Polymeric MDI

149.14668

250.074234

618-498-9

DARK-AMBER VISCOUS LIQUID

3909301000

58.86000

4.93

Polymeric diphenylmethane diisocyanate is a dark-brown liquid with a weak odor. Sinks in water. (USCG, 1999)

1.2 g/cm³ @ Temp: 20 °C

200°C @760 mm Hg

392 °C5 mm Hg

>230 °F

1.588

LESS THAN 1X10-4 MM HG @ 25 °C

8.6 (vs air)

ISOCYANATE EQUIVALENT 132-137 G/EQUIV; HYDROLYZABLE CHLORIDE 0.28-0.5%; ISOCYANATE CONTENT 30.5-32% MIN|ACIDITY AS HYDROCHLORIC ACID 0.2-0.3%|Boiling point is 196 °C at 5 mm Hg; melting point is 38 °C. Soluble in acetone, benzene, kerosene, nitrobenzene /Methyl Diphenyl Diisocyanate/

Reacts with water slowly forming heavy scum and liberating carbon dioxide gas. Dangerous pressure can build up if container is sealed.

Isocyanates and Isothiocyanates

Water-Reactive

POLYMERIC DIPHENYLMETHANE DIISOCYANATE reacts with water slowly forming heavy scum and liberating carbon dioxide gas. Dangerous pressure can build up if container is sealed. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence [Wischmeyer 1969].

II

6.1

NONH for all modes of transport

3

20-36/37/38-42-42/43-26-22-39/23/24/25-23/24/25-11-20/21/22

26-28-38-45-36/37-23-16-7-36

TR0350000

Xn,T+,T,F

Stable. Incompatible with strong oxidizing agents, alcohols. May decompose in moist air, or on contact with water.

P260-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311

H315-H317-H319-H332-H334-H335-H351-H373

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Methylene Bisphenyl Isocyanate (MDI) and Polymethylene Polyphenyl Isocyanate . Chemical Hazard Summary, Canadian Centre for Occupational Health and Safety, 20: (1987).|Woolrich PF; Toxicology, industrial hygiene and medical control of TDI, MDI and PMPPI. Am Ind Hyg Assoc J 43 (2): 89-97 (1982).

Behavior in Fire: Containers may explode. (USCG, 1999)

|Danger|H315 (93.48%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P260, P261, P264, P271, P272, P280, P281, P284, P285, P302+P352, P304+P312, P304+P340, P304+P341, P305+P351+P338, P308+P313, P310, P312, P314, P320, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 1787 companies from 43 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]|P261, P271, P304+P312, P304+P340, and P312|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|H315: Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P260, P261, P264, P270, P271, P272, P280, P281, P284, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P308+P313, P310, P312, P314, P320, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|H317: May cause an allergic skin reaction [Warning Sensitization, Skin]|P201, P202, P260, P261, P264, P270, P272, P273, P280, P281, P302+P352, P307+P311, P308+P313, P314, P321, P333+P313, P363, P391, P405, and P501

Air-line or organic canister mask; goggles or face shield; rubber gloves and other protective clothing to prevent contact with skin. (USCG, 1999)|Vapor Concentration: 0.2 ppm or less: Any supplied-air respirator or any self-contained breathing apparatus. 1 ppm or less: Any supplied-air respirator with a full facepiece, helmet, or hood or any self-contained breathing apparatus with a full facepiece. A type C supplied air respirator operated in a pressure-demand or other positive pressure or continuous flow mode. 20 ppm or less: A type C supplied-air respirator with a full facepiece operated in pressure-demand or other positive pressure mode or with a full facepiece, helmet, or hood operated in continuous-flow mode. Greater than 20 ppm or entry and escape from unknown concentrations: Self-contained breathing apparatus with a full facepiece operated in a pressure-demand or other positive pressure mode or a combination respirator which includes a type C supplied-air respirator with a full facepiece operated in pressure-demand or other positive pressure or continuous-flow mode and an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode. Escape: Any escape self-contained breathing apparatus. /Methyl isocyanate/

Persons involved in fighting fires should wear a self-contained breathing apparatus with a full facepiece operated in a pressure-demand or other positive pressure mode. ... /Methyl isocyanate/

IDENTIFICATION AND USE: Polymethylene polyphenyl isocyanate is a dark amber viscous liquid. It is used as a binder resin for particle board and as a foundry core binder resin. HUMAN EXPOSURE AND TOXICITY: Isocyanates are irritating to the skin and mucous membranes, the skin conditions range from localized itching to wide spread eczema. Eye affections are less common and lacrimation is noted. The incidence of conjunctivitis is rare. Isocyanates have serious effects on lung tissue. Individuals who are at risk from adverse effects of isocyanates include those with a history of asthma, allergies, impaired lung or pulmonary function. Evidence of Carcinogenicity: No evidence in humans. ANIMAL STUDIES: The increased in pulmonary adenomas in male and female Wistar rats were noted in a lifetime chronic inhalation study. In industry reports five albino rats exposed to this chemical by single doses exhibited salivation, nasal discharge and abnormal yellow discoloration. Gross necropsy revealed no abnormalities. ChR-CD male rats administered single doses of polymethylene polyphenyl isocyanate by oral gavage, gross necropsy revealed eroded and thickened stomach mucosa and masses in the stomach. Microscopic histopathology discovered depletion of thymocytes, reduced liver cell vacuolation and focal inflammation of the liver. Rabbits receiving single occluded applications of undiluted polymethylene polyphenyl isocyanate showed slight skin erythema and slight coriaceousness at the application site. No effects were observed at necropsy. Lung congestion was observed in Albino Spartan Sprague-Dawley rats exposed by inhalation to this chemical. A carcinogenicity study of polymethylene polyphenyl isocyanate in Cpb:WU, Wistar random rats exposed by inhalation showed mortality rates were negatively correlated with concentration. Effects included basal cell hyperplasia and hyperplasia of Bowman's glands in the olfactory epithelium of the nose, alveolar duct epithelia, alveolar duct fibrosis in tissues surrounding macrophage accumulations. Increases in lung weights along with calcerous particles in lungs and localized areas of bronchiolisation and pulmonary adenomas and a pulmonary adenocarcinoma were noted. In Long-Evans rats exposed by inhalation of polymethylene polyphenyl isocyanate vapors clinical observations included respiratory distress in the form of rales. Gross necropsy revealed no treatment changes. In Salmonella typhimurium tester strains TA1535, TA1537 and TA1538 (Ames test) with or without metabolic activation did not produce positive results in any strain tested.

Persons with a history of asthma, allergies ... or impaired lung or pulmonary function may be at an increased risk. /Methyl isocyanate/

Inhalation causes breathlessness, chest discomfort, and reduced pulmonary function; wheezing, cough, and sputum may also occur. Contact with liquid irritates eyes and skin. Ingestion causes irritation of mouth and stomach. (USCG, 1999)

Get medical attention at once following all exposures to this compound. INHALATION: remove victim to fresh air; give artificial respiration if breathing has stopped; oxygen can be given by qualified personnel. EYES: immediately wash with large amounts of water for at least 15 min. SKIN: flush immediately with water, wipe off, treat with 30% isopropyl alcohol (rubbing alcohol), and wash with soap and water. INGESTION: induce vomiting at least 3 times by giving warm salt water (one tablespoon of salt per cup); follow with a quart of milk and a mild carthartic such as milk of magnesia. (USCG, 1999)

Noncardiogenic pulmonary edema and bronchospasm are the most immediate serious clinical consequences of isocyanate exposure. Markedly symptomatic patients should receive oxygen, ventilatory support, and an intravenous line. Treatment for asthma includes inhaled sympathomimetics (salbutamol, metaproterenol), intravenous theophylline, parenteral sympathomimetics (epinephrine, terbutaline), and steroids. /Isocyanates/|Most treatment is symptomatic. Mydriatics, systemic analgesics, and topical antibiotics (Sulamyd) may be used for corneal abrasions. There is no effective therapy for sensitized workers, and these people should be moved to a work site devoid of exposure to isocyanates. /Isocyanates/

Isocyanates are irritating to the skin and the mucous membranes, the skin conditions ranging from localized itching to more or less widespread eczema. Eye affections are less common and, although lacrimation is often found, conjunctivitis is rare. The commonest and most serious troubles, however, are those affecting the respiratory systems. /Isocyanates/

polymethylene polyphenylisocyanate

ALMOST EXCLUSIVELY AS A MONOMER WITH POLYETHER & POLYESTER POLYOLS TO PRODUCE POLYURETHANE PRODUCTS, OF WHICH ABOUT 81% ARE RIGID FOAMS, ABOUT 8% ARE FLEXIBLE FOAMS, ABOUT 8% ARE ADHESIVES, FOUNDRY RESINS, & RIGID RIM (STRUCTURAL FOAMS), AND ABOUT 3% ARE ELASTOMERS (1975)|END USE PATTERN (DERIVATIVE): BUILDING CONSTRUCTION, 45%; APPLIANCES, 15%; TRANSPORTATION, 10%; FURNITURE, 5%; PACKAGING, 5%; PLASTICS & ELASTOMERS, 15%; MISC, 5% (1983)

All other chemical product and preparation manufacturing|Isocyanic acid, polymethylenepolyphenylene ester: ACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).|A POLYMER OF DIPHENYLMETHANE 4,4'-DIISOCYANATE...|POLYMETHYLENE POLYPHENYL ISOCYANATE WAS USED FOR PRODUCTION OF POLYURETHANE RIGID FOAM (80.4-82.8%), POLYURETHANE FLEXIBLE FOAMS (7.6-8.5%), POLYURETHANE ELASTOMERS (2.7-3.2%) & OTHER POLYURETHANE APPLICATIONS (7.1-7.9%).|CROSS-LINKED, NYLON-TYPE POLYMER PREPD BY REACTION OF MIXT OF SEBACOYL CHLORIDE & POLYMETHYLENE POLY(PHENYLISOCYANATE) WITH MIXT OF ETHYLENEDIAMINE & DIETHYLENETRIAMINE IS EXEMPTED FROM REQUIREMENT OF TOLERANCE WHEN USED AS ENCAPSULATING MATERIAL FOR METHYL PARATHION.|Polymethylene polyphenyl isocyanate is a crude product which varies in its exact composition. The main constituents are 40-60% 4,4'-MDI; the remainder is the other isomers of MDI, trimeric species and higher molecular weight oligomers.|CONTROLLED-RELEASE PESTICIDE GRANULES ARE PREPD BY USING POLYISOCYANATES OR POLYISOCYANATE PREPOLYMERS AS MAIN FORMULATION INGREDIENT.

ALIPHATIC & AROMATIC ISOCYANATES & THEIR OLIGOMERS WERE DETECTED IN AIR BY HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY USING 2X10-4 MOLAR SOLN OF 1-(2-PYRIDYL)PIPERAZINE IN METHYL PHENYL AT RATE OF 1 L/MIN FOR 5-20 MIN. SAMPLES FROM TLC PLATES WERE DETECTED WITH IODOPLATINATE.|Samples were analyzed using gel permeation of normal phase high pressure liquid chromatography with fluorescence detection after the derivatization with tryptamine. The minimum identifiable amount was about 2 ug.|Sample collected on a glass fiber filter coated with N-)p-nitrobenzyl)-N-n-propylamine as an in situ derivatizing agent. The resulting derivative is extracted with tetrahydrofuran, treated successively with acetyl chloride and methanol and anlyzed by size exclusion liquid chromatography using UV-visible detector at 254 nm. Decteion range 2-155 ppb in air for a 45 L air sample.