Sodium diacetate

142.086

142.024

204-823-8

NVG71ZZ7P0

0565

DTXSID2027044|DTXSID7041124

C48017

WHITE GRANULAR POWDER OR MONOCLINIC CRYSTALS|Colorless

B - Blood and blood forming organs

2915291000

77.43

-1.15290

solid

1.5285 g/cm3

323-329 °C(lit.)

117.1ºC at 760 mmHg

40ºC

INDEX OF REFRACTION: 1.464

WATER: 119 G/100 ML @ 0 °C, 170.15 G/100 ML @ 100 °C; SLIGHTLY SOL IN ALCOHOL

2-8ºC

Odorless

8,0-9,5 (1 % aqueous solution)

HYGROSCOPIC|COLORLESS, TRANSPARENT CRYSTALS OR GRANULAR, CRYSTALLINE POWDER; ODORLESS OR HAS FAINT, ACETOUS ODOR. /SODIUM ACETATE TRIHYDRATE, USP/|SOL: 76.2 G/100 ML WATER AT 0 °C; 138.8 G/100 ML WATER @ 50 °C; 2.1 G/100 ML ALC AT 18 °C; SOL IN ETHER; INDEX OF REFRACTION: 1.464 (BETA); DENSITY 1.45 G/ML; MP 58 °C; COLORLESS MONOCLINIC PRISMS. /SODIUM ACETATE TRIHYDRATE/

1125 °F /SODIUM ACETATE TRIHYDRATE/|607 °C

UN 2790 8/PG 2

1

R35

S24/25-S45-S26-S23

AJ4375000

C

SOLUTIONS ARE STABLE; EFFLORESCES IN WARM, DRY AIR /SODIUM ACETATE TRIHYDRATE, USP/

Violent reaction with flourine and potassium nitrate, diketene.

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).|The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl sodium acetate, approved on the basis of safety and effectiveness by FDA under sections 505 and 507 of the Federal Food, Drug, and Cosmetic Act.|Substances migrating to food from cotton and cotton fabrics used in dry food packaging that are generally recognised as safe for their intended use include sodium acetate.|Substance added directly to human food affirmed as generally recognized as safe (GRAS) when in compliance with specified requirements.|Sodium acetate used as a general purpose food additivin animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Combustible.

Not Classified

Use water spray, foam, powder, carbon dioxide.

Combustible

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

Dry. Separated from strong acids and strong oxidants.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached.

The substance is mildly irritating to the eyes and skin.

NO open flames.

Use local exhaust.

Protective gloves.

Wear safety goggles.

LD50: 25956 mg/kg (Rat.)

ITS ORAL USE SPEEDS METABOLISM OF & LOWERS ETHYL ALCOHOL LEVEL IN RATS' BLOOD.|IV SODIUM ACETATE DID NOT REVERSE MYOCARDIAL DEPRESSION INDUCED BY HALOTHANE WHEN ADMIN TO DOGS. ACETATE, A WELL-ESTABLISHED PERIPHERAL VASCULAR VASODILATOR, DID DECR LEFT VENTRICULAR & AORTIC PRESSURES.

LD50 Rat oral 3500 mg/kg|LD50 Mouse oral 4960 mg/kg

Injection, USP 40 mEq is indicated as a source of sodium, for addition to large volume intravenous fluids to prevent or correct hyponatremia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions. Sodium acetate and other bicarbonate precursors are alkalinising agents, and can be used to correct metabolic acidosis, or for alkalinisation of the urine.|Parenteral nutrition

Diuretics; Expectorants; Pharmaceutic Aids|/FORMER USE/: HYOSCYAMUS SODIUM ACETATE, & PHENOBARBITAL ELIXIR COMBINES SMOOTH MUSCLE ANTISPASMODIC ACTION OF ... HYOSCYAMUS, WITH URINARY ALKALINIZING & DIURETIC EFFECTS OF SODIUM ACETATE, & SEDATIVE EFFECTS OF PHENOBARBITAL. /IT IS/ USED IN MANAGEMENT OF CYSTITIS & FOR BLADDER IRRITATION.|DOSAGE OF ELIXIR OF HYOSCYAMUS CMPD /CONTAINING SODIUM ACETATE & PHENOBARBITAL/ IS 5 ML GIVEN 3 TIMES DAILY BEFORE MEALS.|... /SODIUM ACETATE/ HAS BEEN USED FOR PARENTERAL THERAPY OF ACIDOTIC CONDITIONS. IT IS BOTH A SYSTEMIC & URINARY ALKALIZER. /SODIUM ACETATE TRIHYDRATE, USP/|For more Therapeutic Uses (Complete) data for SODIUM ACETATE (8 total), please visit the HSDB record page.

Sodium is the principal cation of extracellular fluid. It comprises more than 90% of total cations at its normal plasma concentration of approximately 140 mEq/liter. The sodium ion exerts a primary role in controlling total body water and its distribution. Acetate ions acts as hydrogen ion acceptor which is alternative to bicarbonate.

It is readily available in the circulation after IV administration.|Both the sodium and bicarbonate ions are excreted mainly in the urine. Some sodium is excreted in the feces, and small amounts may also be excreted in saliva, sweat, bile and pancreatic secretions.

In liver, sodium acetate is being metabolized into bicarbonate. To form bicarbonate, acetate is slowly hydrolyzed to carbon dioxide and water, which are then converted to bicarbonate by the addition of a hydrogen ion.|THE ACETATE ION IS RAPIDLY & COMPLETELY METABOLIZED BY BODY, & CONSEQUENTLY ADMIN OF SODIUM ACETATE IS EVENTUALLY EQUIVALENT TO GIVING SODIUM BICARBONATE. /SODIUM ACETATE TRIHYDRATE, USP/|CONSTANT RATE INFUSIONS OF SODIUM ACETATE GIVEN TO VOLUNTEERS, AT 4 MMOL/KG/HR INCR PLASMA ACETATE BY ONLY 0.41 MMOL/L, INDICATING A HIGH ACETATE METABOLIZING CAPACITY IN MAN.|Readily metabolized outside the liver.

It works as a source of sodium ions especially in cases of hyponatremic patients. Sodium has a primary role in regulating extracellular fluid volume. It controls water distribution, fluid and electrolyte balance and the osmotic pressure of body fluids. Sodium is also involved in nerve conduction, muscle contraction, acid-base balance and cell nutrient uptake.

Because of demanding reagent,pharmaceutical, medical, and photographic uses, purity becomes very important. Among improvements made in recent years were the reduction of iron content and carbonate level of the Food Chemical Codex grade. Technical grades have higher limits for heavy metals, arsenic, carbonates, or potassium compounds.

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

SISTER CHROMATID EXCHANGE - IN VITRO CHROMOSOMAL EFFECT STUDIES, HUMAN: NEGATIVE.|Acetate is the primary breakdown product of ethanol metabolism in the liver. ... Systemically administered acetate has been shown to cause motor impairment, an effect which is blocked by the adenosine receptor blocker, 8-phenyltheophylline. The effects of sodium acetate were investigated using intracellualr recording techniques in rat hippocampal dentate granule cells, and were compared to the actions of ethanol and adenosine individually and in conjunction with 8-phenyltheophylline. Acetate hyperpolarized the membrane of 0.4-0.8 mM. The amplitude and duration of the postspike train after hyperpolarization were increased by acetate when the cell was repolarized to the control resting membrane potential. Comparable results were seen in voltage clamp. Acetate also decreased spike frequency adaptation. The effects of acetate were mimicked by adenosine (50 uM) and ethanol (20 mM). The ethanol effects occluded those produced by acetate. All of the effects of acetate, adenosine and ethanol could be inhibited with prior perfusion of 8-phenyltheophylline (1-10 uM). These data suggest that the actions of the major metabolite of ethanol, acetate, and adenosine may be mediated by adenosine receptor activation.

Sodium Acetate

The substance can be absorbed into the body by ingestion.

Redness.

Redness.

Textile, Leather, Dyestuff & Chemical Intermediate, 75%; Misc, 25% (1983)

GRADES: HIGHEST PURITY; PURE FUSED; CP; NF; TECHNICAL; FCC|There are several commercial grades of sodium acetate. Anhydrous 99.0% purity is available as technical, USP and photo grade. Photo grade has a more narrow particle size distribution and the particle density is greater and more uniform. Sodium acetate 60% is available as technical, NF, and Food Chemicals Codex. In the form of clean fine crystals, this trihydrate contains about 40% water of crystallization. Commercial solutions, 33%, are also available|Generic solution 2 mEq/ml in 20, 50, and 100 ml containers and 4 mEq/ml in 50 and 100 ml containers.

All other basic inorganic chemical manufacturing|Acetic acid, sodium salt (1:1): ACTIVE|... /SODIUM ACETATE/ OFFERS NO REAL ADVANTAGE OVER BICARBONATE SOLN EXCEPT THAT IT IS CHEAPER & CAN BE STORED FOR LONGER PERIODS IN HOT CLIMATES.|IT IS A SUBSTANCE WHICH MIGRATES TO FOOD FROM PACKAGING MATERIALS.|... SODIUM ACETATE OINTMENT HAS PH OF 5 ... ABOUT SAME ACIDITY AS NORMAL SKIN. IT IS SOOTHING, PROTECTIVE OINTMENT WHICH MAY BE USED IN PLACE OF BORIC ACID OINTMENT.

SODIUM ACETATE IN COLOR ADDITIVES DETERMINED BY TITRATION METHOD.|NIOSH Method: 173. Analyte: Sodium. Matrix: Air. Procedure: Atomic absorption spectrophotometry. This method has a detection limit of 0.0002 and sensitivity of 0.015 ug/ml. The working range for a precision better than 3% RSD/CV is 0.05-1.0 ug/ml. Interference: Spectral, ionization, chemical and physical interferences. /Sodium/|NIOSH Method: 7300. Analyte: Sodium. Matrix: Air. Procedure: Inductively coupled argon plasma, atomic emission spectroscopy. For sodium this method has an estimated detection limit of 10 ng/ml sample. The precision/RSD and the recovery are not determined. Applicability: The working range of this method is 0.005 to 2.0 mg/cu m for each element in a 500 liter air sample. Interferences: Spectral interferences. /Sodium/|Method 3111-Metals A. Direct Aspiration Atomic Absorption Spectrometry is used for the determination of sodium in water and wastewater. Using air/acetylene as the flame gas at a wavelength of 589.0 nm, the detection limit is 0.002 mg/l, with a sensitivity of 0.015 mg/l, at an optimum concentration range of 0.03-1 mg/l. /Sodium/|For more Analytic Laboratory Methods (Complete) data for SODIUM ACETATE (6 total), please visit the HSDB record page.

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Food additives|Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Food Additives -> ACIDITY_REGULATOR; -> JECFA Functional Classes|Cosmetics -> Buffering

Food Additives -> ACIDITY_REGULATOR;