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RUBOXISTAURIN MESYLATE

RUBOXISTAURIN MESYLATE structure

CAS No:
169939-94-0
Formula:
C28H28N4O3
Chemical Name:
RUBOXISTAURIN MESYLATE
Synonyms:
9H,18H-5,21:12,17-Dimethenodibenzo(E,K)pyrrolo(3,4-H)(1,4,13)oxadiazacyclohexadecine-18,20(19H)-dione, 9-((dimethylamino)methyl)-6,7,10,11-tetrahydro-, (9S)-;Unii-721809wqcp;Ruboxistaurin (LY333531);Ruboxistaurin (LY333531) (HCl salt);RUBOXISTAURIN MESYLATE;(S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione;LY 333531;13-((Dimethylamino)methyl)-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo(E,K)pyrrolo(3,4-H)(1,4,13)oxadiazacyclohexadecene-1,3(2H)-dione

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Description

Ruboxistaurin has been investigated for the basic science of Type 2 Diabetes Mellitus and Type 1 Diabetes Mellitus.

RUBOXISTAURIN MESYLATE Basic Attributes

Molecular Weight：

468.55

Exact Mass：

468.55

UNII：

721809WQCP

DSSTox ID：

DTXSID00168775

Color/Form：

Brown to reddish brown

Characteristics

PSA：

68.5 Å²

Density：

1.34

Boiling Point：

744.4±60.0 °C(Predicted)

PKA：

8.26±0.40(Predicted)

Critical Temperature & Pressure：

Store at -20°C

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

Metabolism/Metabolites：

Ruboxistaurin has known human metabolites that include N-desmethyl LY333531.

MeSH Entry Terms：

13-((dimethylamino)methyl)-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo(e,k)pyrrolo(3,4-h)(1,4,13)oxadiazacyclohexadecene-1,3(2H)-dione

RUBOXISTAURIN MESYLATE Use and Manufacturing

Ruboxistaurin is a protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). Ruboxistaurin is used in treatment of diabetic microvascular complications.

Computed Properties

Molecular Weight:468.5
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:468.21614077
Monoisotopic Mass:468.21614077
Topological Polar Surface Area:68.5
Heavy Atom Count:35
Complexity:872
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of RUBOXISTAURIN MESYLATE

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

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