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Home > Encyclopedia > Trovafloxacin mesylate

Trovafloxacin mesylate

Trovafloxacin mesylate structure

Trovafloxacin mesylate 

structure
  • CAS No:

    147059-75-4

  • Formula:

    C20H15F3N4O3.CH4O3S

  • Chemical Name:

    Trovafloxacin mesylate

  • Synonyms:

    1,8-Naphthyridine-3-carboxylic acid,7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-,methanesulfonate (1:1);1,8-Naphthyridine-3-carboxylic acid,7-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-,(1α,5α,6α)-,monomethanesulfonate;3-Azabicyclo[3.1.0]hexane,1,8-naphthyridine-3-carboxylic acid deriv.;CP 99219;Trovafloxacin mesylate;CP 99219-27;Trovafloxacin monomethanesulfonate;Trovan;Trovafloxacin methanesulfonate;146836-84-2

Description

Trovafloxacin mesylate is a methanesulfonate (mesylate) salt prepared from equimolar amounts of trovafloxacin and methanesulfonic acid. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure. It has a role as an antibacterial drug, an antimicrobial agent, a DNA synthesis inhibitor, a hepatotoxic agent and a topoisomerase IV inhibitor. It contains a trovafloxacin(1+).

Trovafloxacin mesylate Basic Attributes

512.45900

512.09774000 g/mol

0P1LKO80WN

DTXSID0045701

J01MA13

Characteristics

164.20000

3.24460

635ºC

335.1ºC

2.59E-24mmHg at 25°C

Safety Information

|Danger|H314 (97.44%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P201, P202, P260, P264, P280, P281, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P321, P363, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Trovafloxacin is a synthetic broad spectrum quinolone antibacterial agent indicated for the treatment of the following infections in adults:Pneumonia: Community Acquired Pneumonia and Nosocomial Pneumonia (mild, moderate, and severe).Note: Efficacy in patients with very severe nosocomial pneumonia and in particular infections due to less susceptible pathogens e.g. P. aeruginosa, has not been established. See also section 4.2.Acute Exacerbations of Chronic BronchitisAcute SinusitisComplicated Intra-abdominal Infections and Acute Pelvic InfectionsSalpingitisUncomplicated Gonococcal Urethritis and CervicitisChlamydial CervicitisComplicated Skin and Soft Tissue InfectionsConsideration should be given to official guidance on the appropriate use of antibacterial agents.|Trovafloxacin is a synthetic broad spectrum quinolone antibacterial agent indicated for the treatment of the following infections in adults:Pneumonia:Community Acquired Pneumonia and Nosocomial Pneumonia (mild, moderate, and severe).Note: Efficacy in patients with very severe nosocomial pneumonia and in particular infections due to less susceptible pathogens e.g. P. aeruginosa, has not been established. See also section 4.2.Acute Exacerbations of Chronic BronchitisAcute SinusitisComplicated Intra-abdominal Infections and Acute Pelvic InfectionsSalpingitisUncomplicated Gonococcal Urethritis and CervicitisChlamydial CervicitisComplicated Skin and Soft Tissue InfectionsConsideration should be given to official guidance on the appropriate use of antibacterial agents.

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)|Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)

CP 99,219|alatrofloxacin

Trovafloxacin mesylate Use and Manufacturing

Human drugs -> Turvel -> EMA Drug Category|Antibacterials for systemic use -> Human pharmacotherapeutic group|Human drugs -> Trovan -> EMA Drug Category|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:512.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:3
Exact Mass:512.09774000
Monoisotopic Mass:512.09774000
Topological Polar Surface Area:163
Heavy Atom Count:35
Complexity:863
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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