2-hydroxyethanesulfonic acid;9-[4-(methanesulfonamido)-2-methoxyanilino]-N,5-dimethylacridine-4-carboxamide
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![2-hydroxyethanesulfonic acid;9-[4-(methanesulfonamido)-2-methoxyanilino]-N,5-dimethylacridine-4-carboxamide structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/7f6666a45b8f48a89ee413defd5388a7.png "2-hydroxyethanesulfonic acid;9-[4-(methanesulfonamido)-2-methoxyanilino]-N,5-dimethylacridine-4-carboxamide")
2-hydroxyethanesulfonic acid;9-[4-(methanesulfonamido)-2-methoxyanilino]-N,5-dimethylacridine-4-carboxamide
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CAS No:
80841-48-1
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Formula:
C26H30N4O8S2
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Chemical Name:
2-hydroxyethanesulfonic acid;9-[4-(methanesulfonamido)-2-methoxyanilino]-N,5-dimethylacridine-4-carboxamide
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Synonyms:
4-Acridinecarboxamide, 9-((2-methoxy-4-((methylsulfonyl)amino)phenyl)amino)-N,5-dimethyl-;asulacrine;CI 921;CI-921;N-5-dimethyl-9-((2-methoxy-4-methylsulfonylamino)phenylamino)-4-acridinecarboxamide;NSC 343499;NSC-343499;Amsalog;Asulacrine isethionate;80841-48-1;UNII-649R3P169I;NSC 343499;649R3P169I;NSC-343499;Neuro_000177;SCHEMBL1649484;CHEMBL1983722;DTXSID60230664;NSC343499;Ethanesulfonic acid, 2-hydroxy-, compd. with 9-((2-methoxy-4-((methylsulfonyl)amino)phenyl)amino)-N,5-dimethyl-4-acridinecarboxamide (1:1);NCI60_003048;Q27263737;Ethanesulfonic acid, compd. with 9-[[2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino]-N,5-dimethyl-4-acridinecarboxamide (1:1)
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CAS No:
Description
Asulacrine Isethionate is the isethionate salt of an amsacrine analogue with antineoplastic properties. Asulacrine inhibits the enzyme topoisomerase ll, thereby blocking DNA replication and RNA and protein synthesis.
2-hydroxyethanesulfonic acid;9-[4-(methanesulfonamido)-2-methoxyanilino]-N,5-dimethylacridine-4-carboxamide Basic Attributes
590.7 g/mol
590.15050628 g/mol
649R3P169I
343499
DTXSID60230664
C1050
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)
4-Acridinecarboxamide, 9-((2-methoxy-4-((methylsulfonyl)amino)phenyl)amino)-N,5-dimethyl-
Computed Properties
Molecular Weight:590.7
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:8
Exact Mass:590.15050628
Monoisotopic Mass:590.15050628
Topological Polar Surface Area:201
Heavy Atom Count:40
Complexity:905
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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