Apixaban
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Apixaban
structure -
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CAS No:
503612-47-3
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Formula:
C25H25N5O4
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Chemical Name:
Apixaban
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Synonyms:
1H-Pyrazolo[3,4-c]pyridine-3-carboxamide,4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-;4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide;BMS 562247-01;Apixaban;Eliquis;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide
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CAS No:
Description
Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.
Characteristics
111
2.2
1.42
770.468ºC at 760 mmHg
419.8±32.9 °C
1.705
Aqueous solubility: 40-50 μg/ml in 0.9% saline solutionAqueous solubility across the physiological pH range is approximately 0.04 mg/L
Store at 20 deg C to 25 deg C (68 deg F-77 deg F); excursions permitted between 15 deg C and 30 deg C (59 deg F-86 deg F).
4.29X10-18 mm Hg at 25 deg C (est)
Apixaban Use and Manufacturing
Apixaban, sold under the tradename Eliquis, is an anticoagulant for the treatment of venous thromboembolic events. It is taken by mouth. It is a direct factor Xa inhibitor.Apixaban was approved in Europe in 2012. It was approved in the U.S. in 2014 for treatment and secondary prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism (PE). It is being developed in a joint venture by Pfizer and Bristol-Myers Squibb.
Drug Function and Efficacy
It is an oral selective activated factor X inhibitor that can prevent thrombosis, but the adverse reaction of bleeding is lower than that of the old drug warfarin. It is used to prevent thrombosis in patients who have undergone hip or knee replacement surgery.
Registered Holders
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METROCHEM API PRIVATE LTD
Active
United States
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SRINI PHARMACEUTICALS PRIVATE LTD
Active
United States
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MICRO LABS LTD
Active
United States
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