Dihydroergotamine mesylate
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Dihydroergotamine mesylate
structure -
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CAS No:
6190-39-2
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Formula:
C33H37N5O5.CH4O3S
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Chemical Name:
Dihydroergotamine mesylate
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Synonyms:
Ergotaman-3′,6′,18-trione,9,10-dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)-,(5′α,10α)-,methanesulfonate (1:1);Ergotaman-3′,6′,18-trione,9,10-dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)-,(5′α,10α)-,monomethanesulfonate (salt);Ergotamine,9,10-dihydro-,monomethanesulfonate (salt);Dihydroergotamine mesylate;Dihydroergotamine methanesulfonate;Dihydroergotamine methanesulphonate;Dihytamine;DHE 45;Dihydergot;DETMS;9,10-Dihydroergotamine mesylate;Dihydroergotamine monomethanesulfonate;(+)-Dihydroergotamine mesylate;Seglor;Dirgotarl;Morena;Orstanorm;Ergotonin;Ikaran;Tonopres;Diergo;Ergomimet;Endophleban;Migranal;Agit;Dergotamine;Ergont;Angionorm;Verladyn;122074-71-9;37-48-9;1381-02-8;5707-14-2;11041-28-4;56532-69-5;885319-97-1
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Dihydroergotamine mesylate is an ergot alkaloid used to treat migraines.Target: 5-HT ReceptorsDihydroergotamine is not as effective as sumatriptan or phenothiazines as a single agent for treatment of acute migraine headache; however, when administered with an antiemetic, dihydroergotamine appears to be as effective as opiates, ketorolac, or valproate. Given its nonnarcotic properties, parenteral dihydroergotamine combined with an antiemetic should be considered as effective initial thera
Dihydroergotamine mesylate is the methanesulfonic acid salt of dihydroergotamine, a semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine. Both the mesylate and the tartrate salts are used for the treatment of migraine and orthostatic hypotension. It has a role as a serotonergic agonist, a non-narcotic analgesic and a vasoconstrictor agent. It contains a dihydroergotamine.|Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. Dihydroergotamine mesylate most likely relieves migraine headaches by binding to and stimulating the 5-HT1D receptor subtype, thereby causing constriction of cerebral blood vessels. However, it has also been proposed that dihydroergotamine mesylate acts upon 5-HT1D receptors on sensory nerve endings of the trigeminal system, thereby decreasing the release of pro-inflammatory neuropeptide release.|A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.
Dihydroergotamine mesylate Basic Attributes
679.78
679.267578
228-235-6
81AXN7R2QT
759848
C47491
2939690000
Characteristics
180.96000
2.87050
white powder
230-235 °C
1001.8ºC at 760 mmHg
559.7ºC
-20 ° (C=0.25, JP Method)
methanol: 21 mg/mL
Store at RT
227.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
III
6.1(b)
1544
3
20/21/22
36
KE7920000
Xn
P280
H312-H332
|Warning|H312 (88%): Harmful in contact with skin [Warning Acute toxicity, dermal]|P261, P271, P280, P302+P352, P304+P312, P304+P340, P312, P322, P363, and P501|Aggregated GHS information provided by 50 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)|Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)|A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)
Agit
Dihydroergotamine mesylate Use and Manufacturing
vasoconstrictor, antimigraine
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:679.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:679.26758446
Monoisotopic Mass:679.26758446
Topological Polar Surface Area:181
Heavy Atom Count:48
Complexity:1260
Defined Atom Stereocenter Count:7
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Not yet clear
Registered Holders
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OLON S.P.A.
Active
Italy
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TAPI NL B.V.
Active
France
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TAPI CZECH INDUSTRIES S.R.O.
Active
European Union
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