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MEDICA16

MEDICA16 structure

CAS No:
87272-20-6
Formula:
C20H38O4
Chemical Name:
MEDICA16
Synonyms:
MEDICA 16;3,3,14,14-TETRAMETHYLHEXADECANEDIOIC ACID;3,3,14,14-TETRAMETHYLHEXADECANEDIONIC ACID;Hexadecanedioic acid, 3,3,14,14-tetramethyl-
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

MEDICA 16 is an alpha,omega-dicarboxylic acid that is hexadecanedioic acid carrying methyl groups at positions 3 and 14. It is a free fatty acid 1 (FFA1/GPR40) receptor agonist and an ATP citrate lyase inhibitor, and exhibits hypolipidemic and antidiabetogenic properties. It has a role as an antilipemic drug, an EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor, an EC 2.3.3.8 (ATP citrate synthase) inhibitor, a G-protein-coupled receptor agonist and a hypoglycemic agent.

MEDICA16 Basic Attributes

Molecular Weight：

342.51

Exact Mass：

342.27700969 g/mol

UNII：

TC257FLPCK

DSSTox ID：

DTXSID00236246

Characteristics

PSA：

74.6 Å²

Density：

0.984±0.06 g/cm3

Melting Point：

154-159 °C

Boiling Point：

485.9±18.0 °C(Predicted)

PKA：

4.51±0.10

Safety Information

wgk germany：

Drug Information

MeSH：

Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)

MeSH Entry Terms：

3,3,14,14-tetramethylhexanedecanedioic acid

MEDICA16 Use and Manufacturing

MEDICA 16 is a β,β'-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.

Computed Properties

Molecular Weight:342.5
XLogP3:7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:15
Exact Mass:342.27700969
Monoisotopic Mass:342.27700969
Topological Polar Surface Area:74.6
Heavy Atom Count:24
Complexity:336
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes