 Home > Encyclopedia > Trelagliptin

Trelagliptin

Trelagliptin structure

CAS No:
865759-25-7
Formula:
C18H20FN5O2
Chemical Name:
Trelagliptin
Synonyms:
Benzonitrile,2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro-;2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile;Trelagliptin;(R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile;(R)-2-[[6-(3-AMinopiperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl]Methyl]-4-fluorobenzonitrile;2-[[6-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile
Categories:
Biochemical Engineering > Inhibitors

Description

Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). IC50 value:Target: DPP4Two Phase II clinical studies have been completed with Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus. Phase III clinical studies with trelagliptin in Japan to evaluate its safety and efficacy in a once-weekly oral treatment regimen. Currently, all available DPP-4 inhibitors are dosed once-dail

Trelagliptin is a member of benzenes and a nitrile.|Trelagliptin is under investigation in clinical trial NCT03555591 (Specified Drug-Use Survey of Trelagliptin Tablets "Survey on Long-term Use in Patients With Type 2 Diabetes Mellitus").

Trelagliptin Basic Attributes

Molecular Weight：

357.3821032

Exact Mass：

357.38

UNII：

Q836OWG55H

DSSTox ID：

DTXSID00235678

Characteristics

PSA：

93.7

XLogP3：

1.88

Appearance：

White to off-white solid

Density：

1.4±0.1 g/cm3

Boiling Point：

519.0±60.0 °C at 760 mmHg

Flash Point：

267.7±32.9 °C

Refractive Index：

1.646

Drug Information

MeSH Entry Terms：

SYR-472

Computed Properties

Molecular Weight:357.4
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:357.16010306
Monoisotopic Mass:357.16010306
Topological Polar Surface Area:93.7
Heavy Atom Count:26
Complexity:657
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Trelagliptin

HNB Biotech Contact Supplier

CN
1 YR

Business licensed Certified factory

Manufactory Supplier of Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive,Herb extract,Antibiotics,API,Virginiamycin,Copper Peptide,Potassium iodide,Minoxidil,Praziquantel,Fipronil,Topiramate,Bromhexine,Furazolidone,Nitrofurazone,Clotrimazole,Mebendazole,Fenbendazole,Amprolium,Enramycin,Sulfamethoxazole

Trelagliptin High purity of the CAS : 865759-25-7 Trelagliptin 99% Powder with best price

CAS No.: 865759-25-7

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Hangzhou Zentra Bio-Chemical Co., Ltd. Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of pharmaceutical intermediates,excipients,plant extracts,food additives,CDMO,fine cheimcals,Octadecanedioic acid,Eicosanedioic Acid

(R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile 865759-25-7

CAS No.: 865759-25-7

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Beton Nutrition Corporation Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of olive leaf extract,ginger extract,ginseng extract,Black garlic extract,Echinacea purpurea extract,Horse Chestnut Extract,Pueraria extract,Andrographis Extract,citrus aurantium extract,quercetin,Rutin,chlorogenic acid,Curcumin,Apigenin

High purity of the CAS :865759-25-7 Trelagliptin with best quality

CAS No.: 865759-25-7

Grade: Chemical Grade

Content: 99.9%

Inquiry
Emeishan Hongsheng Pharmaceutical Co.,Ltd Contact Supplier

CN
10 YRS

Business licensed Certified factory

Manufactory Supplier of APIS

Trelagliptin 99%

CAS No.: 865759-25-7

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Creative Enzymes Contact Supplier

US
6 YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

Trelagliptin

CAS No.: 865759-25-7

Content: 0.999%

Inquiry