Tetramethoxysilane

152.22100

152.22

211-656-4

19D35VPL66

1188

67383

2606

DTXSID3027291

Colorless liquid|Clear, colorless liquid [Note: A solid below 28 degrees F].

29209085

36.92000

0.00760

colourless liquid

1.032 g/cm³ @ Temp: 20 °C

-2 °C

121-122 °C @ Press: 760 Torr

26ºC

1.367-1.37

hydrolysis

Flammables area

3.35 psi ( 20 °C)

5.25 (vs air)

Class IIIB Combustible Liquid: Fl.P. at or above 200°F.

During the preparation of the hexamethoxides of rhenium, molybdenum and tungstenby co-condensation with excess /tetramethyl silicate/ on a cold surface, simultaneous co-condensation is necessary to avoid the danger of explosion present when sequential condensation of the reactants is employed. In the latter case, the high concentrations of hexafluoride at the interface leads to violent reaction with silane.

Henry's Law constant = 6.4X10-6 atm-cu m/mol at 25 °C (est)

Hydrolyzes in water after 2 days|Hydroxyl radical reaction rate constant = 3.3X10-12 cu cm/molecule-sec at 25 °C (est)

Flammable. Insoluble in water.

Siloxanes

Highly Flammable

METHYL ORTHOSILICATE is incompatible with the following: Oxidizers; hexafluorides of rhenium, molybdenum & tungsten (NIOSH, 2016).

Class IIIB Combustible Liquid: Fl.P. at or above 200°F.

46.5 kJ/mol

I

6.1

UN 2606 6.1/PG 1

3

R10; R26; R37/38; R41

S16-S26-S28-S36/37/39-S45

VV9800000

T+

Fireproof. Separated from food and feedstuffs.

VOLATILE

P210-P260-P280-P304 + P340 + P310-P305 + P351 + P338 + P310-P370 + P378

H226-H315-H318-H330

Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. Contact a licensed professional waste disposal service to dispose of this material.|SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Materials to avoid: Oxidizing agents, acids, bases.|Oxidizers; hexafluorides of rhenium, molybdenum & tungsten.

Excerpt from ERG Guide 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. (ERG, 2016)|Flammable. Above 20 °C explosive vapour/air mixtures may be formed.|Flammable - 3rd degree, Reactive - 1st degree

|Danger|H226 (91.9%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P284, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P310, P312, P314, P320, P321, P330, P332+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 268 companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P264, P270, P271, P280, P284, P303+P361+P353, P304+P340, P305+P351+P338, P309+P311, P310, P314, P320, P370+P378, P403+P233, P403+P235, P405, and P501|P210, P233, P240, P241, P242, P243, P260, P264, P270, P271, P280, P284, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P309+P311, P310, P314, P320, P321, P332+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 2606 datasheet. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. A vapor-suppressing foam may be used to reduce vapors. FOR CHLOROSILANES, use AFFF alcohol-resistant medium-expansion foam to reduce vapors. DO NOT GET WATER on spilled substance or inside containers. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas. SMALL SPILL: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should wash daily at the end of each work shift. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. (NIOSH, 2016)|Wear protective gloves and clothing to prevent any reasonable probability of skin contact ... Contact lenses should not be worn when working with this chemical. Wear splash-proof chemical goggles and face shield unless full facepiece respiratory protection is worn. Employees should wash immediately with soap when skin is wet or contaminated. Provide emergency showers and eyewash.|... Wear positive pressure self-contained breathing apparatus ... If contact with the material anticipated, wear appropriate chemical protective clothing. /Methyl orthosilicate/|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|For more Personal Protective Equipment (PPE) (Complete) data for Tetramethyl silicate (9 total), please visit the HSDB record page.|(See protection codes)

Corrosive and flammable liquid.

Above 20 °C explosive vapor/air mixtures may be formed.|During the preparation of the hexamethoxides of rhenium, molybdenum and tungstenby co-condensation with excess /tetramethyl silicate/ on a cold surface, simultaneous co-condensation is necessary to avoid the danger of explosion present when sequential condensation of the reactants is employed. In the latter case, the high concentrations of hexafluoride at the interface leads to violent reaction with silane.

This chemical is a combustible liquid. Poisonous gases including silicon oxide are produced in fire. Use dry chemical, carbon dioxide, alcohol or polymer foam extinguishers. Do not use water. Vapors are heavier than air and will collect in low areas. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of contaners may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. Containers may explode in fire. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position ...|If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources ... If fire becomes uncontrollable or container is exposed to direct flame, consider evacuation of one-third (1/3) mile. /Methyl orthosilicate/|Suitable extinguishing media: For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. ... Use water spray to cool unopend containers.|Special protective equipment for fire-fighters: Wear self contained breathing apparatus for fire fighting if necessary.

Vapors are heavier than air and may travel to a source of ignition and flash back. Combustion may produce irritants and toxic gases.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.|Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Ventilate area of spill or leak. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the buildup of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters ...|Initial isolation and protective action distances: Small spills (from a small package or a small leak from a large package): first isolate in all directions 200 feet. Then protect persons downwind 0.1 mile (day), 0.3 mile (night). Large spills (from a large package or from many small packages): first isolate in all directions 500 feet. Then protect persons downwind 0.3 mile (day), 1.0 mile (night). Distances shown are likely to be affected during the first 30 minutes after materials are spilled and could increase with time. If more than one tank car, cargo tank, portable tank, or large cylinder is involved in the incident is leaking, the protective action distance may need to be increased ...|Land spill: Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.|For more Cleanup Methods (Complete) data for Tetramethyl silicate (8 total), please visit the HSDB record page.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors ... If material leaking (not on fire), consider evacuation from downwind area based on amount of material spilled, location, and weather condition. /Methyl orthosilicate/|Avoid breathing vapors. Keep upwind ... Do not handle broken packages unless wearing appropriate personal protective equipment. If contact with the material anticipated, wear appropriate chemical protective clothing. /Methyl orthosilicate/|Since contact with vapor or liq produces no immediate warning pain, special precautions are required with this substance. Breakage of flasks must be avoided. Eyes must be protected by gas tight goggles and risk of inhalation of vapors in case of spillage ... must be avoided by ... exhaust ventilation system.|SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|For more Preventive Measures (Complete) data for Tetramethyl silicate (10 total), please visit the HSDB record page.

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY. /Methyl orthosilicate/|/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.|/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ Health: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns, or death. ... Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat which will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.|/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.|For more DOT Emergency Guidelines (Complete) data for Tetramethyl silicate (9 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Methyl silicate can affect you when breathed in. Severely irritates and burns the eyes and skin. Exposure to the vapor can cause severe eye damage and cause permanent blindness. This can occur up to 12 hours after exposure has ceased, even if no irritation is noticed at the time. Inhalation irritates the respiratory tract. Higher exposures can cause pulmonary edema, a medical emergency, that can be delayed for several hours. This can cause death. Exposure to high levels can damage the lungs and kidneys.|A severe eye irritant. This material can cause extensive necrosis (experimentally), keratoconus, and opaque cornea. It also causes severe human eye injuries, as well as necrosis of corneal cells, which progresses long after exposure has ceased. It is destructive and its effects resist treatment. Permanent blindness is possible from exposure to it.|May be fatal if inhaled. Causes respiratory tract irritation. May be harmful if absorbed through skin. Causes skin irritation. Causes serious eye irritation.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 ppm (6 mg/cu m).

Collect leaking and spilled liquid in sealable containers as far as possible. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: chemical protection suit including self-contained breathing apparatus.

Fireproof. Separated from food and feedstuffs.

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is severely irritating to the eyes, skin and respiratory tract. Inhalation of the vapour may cause lung oedema. The effects may be delayed. Medical observation is indicated.

The substance may have effects on the kidneys and liver.

NO open flames, NO sparks and NO smoking. Above 20 °C use a closed system, ventilation and explosion-proof electrical equipment.

PREVENT GENERATION OF MISTS! STRICT HYGIENE!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles or eye protection in combination with breathing protection.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 1 - Materials that in themselves are normally stable but that can become unstable at elevated temperatures and pressures.

LC50 Guinea pig inhalation 300 ppm/1 hr|LC50 Guinea pig inhalation 95 ppm/4 hr|LC50 Guinea pig inhalation 26 ppm/8 hr|LD50 Mouse ip 250 mg/kg|LD50 Rabbit skin 17g/kg

Tetramethyl silicate's production and use as a chemical in the glass frosting process for televisions(1) or starting material in synthesizing sol-gels(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 650(SRC), determined from a structure estimation method(2), indicates that tetramethyl silicate is expected to have low mobility in soil(SRC). Volatilization of tetramethyl silicate from moist soil surfaces may be an important fate process(SRC) given an estimated Henry's Law constant of 6.4X10-6 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Tetramethyl silicate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 16.5 mm Hg at 20 °C(4). Biodegradation data were not available(SRC, 2009).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 650(SRC), determined from a structure estimation method(2), indicates that tetramethyl silicate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces may occur(3) based upon an estimated Henry's Law constant of 6.4X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 7.3 and 57 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of -1.93(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data were not available(SRC, 2009).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tetramethyl silicate, which has a vapor pressure of 16.5 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tetramethyl silicate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4.8 days(SRC), calculated from its rate constant of 3.3X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Tetramethyl silicate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of tetramethyl silicate with photochemically-produced hydroxyl radicals has been estimated as 3.3X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 4.8 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Tetramethyl silicate is expected to undergo hydrolysis in the environment after 2 days(2). Tetramethyl silicate does not contain chromophores that absorb at wavelengths >290 nm(3) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated for tetramethyl silicate(SRC), using an estimated log Kow of -1.93(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of tetramethyl silicate can be estimated to be 650(SRC). According to a classification scheme(2), this estimated Koc value suggests that tetramethyl silicate is expected to have low mobility in soil.

The Henry's Law constant for tetramethyl silicate is estimated as 6.4X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that tetramethyl silicate may volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 7.3 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 57 days(SRC) Tetramethyl silicate's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Tetramethyl silicate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 16.5 mm Hg(3).

Occupational exposure to tetramethyl silicate may occur through inhalation(1) and dermal contact with this compound at workplaces where it is produced or used. It is unlikely that the general population would be exposed to tetramethyl silicate as it is primarily used in a manufacturing or research setting(SRC).|In coating picture screens of television picture tubes ... it presents both an inhalation and eye exposure hazard.

Excerpt from ERG Guide 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, wash the contaminated skin with soap and water. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Half-upright position. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Silane, Chlorosilane, and Related Compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal (refer to ingestion protocol in Section Three ... . Cover skin burns with sterile dressings after decontamination ... . /Silane, Chlorosilane, and Related Compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation at the first sign of upper airway obstruction may be necessary. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Silane, Chlorosilane, and related compounds/

/HUMAN EXPOSURE STUDIES/ Efforts to estimate the air concn ... relative to corneal damage in man revealed that in general, 200-300 ppm are required for 15 min to produce minimal lesions, 1000 ppm to produce injury requiring hospitalization.|/SIGNS AND SYMPTOMS/ A severe eye irritant. This material can cause extensive necrosis (experimentally), keratoconus, and opaque cornea. It also causes severe human eye injuries, as well as necrosis of corneal cells, which progresses long after exposure has ceased. It is destructive and its effects resist treatment. Permanent blindness is possible from exposure to it.|/SIGNS AND SYMPTOMS/ Methyl silicate can affect you when breathed in. Severely irritates and burns the eyes and skin. Exposure to the vapor can cause severe eye damage and cause permanent blindness. This can occur up to 12 hours after exposure has ceased, even if no irritation is noticed at the time. Inhalation irritates the respiratory tract. Higher exposures can cause pulmonary edema, a medical emergency, that can be delayed for several hours. This can cause death. Exposure to high levels can damage the lungs and kidneys.|/SIGNS AND SYMPTOMS/ The substance irritates severely the eyes, the skin and the respiratory tract. Inhalation of vapor may cause lung edema ... The symptoms of lung edema often do not become manifest until a few hours have passed, and they are aggravated by physical effort ... The substance may have effects on the kidneys and liver..|For more Human Toxicity Excerpts (Complete) data for Tetramethyl silicate (6 total), please visit the HSDB record page.

silicic acid tetramethyl ester

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.|inhalation, ingestion, skin and/or eye contact

irritation eyes, corneal damage (following even short-term exposure to the vapor); lung, kidney injury; pulmonary edema

Burning sensation. Cough. Shortness of breath. Sore throat. Symptoms may be delayed.

Redness. Pain.

Redness. Pain. Loss of vision.

Eyes, respiratory system, kidneys

Silicic acid (H4SiO4), tetramethyl ester: ACTIVE|Silica aerogels are usually prepared by base-catalyzed reaction of tetramethoxysilane (TMOS) or tetraethoxysilane(TEOS), mostly with ammonia as the catalyst. A modification of this procedure is to pre-hydrolyze Si(OR)4 with a small amount of water under acidic conditions.

Fire Hazards -> Flammable - 3rd degree, Reactive - 1st degree