Trimethyl borate

103.91

103.91

1697939

204-468-9

82U64J6F5N

0593

777

2416

DTXSID0037738

Colorless, moisture-sensitive liquid; fumes in air

29209085

27.7

-1.9

Colorless Liquid

0.915 g/cm³

-29.3 °C

67-68 °C

8 °F

n 20/D 1.358(lit.)

Solubility in water: reaction.;Miscible with tetrahydrofuran, ether, isoporpylamine, hexane and methanol.

Flammables area

Vapour pressure, kPa at 25°C: 18

3.59 (vs air)

Oral-Rat LD50: 13000 mg/kg; Oral-Mouse LD50: 1290 mg/kg

Inflammable in case of fire, high temperature and oxidant; produces toxic flammable boride gas in contact with water

Reacts with oxidants causing fire and explosion hazard. /table/

Stable in the absence of moisture; hydrolyzes in the presence of water to methanol and boric acid. ... Forms azeotrope with methanol: 70% trimethyl borate and 30% methanol|Decomposes in water.|Dissolves in water with hydrolysis to form boric acid and the corresponding alcohol or phenol /Boric acid esters/

Highly flammable. Rapidly decomposes in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Highly Flammable

Borates, such as TRIMETHYL BORATE, behave similarly to esters in that they react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters/borates with alkali metals and hydrides.

The vapour is heavier than air and may travel along the ground; distant ignition possible.

II

3

UN 2416 3/PG 2

3

11-21-23/25-36/37/38-10-36-61-60

16-27-36/37/39-45-25-23-2-26-53

ED5600000

Xn,F,T

Treasury is ventilated, low temperature and dry; stored separately from oxidant

Stable. Incompatible with oxidizing agents. Decomposes slowly in the presence of moisture, rapidly in water. Flammable.

P210, P233, P240, P241, P242, P243, P280, P302+P352, P303+P361+P353, P312, P322, P363, P370+P378, P403+P235, P501

H226

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

... Reacts with water and oxidizing agents.|Hydrolyzes in presence of water to methanol and boric acid.|Will react with water or steam to produce toxic and flammable vapors.

USEPA/OWRS; Quality Criteria for Water 1986 Boron (1986) EPA 440/5-86-001

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)|Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive.|Flammable - 3rd degree, Reactive - 1st degree

|Warning|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P280, P302+P352, P303+P361+P353, P312, P322, P363, P370+P378, P403+P235, and P501|Danger|H225 (40.06%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P201, P202, P210, P233, P240, P241, P242, P243, P264, P280, P281, P302+P352, P303+P361+P353, P305+P351+P338, P308+P313, P312, P322, P337+P313, P363, P370+P378, P403+P235, P405, and P501|Aggregated GHS information provided by 342 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P201, P202, P210, P233, P240, P241, P242, P243, P260, P264, P270, P280, P281, P301+P312, P303+P361+P353, P305+P351+P338, P307+P311, P308+P313, P321, P330, P337+P313, P370+P378, P403+P235, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P322, P337+P313, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. (ERG, 2016)|Protective gloves and safety spectacles /should be worn for/ prevention.

Flammable, fire risk ...|A very dangerous fire hazard when exposed to heat, flame, or oxidizers.

Reacts with oxidants causing fire and explosion hazard. /table/

To fight fire use dry chemical, CO2, spray, foam.|If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid stream of water may be ineffective. Cool all affected containers with flooding quantities of water. Use "alcohol" foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources.

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place. Do NOT wash away into sewer (extra personal protection: self-contained breathing apparatus). /table/

Do not breathe gas, fumes, vapor, or spray. Avoid contact with eyes.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|For more Preventive Measures (Complete) data for TRIMETHYL BORATE (6 total), please visit the HSDB record page.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for TRIMETHYL BORATE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

The substance irritates the eyes, the skin and the respiratory tract.|... May produce irritation of the nasal mucous membranes, the respiratory tract, and eyes. /Boron compounds/

Personal protection: filter respirator for organic vapours of low boiling point adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Do NOT wash away into sewer. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.

Fireproof. Separated from strong oxidants and strong acids. Dry.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is irritating to the eyes. The substance may cause effects on the central nervous system and kidneys. This may result in headache, dizziness and impaired functions.

The substance may have effects on the central nervous system and kidneys. Further see ICSC 0057 and ICSC 0991.

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.

Use ventilation.

Protective gloves.

Wear safety goggles.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 1 - Materials that in themselves are normally stable but that can become unstable at elevated temperatures and pressures.

moderately toxic

LD50 Rat oral 6140 mg/kg|LD50 Mouse oral 1290 mg/kg|LD50 Rabbit dermal 1980 mg/kg

Borates are found in ocean water, sedimentary rocks, coal, shale, and soils(1).

Trimethyl borate's production and use as a solvent, flame retardant for textiles, dehydrating agent, brazing flux, wood preservative, catalyst, as well as it use as an intermediate for the synthesis of boron compounds and in scintillation counters(1-3) may result in its release to the environment through various waste streams(SRC). Trimethyl borate is used to treat wood where it is decomposed to boric acid upon contact with the moisture in the wood; the boric acid formed acts as a wood preservative preventing damage from wood-destroying fungi and insects(2).

TERRESTRIAL FATE: Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(1,2). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC).|AQUATIC FATE: Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(1,2). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethyl borate, which has a vapor pressure of 136 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(3,4). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC).

Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(1,2). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC).

Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(1,2). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC). Bioconcentration is not considered an important environmental fate for trimethyl borate(SRC).

Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(1,2). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC). Adsorption to soil or suspended particles in water is not considered an important environmental fate for trimethyl borate(SRC).

Trimethyl borate is rapidly hydrolyzed to boric acid and methanol in the presence of water(1,2). Hydrolysis would be expected to be the dominate fate process for trimethyl borate in the environment(SRC). Volatilization from water or soil is not considered an important environmental fate for trimethyl borate(SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 4,878 workers (369 of these are female) are potentially exposed to trimethyl borate in the US(1). Occupational exposure to trimethyl borate may occur through inhalation and dermal contact with this compound at workplaces where trimethyl borate is produced or used(SRC). Exposure to the general population should not occur, due to the rapid decomposition of trimethyl borate upon contact with water(SRC).

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Keep victim calm and warm. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. (ERG, 2016)

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Maintain an open airway and assist ventilation if nescessary. treat coma, seizures, hypotension, and renal failure if they occur. There is no specific antidote. Administer activated charcoal (although boric acid is not well absorbed). Consider gastric lavage for large ingestions. /Boric acid, Borates, and Boron/|Hemodialysis is effective and is indicated after massive ingestions and for supportive care of renal failure. Peritoneal dialysishas not proved effective in enhancing elimination in infants. /Boric acid, Borates, and Boron/|In acute poisonings, if a large amount has been ingested and the patient is seen within one hour of exposure, gastrointestinal decontamination should be considered ... .It is important to keep in mind that vomiting and diarrhea are common, and severe poisoning may be associated with seizures. Therefore induction of emesis by syrup of ipecac is probably contraindicated in these exposures. Catharsis is not indicated if diarrhea is present. /Boric acid and Borates/|If ingestion of borate has been massive (several grams), or has extended over several days, administer intravenous glucose and electrolyte solutions to sustain urinary excretion of borate. Monitor fluid balance and serum electrolytes (including bicarbonate capacity ) regularly. Monitor cardiac status by ECG. Test the urine for proteins and cells to detect renal injury, and monitor serum concentration of borate. Metabolic acidosis may be treated with sodium bicarbonate. If shock develops, it may be necessary to infuse plasma or whole blood. Administer oxygen continuously. If oliguria (less than 25 to 30 mL urine per hour) occurs, intravenous fluids must be slowed or stopped to avoid overloading the circulation. Such patients should be referred to a center capable of providing intensive care for critically ill patients. /Boric acid and Borates/|For more Antidote and Emergency Treatment (Complete) data for TRIMETHYL BORATE (7 total), please visit the HSDB record page.

/SIGNS AND SYMPTOMS/ Inhalation: Cough, sore throat. Eyes: Redness, pain. Skin: Redness, burning sensation. /table/|/OTHER TOXICITY INFORMATION/ Harmful in contact with skin

trimethyl borate

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Cough. Sore throat.

Redness. Burning sensation.

Redness. Pain.

All other basic inorganic chemical manufacturing|Boric acid (H3BO3), trimethyl ester: ACTIVE|US 2689259; US 2884439; US 2937195 (to Callery Chem)|US 2881227 and US 2884440 (to Olin Mathieson)|US 2855427 (to Am. Potash & Chem.)|US 2739979 ( to USAEC)

Fire Hazards -> Flammable - 3rd degree, Reactive - 1st degree