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Guanine

Guanine structure

CAS No:
73-40-5
Formula:
C5H5N5O
Chemical Name:
Guanine
Synonyms:
6H-Purin-6-one,2-amino-1,9-dihydro-;Guanine;6H-Purin-6-one,2-amino-1,7-dihydro-;2-Amino-1,9-dihydro-6H-purin-6-one;C.I. 75170;2-Aminohypoxanthine;C.I. Natural White 1;Hypoxanthine,2-amino-;Pearl Essence;Stella Polaris;2-Amino-6-hydroxypurine;2-Amino-6-hydroxy-1H-purine;Guanine enol;Dew Pearl;Naturon;Guanin;Mearlmaid;Natural Pearl Essence;Natural White 1;Mearlmaid AA;9H-Guanine;2-Amino-6,7-dihydro-1H-purin-6-one;2-Imino-2,3-dihydro-1H-purin-6-ol;2-Amino-6,7-dihydro-3H-purin-6-one;2-Amino-1H-purin-6(7H)-one;2-Amino-9H-purin-6-ol;2-Amino-3,7-dihydropurin-6-one;2-Amino-6,9-dihydro-3H-purin-6-one;2-Amino-1,9-dihydro-purin-6-one;2-Amino-6,9-dihydro-1H-purin-6-one;492-33-1;8039-79-0;11006-44-3;15986-36-4;37432-34-1;54435-87-9;69257-39-2;158475-99-1;66224-64-4;929247-29-0;934585-79-2;936902-27-1
Categories:
Cosmetic Ingredient > Cosmetic Colorant

Description

Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

Solid

Guanine is a 2-aminopurine carrying a 6-oxo substituent. It has a role as a human metabolite, an algal metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purine nucleobase, an oxopurine and a member of 2-aminopurines. It derives from a hydride of a 9H-purine.|Guanine is a purine base that is a constituent of nucleotides occurring in nucleic acids.

Guanine Basic Attributes

Molecular Weight：

151.13

Exact Mass：

151.13

BRN：

9680

EC Number：

200-799-8

UNII：

5Z93L87A1R

DSSTox ID：

DTXSID9052476

NCI Thesaurus Code：

C532

Color/Form：

SEVERAL DESMOTROPIC FORMS; USUALLY AMORPHOUS|SMALL RHOMBIC CRYSTALS BY SLOW EVAPORATION OF AQ SOLN CONTAINING LARGE EXCESS OF AMMONIA|NEEDLES OR PLATES FROM AMMONIUM HYDROXIDE

HScode：

29335990

Characteristics

PSA：

96.2

XLogP3：

-1

Appearance：

White to cream Powder

Density：

2.2±0.1 g/cm3

Melting Point：

360 °C (decomp)

Boiling Point：

591.4ºC at 760 mmHg

Flash Point：

293.4±27.9 °C

Refractive Index：

2.047

Water Solubility：

Practically insoluble in water;1 M NaOH: 0.1 M at 20 °C, clear, colorless

Storage Conditions：

2-8°C

Dissociation Constants：

B: 6.09X10-4; A: 1.19X10-10 @ 40 °C

Collision Cross Section：

133.55 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|124 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|129.9 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|136 Å² [M+K]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|137.8 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|131 Å² [M+H]+

Experimental Properties：

MANY COMPD WITH ACIDS, BASES & METALS HAVE BEEN PREPARED

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36-37/39

RTECS Number：

MF8260000

Marks：

Hazard note：

Irritant

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (99.11%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 113 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Natural Pollution Sources：

OCCURS IN ANIMAL & PLANT KINGDOM. FIRST ISOLATED FROM GUANO.|PURINE CONSTITUENT OF RIBONUCLEIC ACID & DEOXYRIBONUCLEIC ACID. USUAL SOURCES...SUGAR BEETS, YEAST, CLOVER SEED & FISH SCALES.

Drug Information

Absorption：

ORAL ADMINISTRATION OF GUANINE TO RATS RESULTED IN INCREASED URINARY EXCRETION OF THE NITROGEN COMPOUNDS, UREA AND AMMONIA.

MeSH Entry Terms：

Guanine

Guanine Use and Manufacturing

Methods of Manufacturing

FISHER, BER 30, 2226 (1897); TRAUBE, BER 33, 1371 (1900). GERMAN PATENTS 134,984 (1903), 158,591 (1903), 162,336 (1904). PREPARATION OF (15)N-ISOTOPIC GUANINE FOLLOWING TRAUBE'S SYNTHESIS: PLENTL, SCHOENHEIMER, J BIOL CHEM 153, 203 (1944).

Uses

Guanine is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA.

Formulations：

AVAILABLE AS HYDROCHLORIDE OR HEMISULFATE

Manufacturing Info：

6H-Purin-6-one, 2-amino-1,9-dihydro-: ACTIVE|GUANINE IS PERMANENTLY LISTED UNDER THE FEDERAL FOOD, DRUG AND COSMETIC ACT AS A COLOR ADDITIVE FOR USE IN EXTERNALLY APPLIED DRUGS AND COSMETICS, INCLUDING THOSE INTENDED FOR USE IN THE AREA OF THE EYE.

Analytic Methods：

ENZYMATIC ASSAY USING SPECTROPHOTOMETRY.

Use Classification：

Cosmetics -> Cosmetic colorant; Opacifying

Computed Properties

Molecular Weight:151.13
XLogP3:-1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Exact Mass:151.04940980
Monoisotopic Mass:151.04940980
Topological Polar Surface Area:96.2
Heavy Atom Count:11
Complexity:225
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Guanine

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Guanine

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