [Precautions]). Insulin or insulin secretagogues Empagliflozin co-administered with insulin or insulin secretagogues may increase the risk of hypoglycemia (see [Precautions]). Positive urine glucose test It is not recommended to monitor blood glucose control by urine glucose test in patients taking SGLT2 inhibitors, because SGLT2 inhibitors increase urine glucose excretion and will result in positive urine glucose test results. Use other methods to monitor blood glucose control. Interference with 1,5-anhydroglucose (1,5-AG) assay It is not recommended to monitor blood glucose control using 1,5-AG assay, because blood glucose control cannot be reliably assessed by measuring 1,5-AG in patients taking SGLT2 inhibitors. Use other methods to monitor blood glucose control.
Specifications	10mg x 10 tablets

Registered Holders

AZICO BIOPHORE INDIA PRIVATE LTD

United States
Active
MANKIND PHARMA LTD

United States
Active
METROCHEM API PRIVATE LTD

United States
Active

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