Monosodium glutamate

169.111

169.035

205-538-1|269-085-1|240-733-5|240-313-1

H0US799L9M

DTXSID9020906

White free flowing crystals or crystalline powder|Forms rhombic prisms when crystallized from water

2922422000

103.45

-1.37130

White crystal powder

26.2 (saturated water solution at 20 °C)

232°C

333.8ºC at 760 mmHg

155.7ºC

25 ° (C=10, 2mol/L HCl)

H2O: >=10 g/100 mL at 20 ºC

Keep tightly closed in a cool place in a tightly closed container.

2.55E-05mmHg at 25°C

Practically odorless

Meaty taste comes from contaminants in crude glutamates; sweet-saline taste in large concn; no flavor in small quantity|A 1% concn or more is liable to produce a sweetish taste.

THE MONOHYDRATE FORMS NEEDLES|THE FLAVOR BECOMES PERCEPTIBLE @ A CONCN OF 0.03% IN DISTILLED WATER|Below -8 deg /C/, it crystallizes as a pentahydrate, which, after filtration and exposure to air, loses water of crystallization and becomes the monohydrate.

Water soluble.

Salts, Acidic

Acidic salts, such as MONOSODIUM GLUTAMATE, are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

2

R20/21/22

MA1578000

Stable.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Glutamate is commonly found in food, primarily from protein sources. Foods and ingredients that contain glutamate as an inherent component are not required to list glutamate on the label. ...When MSG is added to food the FDA requires "monosodium glutamate" to be listed on the label. Other salts of glutamic acid--such as monopotassium glutamate and monoammonium glutamate--also have to be declared on labels and cannot be lumped together under "spices," "natural flavoring" or other general terms.|It is impracticable to list all substances that are generally recognized as safe for their intended use. However, by way of illustration, the Commissioner regards such common food ingredients as salt, pepper, vinegar, baking powder, and monosodium glutamate as safe for their intended use.

WHO Food Additive Series 22; L-Glutamic Acid and its Ammonium, Calcium, Monosodium and Potassium Salts (1988). Available at http://www.inchem.org/documents/jecfa/jecmono/v22je12.htm as of March 20, 2007. These substances were evaluated at the 14th, 17th, and 22nd meetings of the Joint Expert Committee on Food Additives (JECFA). Information in this monograph summarized and incorporates all information available to the 22nd committee.|European Chemicals Bureau; IUCLID Dataset, Sodium Hydrogen Glutamate (CAS No.142-47-2). Available from the database query page: http://ecb.jrc.it/esis/esis.php as of January 22, 2007.|Zautcke JL et al; Chinese Restaurant Syndrome, Ann Emerg Med 15 (10): 1210-3 (1986).

Flash point data are not available for this chemical, but it is probably combustible. (NTP, 1992)

Not Classified| |Warning|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 29 companies from 2 notifications to the ECHA C&L Inventory.|Aggregated GHS information provided by 182 companies from 3 notifications to the ECHA C&L Inventory.

Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

L-Glutamic acid and its ammonium, calcium, monosodium and potassium salts were evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 1988. The Committee noted that intestinal and hepatic metabolism results in elevation of levels in systemic circulation only after extremely high doses given by gavage (>30mg/kg body weight). Ingestion of monosodium glutamate (MSG) was not associated with elevated levels in maternal milk, and glutamate did not readily pass the placental barrier. Human infants metabolized glutamate similarly to adults. Conventional toxicity studies using dietary administration of MSG in several species did not reveal any specific toxic or carcinogenic effects nor were there any adverse outcomes in reproduction and teratology studies. Attention was paid to central nervous system lesions produced in several species after parenteral administration of MSG or as a consequence of very high doses by gavage. Comparative studies indicated that the neonatal mouse was most sensitive to neuronal injury; older animals and other species (including primates) were less so. Blood levels of glutamate associated with lesions of the hypothalamus in the neonatal mouse were not approached in humans even after bolus doses of 10 g MSG in drinking water. Because human studies failed to confirm an involvement of MSG in "Chinese Restaurant Syndrome" or other idiosyncratic intolerance, the JECFA allocated an "acceptable daily intake (ADI) not specified" to glutamic acid and its salts. No additional risk to infants was indicated. The Scientific Committee for Food (SCF) of the European Commission reached a similar evaluation in 1991. The conclusions of a subsequent review by the Federation of American Societies for Experimental Biology (FASEB) and the Federal Drug Administration (FDA) did not discount the existence of a sensitive subpopulation but otherwise concurred with the safety evaluation of JECFA and the SCF.

Monosodium glutamate (MSG) administered intraperitoneally /for 10 days/ at a dose of 4 mg/g bw markedly increase malondialdehyde (MDA) formation in the liver, the kidney and brain of rats. Simultaneous administration of VIT C, VIT E and quercetin to MSG-treated rats significantly reduced this increase in MDA induced by MSG. VIT E reduced lipid peroxidation mostly in the liver followed by VIT C and then quercetin, while VIT C and quercetin showed a greater ability to protect the brain from membrane damage than VIT E. The decreased glutathione (GSH) level elicited by MSG in the three organs corresponded with marked increase in the activity of glutathione-S-transferase (GST). While MSG increased (p < 0.001) the activities of superoxide dismutase and catalase in the liver, it decreased significantly the activities of these enzymes in the kidney and the brain. The three antioxidants were effective at ameliorating the effects of MSG on GSH levels and the enzymes in the three organs examined. While MSG increased the activity of glucose-6-phosphatase in the liver and kidneys of rats (p < 0.001), the activity of the enzyme was abysmally low in the brain. There were marked increases in the activities of alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase in rats treated with MSG. The antioxidants tested protected against MSG-induced liver toxicity significantly. MSG at a dose of 4 mg/g significantly (p < 0.01) induced the formation of micronucleated polychromatic erythrocytes (MNPCEs). Co-treatment of rats with VIT C and quercetin inhibited the induction of MNPCEs by MSG (p < 0.001) ...

LD50 Rat female oral 15800 mg/kg bw|LD50 Rat male oral 17300 mg/kg/day|LD50 Mouse male oral 17700 mg/kg bw|LD50 Mouse female oral 16400 mg/kg bw|For more Non-Human Toxicity Values (Complete) data for MONOSODIUM GLUTAMATE (24 total), please visit the HSDB record page.

/PLANTS/ To make a comprehensive assessment on monosodium glutamate wastewater pollution, a pollution exposure experiment was carried out on the seed germination and root elongation of wheat, Chinese cabbage and tomato by using the wastewater discharged from different processing phases of monosodium glutamate production. The results showed that there were significantly positive linear relationships between the inhibition rates of wheat seed germination and root elongation and the COD(Cr) of mother liquor scraps. The toxicity of monosodium glutamate wastewater to the test crops was in the order of tomato > Chinese cabbage > wheat, indicating that tomato was most sensitive to the wastewater, and could be considered as an ideal toxic bioindicator. The half-effect concentration (IC50) based on the seed germination and root elongation of test crops exposed to the wastewater discharged from various processing phases of monosodium glutamate production was 22.0 to approximately 32432 mg/L and 17.3 to approximately 3320 mg/L, respectively.

Monosodium glutamate tested negative in mutagenicity studies with Salmonella typhimurium strains TA97, TA98, TA100, TA1535 in the presence or absence of 10 or 30% of S9 in the S9 mixture (metabolic activation enzymes and cofactors from Aroclor 1254-induced male Sprague-Dawley rat or Syrian hamster liver) that was added to cultures. /From table/

The FASEB report identifies two groups of people who may develop a condition the report refers to as "MSG symptom complex." One group is those who may be intolerant to MSG when eaten in a large quantity. The second is a group of people with severe, poorly controlled asthma. These people, in addition to being prone to MSG symptom complex, may suffer temporary worsening of asthmatic symptoms after consuming MSG. The MSG dosage that produced reactions in these people ranged from 0.5 grams to 2.5 grams.|Biochemical evidence for the deficiency of vitamin B6 is given for subjects reacting to monosodium l-glutamate

Sodium salt of glutamic acid, one of the common naturally occurring amino acids.

Monosodium glutamate's production and use as a food additive(1), may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 4(SRC), determined from a water solubility of 3.85X10+5 mg/L(2) and a regression-derived equation(3), indicates that monosodium glutamate is expected to possess very high mobility in soil(SRC). Volatilization will not be an important fate process because salts do not volatilize. Monosodium glutamate degraded rapidly using marine water/sediment and estuarine water/sediment microcosms(4), suggesting biodegradation will occur readily in soil.|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 4(SRC), determined from a water solubility of 3.85X10+5 mg/L(2) and a regression-derived equation(3), indicates that monosodium glutamate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization in water will not be an important fate process because monosodium glutamate will form the sodium and glutamate ions in water which do not volatilize. According to a classification scheme(4), an estimated BCF of 1(SRC), from the water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Monosodium glutamate degraded rapidly using marine water/sediment and estuarine water/sediment microcosms(5).|ATMOSPHERIC FATE: Monosodium glutamate is the sodium salt of glutamic acid and will exist in the particulate phase if released to the atmosphere. Particulate-phase monosodium glutamate may be removed from the air by wet or dry deposition. (SRC)

Monosodium glutamate is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(1). Monosodium glutamate does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(1).

An estimated BCF of 1 was calculated in fish for monosodium glutamate(SRC), using a water solubility of 3.85X10+5 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of monosodium glutamate is estimated as 4(SRC), using a water solubility of 3.85X10+5 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that monosodium glutamate is expected to have very high mobility in soil.

Monosodium glutamate is the monosodium salt of glutamic acid(1). Volatilization from soil and water surfaces will not be an important environmental fate process since salts do not volatilize(SRC).

Monosodium glutamate is used in large quantities as a flavor enhancer throughout the world(1). Monosodium glutamate was identified in 502 food products in a National Food Survey conducted in the UK in 1990(2). The mean percentage of monosodium glutamate contained in the various food items ranged from 0.06% in cured pork to 8.7% in meat and yeast extracts(2).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 60,341 workers (22,829 of these are female) are potentially exposed to monosodium glutamate in the US(1). Occupational exposure to monosodium glutamate may occur through dermal contact with this compound at workplaces where monosodium glutamate is produced or used(SRC). The general population is exposed to monosodium glutamate primarily via ingestion of food products containing this additive(SRC).

One of the FLAVORING AGENTS used to impart a meat-like flavor. Medically it has been used to reduce blood ammonia levels in ammoniacal azotemia, therapy of hepatic coma, in psychosis, and mental retardation.

The large doses of sodium glutamate required for the treatment of hepatic encephalopathy may result in dangerous alkalosis and hypokalemia ... important to keep close control on the electrolyte balance during therapy.|Injections of sodium glutamate should be given with caution to patients with hepatic cirrhosis, impaired renal function, or liver disease not associated with hyperammonemia.|Food and Environmental Agents: Effect on Breast-Feeding: Monosodium glutamate: None. /from Table 7/

Substances added to foods and medicine to improve the taste. (See all compounds classified as Flavoring Agents.)

Glutamate is absorbed from the gut by an active transport system specific for amino acids. This process is saturable, can be competitively inhibited, and is dependent on sodium ion concentration... . During intestinal absorption, a large proportion of glutamic acid is transaminated and consequently alanine levels in portal blood are elevated. If large amounts of glutamate are ingested, portal glutamate levels increase ... . This elevation results in increased hepatic metabolism of glutamate, leading to release of glucose, lactate, glutamine, and other amino acids, into systemic circulation ... . The pharmacokinetics of glutamate depend on whether it is free or incorporated into protein, and on the presence of other food components. Digestion of protein in the intestinal lumen and at the brush border produces a mixture of small peptides and amino acids; di-and tri-peptides may enter the absorptive cells where intracellular hydrolysis may occur, liberating further amino acids. Defects are known in both amino acid and peptide transport ... .. Glutamic acid in dietary protein, together with endogenous protein secreted into the gut, is digested to free amino acids and small peptides, both of which are absorbed into mucosal cells where peptides are hydrolyzed to free amino acids and some of the glutamate is metabolized. Excess glutamate and other amino acids appear in portal blood. As a consequence of the rapid metabolism of glutamate in intestinal mucosal cells and in the liver, systemic plasma levels are low, even after ingestion of large amounts of dietary protein. /Glutamic acid/|... Intestinal and hepatic metabolism results in elevation of levels in systemic circulation only after extremely high doses given by gavage (>30mg/kg body weight). Ingestion of monosodium glutamate (MSG) was not associated with elevated levels in maternal milk, and glutamate did not readily pass the placental barrier. Human infants metabolized glutamate similarly to adults.|Oral administration of pharmacologically high doses of glutamate results in elevated plasma levels. The peak plasma glutamate levels are both dose and concentration dependent ... . When the same dose (1 g/kg b.w.) of monosodium glutamate (MSG) was administered by gavage in aqueous solution to neonatal rats, increasing the concentration from 2% to 10% caused a five-fold increase in the plasma area under curve; similar results were observed in mice ... . Conversely, when MSG (1.5 g/kg b.w.) was administered to 43-day-old mice by gavage at varying concentrations of 2 to 20% w/v, no correlation could be established between plasma levels and concentration ...|Administration of a standard dose of 1 g/kg b.w. MSG by gavage as a 10% w/v solution resulted in a marked increase of plasma glutamate in all species studied. Peak plasma glutamate levels were lowest in adult monkeys (6 times fasting levels) and highest in mice (12-35 times fasting levels). Age-related differences between neonates and adults were observed; in mice and rats, peak plasma levels and area under curve were higher in infants than in adults while in guinea pigs the converse was observed.|For more Absorption, Distribution and Excretion (Complete) data for MONOSODIUM GLUTAMATE (7 total), please visit the HSDB record page.

Glutamic acid is metabolized in the tissues by oxidative deamination ... or by transamination with pyruvate to yield oxaloacetic acid ... which, via alpha-ketoglutarate, enters the citric acid cycle ... .. Quantitatively minor but physiologically important pathways of glutamate metabolism involve decarboxylation to gamma-aminobutyrate (GABA) and amidation to glutamine ... . Decarboxylation to GABA is dependent on pyridoxal phosphate, a coenzyme of glutamic acid decarboxylase ..., as is glutamate transaminase. Vitamin B6-deficient rats have elevated serum glutamate levels and delayed glutamate clearance ... . /Glutamic acid/|Oral dose of 1 g/kg monosodium glutamate given to rats was followed by only a small rise in plasma pyroglutamate levels. No incr of pyroglutamate or glutamate brain levels was observed under these conditions.

L-Glutamate and GABA supposedly act as excitatory and inhibitory transmitters, respectively, in the central nervous system. Glutamate is also involved in the synthesis of proteins. /Glutamate/

Monosodium glutamate is contaminated by sodium chloride, but as a food flavoring material this is generally of no consequence.|Limits of impurities: Chlorides, 0.2%; Arsenic, 3 ppm (as As); Heavy metals, 20 ppm; Lead, 10 ppm

SYMPTOMS: Large oral doses in humans have provoked burning sensation, facial pressure, chest pains, dyspnea, somnolence, hallucinations, distorted perceptions, nause and vomiting. Susceptible individuals may experience an allergic response. ACUTE/CHRONIC HAZARDS: This compound emits toxic fumes when heated to decomposition. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

/SRP Idiosyncratic reaction/: No decontamination measures have been reported. No antidotes exist. Supportive measures: Follow with ECG and cardiac evaluation if chest pain persists. Alert patient to avoid foods with MSG.

/HUMAN EXPOSURE STUDIES/ ... A high dose of 2.5 g was tested in 6 healthy controls and 30 asthmatics (7: allergic asthma; 15: intrinsic asthma with intolerance to aspirin; 8: intrinsic asthma with aspirin intolerance, intolerance to alcohol or to food additives). Two patients presented with a mild bronchospasm, occurring 6 to 10 hours after the ingestion. Different mechanisms are discussed. A cholinergic mechanism might be incriminated, either due to stimulation of the synthesis of acetylcholine, or due to a vagal reflex elicited by a reflux esophagitis. However, a high vagal hyperreactivity seems to be needed for the occurrence of asthma. It is concluded that a very small subset of patients with intrinsic asthma might present with an intolerance to monosodium glutamate if high doses are consumed.|/HUMAN EXPOSURE STUDIES/ Monosodium glutamate is widely regarded as the provocative agent in the "Chinese restaurant syndrome," of which flushing is regarded as part of the reaction. Six subjects were monitored by laser Doppler velocimetry for changes in facial cutaneous blood flow during challenge with monosodium glutamate and its cyclization product, pyroglutamate. Additionally, records of patients challenged with monosodium glutamate in the laboratory were reviewed. No flushing was provoked among the twenty four people tested, eighteen of whom gave a positive history of Chinese restaurant syndrome flushing. These results indicate that monosodium glutamate provoked flushing, if it exists at all, must be rare. Monosodium glutamate and its cyclization product, pyroglutamate, may provoke edema and associated symptoms.|/HUMAN EXPOSURE STUDIES/ /The objective of this study was/ to determine whether monosodium glutamate (MSG) would induce bronchoconstriction in a group of adults with asthma who perceived that they were MSG sensitive. Twelve subjects (seven women, mean age 35.3 years) with clinically documented asthma and a perception of MSG-induced asthma were recruited. FEV1 and peak expiratory flow data were obtained for 3 whole control days, as well as time-matched data for 3 separate challenge days (1 g MSG, 5 g MSG, and 5 g lactose [placebo]). Opaque capsule challenges were given as a single dose in the morning after an overnight fast. Subjects complied with an elimination diet throughout the study. Nonspecific bronchial hyperresponsiveness was measured at baseline, after the control days, and at the conclusion of the challenges. Venous blood samples were taken at baseline and on each challenge day to determine soluble inflammatory marker (eosinophil cationic protein and tryptase) activity. No immediate or definite late asthmatic reactions occurred. One subject's FEV1 declined more than 15% on MSG challenge, but 95% confidence limits for the control-day spirometry showed that this decline was within her daily variation. ... No significant changes in bronchial hyperresponsiveness or soluble inflammatory markers were found.|/HUMAN EXPOSURE STUDIES/ This study sought to determine the prevalence of reactions to additives, including monosodium glutamate (MSG), in patients with chronic urticaria using a rigorous protocol. Sixty-five subjects (44 women, 21 men; ages 14-67) /were studied/. All had urticaria for >6 wk without discernible etiology. Subjects with active urticaria were studied while they were taking the lowest effective dose of antihistamine. Screening challenges to the 11 additives most commonly associated with exacerbations of chronic idiopathic urticaria were performed in a single-blind fashion. The dose of MSG given was 2500 mg. Skin scores were obtained to determine a positive reaction in an objective manner. Subjects with a positive screening challenge were rechallenged (at least 2 wk later) with a double-blind, placebo-controlled protocol as in-patients in our General Clinical Research Center. Two subjects had positive single-blind, placebo-controlled challenges, but neither had a positive double-blind, placebo-controlled challenge. It is concluded, with 95% confidence, that MSG is an unusual (<3% at most) exacerbant of chronic idiopathic urticaria.|For more Human Toxicity Excerpts (Complete) data for MONOSODIUM GLUTAMATE (21 total), please visit the HSDB record page.

Accent

Annnual Consumption (U.S.): 31,000,000 lb (From the PAFA database, originating from a NAS survey of 1987 and assumes only 60% of poundage was reported). Individual Consumption: 26.2711 mg/kg/day|26% used in dry & wet soup products; 22% in convenience foods; 22% by institutions (hospitals, schools, restaurants, hotels, etc); 16% by formulators of flavorings for various end uses; 12% in direct consumer sales; 2% in animal feed to induce early weaning of baby pigs (1975)|Derivate: Processed Food, 30%; Soups, 25%; Institutional, 25%; Direct Consumer, 15%; Misc, 5% (1983)

Grades: Technical, 99%; new drugs (ND); "Food Chemicals Codex".

Soap, cleaning compound, and toilet preparation manufacturing|L-Glutamic acid, N-coco acyl derivs., disodium salts: ACTIVE|A unique characteristic of the product is its ability to incr salivation.|The flavor of /sulfur-containing cmpd/ ... is usually depressed by the presence of MSG.|In unsalted chicken bouillon the minimum perceptible taste is lowered to 0.015%, & in carbonated beverages, to only 0.002%.|Product analysis: calories: 2.88 per g; free moisture: not more than 0.1%; not more than 0.1% as sodium chloride.|For more General Manufacturing Information (Complete) data for MONOSODIUM GLUTAMATE (8 total), please visit the HSDB record page.

A FLUOROMETRIC METHOD WAS USED TO DETERMINE MONOSODIUM GLUTAMATE IN FOODS.|NIOSH Method: 173. Analyte: Sodium. Matrix: Air. Procedure: Atomic absorption spectrophotometry. This method has a detection limit of 0.0002 and sensitivity of 0.015 ug/mL. The working range for a precision better than 3% RSD/CV is 0.05-1.0 ug/mL. Interference: Spectral, ionization, chemical and physical interferences. /Sodium/|NIOSH Method: 7300. Analyte: Sodium. Matrix: Air. Procedure: Inductively coupled argon plasma, atomic emission spectroscopy. For sodium this method has an estimated detection limit of 10 ng/ml sample. The precision/RSD and the recovery are not determined. Applicability: The working range of this method is 0.005 to 2.0 mg/cu m for each element in a 500 liter air sample. Interferences: Spectral interferences. /Sodium/|Method 3111-Metals A. Direct Aspiration Atomic Absorption Spectrometry is used for the determination of sodium in water and wastewater. Using air/acetylene as the flame gas at a wavelength of 589.0 nm, the detection limit is 0.002 mg/L, with a sensitivity of 0.015 mg/L, at an optimum concentration range of 0.03-1 mg/L. /Sodium/|For more Analytic Laboratory Methods (Complete) data for MONOSODIUM GLUTAMATE (11 total), please visit the HSDB record page.

EPA Safer Chemical Functional Use Classes -> Surfactants|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Food additives|Cosmetics -> Hair conditioning; Surfactant

Food Additives -> FLAVOUR_ENHANCER;