(Chloromethoxy)ethane

94.54

94.54

221-687-5

08T7N64Z04

2354

DTXSID7062902

2909199090

9.2

0.68

Clear colorless to pale yellow Liquid

1.0188 g/cm³ @ Temp: 15 °C

-98ºC

83 °C

67 °F

1.387

0-6°C

Flammable; toxic chloride fumes are emitted from the fire

Explosion hazard when exposed to heat or flame.

Highly flammable. Insoluble in water.

Ethers

Highly Flammable

CHLOROMETHYL ETHYL ETHER tends to form unstable peroxides when exposed to oxygen or air. These products can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Forms salts with strong acids and addition complexes with Lewis acids. May react violently with strong oxidizing agents.

I

6.1(a)

UN 2354 3/PG 2

3

11-20/21/22-36-40

16-36/37-9-45-29

F,Xn

Warehouse low temperature, ventilated, dry; fire prevention; anti-vibration

Fire and explosion

P210-P280-P305 + P351 + P338

H225-H302 + H312 + H332-H319-H351

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|This compound should be susceptible to removal from waste water by air stripping. /Bis(2-chloroethyl)ether/

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)|Flammable - 3rd degree, Reactive - 1st degree

|Danger|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P322, P330, P337+P313, P363, P370+P378, P403+P235, P405, and P501|Aggregated GHS information provided by 43 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: CAUTION: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient. SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. LARGE FIRE: Water spray, fog or alcohol-resistant foam. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. Use water spray or fog; do not use straight streams. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2016)

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: Fully encapsulating, vapor-protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. SMALL SPILL: Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. (ERG, 2016)

A very dangerous fire and explosion hazard when exposed to heat or flame.

... explosion hazard when exposed to heat or flame.

/GUIDE 131: FLAMMABLE LIQUIDS - TOXIC/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 131: FLAMMABLE LIQUIDS - TOXIC/ Health: TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 131: FLAMMABLE LIQUIDS - TOXIC/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 131: FLAMMABLE LIQUIDS - TOXIC/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.|For more DOT Emergency Guidelines (Complete) data for CHLOROMETHYL ETHYL ETHER (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

There are no known natural sources of chloromethyl ethyl ether(1).

Chloromethyl ethyl ether has been listed as a compound with no specific industrial manufacture or use(1). The compound has been listed as a possible byproduct of water chlorination; a probable precursor is methyl ethyl ether(1).

TERRESTRIAL FATE: The fate of chloromethyl ethyl ether in soil is unknown. However, due to its expected rapid hydrolysis rate in water, which is based upon measured hydrolysis rates for the structurally related chloromethyl methyl ether(1), chloromethyl ethyl ether would be expected to disappear rapidly from moist soil. Significant adsorption to soil, therefore, is not expected to occur.|AQUATIC FATE: If released to water, chloromethyl ethyl ether will hydrolyze rapidly based upon the hydrolysis half-life of <1 sec for the structurally related chloromethyl methyl ether in pure water at 20 °C(1). It will not, therefore, be expected to adsorb to sediment or suspended particulates, bioconcentrate in aquatic organisms, biodegrade, or significantly volatilize from water(SRC).|ATMOSPHERIC FATE: If released to the atmosphere, chloromethyl ethyl ether will be subject reaction with photochemically produced hydroxyl radicals with a half-life of 53 hours estimated for this process(1,SRC). It may be susceptible to surface catalyzed(2) hydrolysis in humid air, based upon observed hydrolysis of the structurally related chloromethyl methyl ether in humid air(3).

Hydrolysis of chloromethyl ethyl ether is expected to be very rapid(SRC), based upon the hydrolysis half-life of <1 sec for the structurally related chloromethyl methyl ether in pure water at 20 °C(1). It may be susceptible to surface catalyzed(2) hydrolysis in humid air, based upon observed hydrolysis of the structurally related chloromethyl methyl ether in humid air(1). The rate constant for the vapor phase reaction of chloromethyl ethyl ether with photochemically produced hydroxyl radicals has been estimated to be 7.2X10-12 cu cm/molecule-sec at 25 °C which corresponds to an atmospheric half-life of 53 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(3,SRC).

Based upon the hydrolysis half-life of <1 sec for the structurally related chloromethyl methyl ether in pure water at 20 °C(1), bioconcentration of chloromethyl ethyl ether in the food chain is unlikely to occur(SRC).

Based upon the hydrolysis half-life of 18 sec for the structurally related chloromethyl methyl ether in pure water at 20 °C(1), significant volatilization from water is unlikely to occur(SRC). Based upon an estimated vapor pressure of 59 mm Hg(2), evaporation from surfaces and dry near-surface soil may be an important process(SRC).

DRINKING WATER: Chloromethyl ethyl ether has been listed in a literature review as a compound which has been found, but not quantified, in drinking water from unidentified sources(1), in the US(2) and in New Orleans(3); no dates were reported. Detection of considerable amounts of the compound in water is unlikely based upon the expected rapid hydrolysis in water based upon the hydrolysis half-life of 18 sec for the structurally related chloromethyl methyl ether in pure water at 20 °C(4).

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Keep victim calm and warm. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. (ERG, 2016)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Treat frostbite by rapid rewarming ... . /Ethers and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: To keep open, "minimal flow rate"/. Use lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ethers and related compounds/

... /CNS effect/ causes loss of consciousness on appreciable exposure and, as good fat solvents, they cause dermatitis on repeated or prolonged skin contact. ... Enclosure and ventilation are to be employed /Chloromethyl ethers/

chloromethyl ethyl ether

Ethane, (chloromethoxy)-: ACTIVE|The compound has been listed as a possible byproduct of water chlorination; a probable precursor is methyl ethyl ether.

ON-COLUMN REACTION GAS CHROMATOGRAPHY FOR DETERMINATION OF CHLOROMETHYL METHYL ETHER @ 1 PART/BILLION LEVEL IN AMBIENT AIR. /CHLOROMETHYL METHYL ETHER/|CHLOROMETHYL METHYL ETHER ANALYSIS BY ELECTRON-CAPTURE GAS CHROMATOGRAPHY. SENSITIVITY: 0.5 PPB FOR 10 L SAMPLE. /CHLOROMETHYL METHYL ETHER/|A method was developed for the trace level determination of chloromethyl methyl ether in air. The method consists of a preconcentration step on a Tenax adsorption tube followed by solvent desorption and derivatization with sodium pentafluorophenolate. The derivatives are analyzed by capillary gas chromatography with electron capture detection. Formation of the derivatives was demonstrated by comparison with a synthetic standard using mass spectrometry. The achievable detection limit was 15 parts per trillion (vol/vol) for a 30 liter sample. /Chloromethyl methyl ether/|Monitoring method: Analyte: Chloromethyl methyl ether. Matrix: Air. Procedure: Gas Chromatography-Electron Capture Detector. 1.83 m x 6.35 mm glass column. Flow rate is 30 cu cm/minute. The column oven is operated isothermally at 140 °C. /Chloromethyl methyl ether/

Fire Hazards -> Flammable - 3rd degree, Reactive - 1st degree