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Chitosan

Chitosan structure

CAS No:
9012-76-4
Chemical Name:
Chitosan
Synonyms:
Chitosan;Deacetylchitin;Chitin,N-deacetyl-;Chitan,N-acetyl-;Kytex H;Flonac N;Kytex M;DAC 70;Chicol;Kimitsu Chitosan F 2;Kimitsu Chitosan F;Kimitsu Chitosan M;Kimitsu Chitosan H;Kimitsu Chitosan L;Chitopearl 3510;Sea Cure F;Sea Cure Plus;Chitopearl BC 3000;Chitopearl BCW 3000;Chitopearl BCW 2500;Chitopearl BCW 3500;Chitopearl BCW 3507;Flonac C;Poliglusam;CTA 4;Kitan;Sea Cure 143;Sea Cure 340;NC 50F2;Kimitsu Chitosan LLW;Seasanmer N 2000;KML-V 2;KML-V 54;KLM-V 2;KLM-V 54;Profloc 320;HC 1 (polysaccharide);SC (polysaccharide);SC;HC 1;MA 1;WOT Recovery Floc T;Hiset KW 5;TKS 210;SK 200;Daichitosan VL;SK 50;Chitosan EL;TKS 250N;Sea Cure 243;Sea Cure 343;Marinkaito F 05N;Marinkaito F 05S;KW 5;North Chitosan MC 1;OTS 2;FCM 117;Daichitosan W 10;CTA 1 Lactic Acid;Sea Cure 123;Hydagen HCMF;Kimitsu Chitosan F 2P;Kimitsu Chitosan LL;Chitosan LLWP;LLWP;Kimitsu Chitosan MP;Chitosan MP;Chitosan LL;Crystan LA-S;Chitosan H;Chitosan VL;Chitosan CLH;Chitosan FL;Sea Cure 440;Chitosan M;MK 4;MK 4 (polysaccharide);Biopolymer L 112;Chitosom;Kurita;Profloc P;Hydagen CMFP;Koyo Chitosan SK 30;DAC 50;Chitosan LL 80;Chitosan 500;Chitosan F;100D-VL;KW 5 (polysaccharide);Marine Dew PC 100;K 5;K 5 (chitosan);Koyo Chitosan DAC 50;Flonac LV;Chitofos;Daichitosan P-VL;PSH 80;SA 50;Hydagan DCMF;Koyo Chitosan FM 80;SA 50 (bactericide);BC 10;North Chitosan MA 1;BC 10 (polysaccharide);Chitosan PSH;Daichitosan DVL;57285-05-9;98241-50-0;191045-06-4;1118546-53-4;1268699-64-4;1403748-72-0;1548444-29-6;1869074-89-4;1884679-12-2;2027511-54-0;2129975-33-1;2138871-39-1;2197029-97-1;2387717-47-5;2417799-74-5
Categories:
Cosmetic Ingredient > Film Forming

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Description

Chitosan is a natural polycationic linear polysaccharide derived from chitin.

Solid

Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.

Chitosan Basic Attributes

Molecular Weight：

162.164

Exact Mass：

162.077

EC Number：

618-480-0

DSSTox ID：

DTXSID6030992

HScode：

2932999099

Characteristics

PSA：

95.94

XLogP3：

-1.7113

Appearance：

Light beige solid

Density：

1 g/cm³

Melting Point：

102.5 °C

Refractive Index：

1.7

Water Solubility：

dilute aqueous acid (pH <6.5): soluble

Storage Conditions：

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

R20/21/22; R36/37/38

safety instructions：

S24/25

RTECS Number：

FM6300000

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

Not Classified

Drug Information

MeSH：

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)|Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure. (See all compounds classified as Hemostatics.)|Substances used to lower plasma cholesterol levels. (See all compounds classified as Anticholesteremic Agents.)|Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function. (See all compounds classified as Biocompatible Materials.)

MeSH Entry Terms：

Chitosan

Chitosan Use and Manufacturing

Methods of Manufacturing

1. Alaska deep-sea snow crab by decalcification, deproteinization, decolorization, deacetylation and other processing from the body, the sixth element of life in the world's reputation.
2. With 4% ~ 6% aqueous solution of hydrochloric acid, at room temperature will be soaked 4 ~ 12h, picking chitin, and then add concentrated alkali, at 60 ~ 140 ℃, 8h reaction can be washed.
3. Shrimp or crab shell soaked in 6% hydrochloric acid, remove the inorganic salt in the shell, washed. And then with 10% sodium hydroxide solution to remove the protein, washed with water, then 1% KMnO4 bleach oxidation, in addition to impurities, and then washed; with 1% NaHSO4 elution of residual mNo4, and then fully washed, dried, you can get Pure chitosan.
4. Biological method Because of the high cost of producing chitosan by fermentation, it is difficult to implement large-scale industrial production. At present in the antibiotic industry in a large number of penicillin or citric acid mycelium as a waste, the analysis of mycelia containing a considerable amount of chitosan.

Uses

1. Forms gels with multivalent anions. Gives clear solutions that dry to strong, clear films.
2. Ideal for wound healing and hemostasis; biosurgery and ophthalmology; scaffold and cell therapy; and drug delivery and vaccines
3. Flocculant, protein precipitation, encapsulating agent and aqueous thickener.
4. Also available in pharma grade

Manufacturing Info：

Chitosan: ACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).

Use Classification：

EPA Safer Chemical Functional Use Classes -> Antimicrobial Actives;Preservatives and Antioxidants|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Cosmetics -> Film forming

Computed Properties

Molecular Weight:1526.5
XLogP3:-21.4
Hydrogen Bond Donor Count:29
Hydrogen Bond Acceptor Count:47
Rotatable Bond Count:27
Exact Mass:1525.6353145
Monoisotopic Mass:1525.6353145
Topological Polar Surface Area:808
Heavy Atom Count:104
Complexity:2630
Defined Atom Stereocenter Count:45
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Sodium hydroxide

Formaldehyde

Acrylamide

Polyacrylamide

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Xinxing Chitosan Capsules

Chitosan powder (original name: Chitosan powder)

Sixth Element Chitosan Capsules
Specifications	400 mg/capsule

See More Related Drugs

Registered Holders

Hunan New Green Formula Pharmaceutical Co., Ltd.

China
Active
Yantai Luyin Pharmaceutical Co., Ltd.

China
Active
ZHEJIANG GOLDEN-SHELL PHARMACEUTICAL CO LTD

United States
Active

See More Registered Holders

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