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Apixaban

Apixaban structure
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Description

Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.

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Basic Attributes

  • 503612-47-3

  • C25H25N5O4

  • 459.504

  • 459.190643

  • 111

  • 2.2

  • QNZCBYKSOIHPEH-UHFFFAOYSA-N

  • 5

  • 1

  • 0.28

  • 5

Characteristics

  • 1.42

  • 770.468ºC at 760 mmHg

  • 419.8±32.9 °C

  • 1.705

  • Aqueous solubility: 40-50 μg/ml in 0.9% saline solutionAqueous solubility across the physiological pH range is approximately 0.04 mg/L

  • Store at 20 deg C to 25 deg C (68 deg F-77 deg F); excursions permitted between 15 deg C and 30 deg C (59 deg F-86 deg F).

  • 4.29X10-18 mm Hg at 25 deg C (est)

Safety Information

  • P260, P264, P270, P314, P501

  • H372

Usage

Apixaban, sold under the tradename Eliquis, is an anticoagulant for the treatment of venous thromboembolic events. It is taken by mouth. It is a direct factor Xa inhibitor.Apixaban was approved in Europe in 2012. It was approved in the U.S. in 2014 for treatment and secondary prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism (PE). It is being developed in a joint venture by Pfizer and Bristol-Myers Squibb.

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Price Analysis

  • 2022-03-18

    USD offers of Apixaban is 3091USD/KG FCA Shanghai.

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