Propylene glycol dinitrate

166.09

166.09

229-180-0

1392

62614

DTXSID7027627

Red-orange liquid

2920909090

110.10000

0.83790

Propylene glycol dinitrate is a colorless liquid with a disagreeable odor. Mp: -30°C. Density 1.37 g/cm3 at 20°C. Slightly soluble in water (7.97 g/L H2O at 24.85°C).

1.2 g/cm³ @ Temp: 25 °C

18°F

59-60 °C @ Press: 0.5 Torr

98.5ºC

1.451

0.1%

(72°F): 0.07 mmHg

Relative vapour density (air = 1): 5.73

Combustible Liquid

3.20e-13 cm3/molecule*sec

Henry's Law constant = 9.4X10-7 atm-cu m/mol @ 25 °C /Estimated/|Henry's Law constant is approx 1X10-2 atm-cu m/mole /Azeotrope/

Hydroxyl radical reaction rate constant = 3.2X10-13 cu cm/molec-sec @ 25 °C

No rapid reaction with air No rapid reaction with water Soluble in water

Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

Explosive

PROPYLENE GLYCOL DINITRATE is explosive. Acts as a strong oxidizing agent. Heating may cause a violent combustion or explosion producing toxic fumes (nitrogen oxides). May also decompose explosively from shock, friction or from a build-up of electrostatic charge that sparks suddenly to ground. Can begin a vigorous reaction that culminates in an explosion if mixed with reducing agents including hydrides, sulfides, and nitrides and numerous ordinary combustible materials. Reacts violently with Al, BP, cyanides, esters, PN2H, P, NaCN, SnCl2, sodium hypophosphite, and thiocyanates. Reacts with acids and with alkalis, including ammonia and amines. Must be stored in a cool, ventilated place, away from acute fire hazards and easily oxidized materials.

Combustible Liquid

1.1A

0473

TY6300000

Fireproof.

It is unstable under ordinary conditions, but it is stabilized by small additions of 2-nitrodiphenylamine and di-n-butyl sebacate .

P260, P264, P270, P301+P312, P307+P311, P309+P311, P314, P321, P330, P405, P501

H302

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|Biodegradation studies have provided conflicting evidence of the biodegradability of propylene glycol dinitrate ... by conventional sewage treatment methods. Suggested alternative treatment methods have included carbon absorption techniques combined with base hydrolysis of propylene glycol dinitrate to the biodegradable propylene glycol, and decomposition of propylene glycol dinitrate using sodium sulfide. Bench-scale wet air oxidation screening tests conducted at 280 C for 60 minutes indicate excellent removal of propylene glycol dinitrate from waste streams that are too dilute to incinerate and too toxic to biotreat.

Ammonia compounds, amines, oxidizers, reducing agents, combustible materials ... Similar to ethylene glycol dinitrate in explosion potential.|Heating may cause violent combustion or explosion. May explosively decompose on shock, friction, or concussion.

DHHS/ATSDR; Toxicological Profile for Otto Fuel II and its components (June 1995). Available from: http://www.atsdr.cdc.gov/toxprofiles/tp77.html as of February 17, 2003.

Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion. Explosive.

|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P301+P312, P307+P311, P309+P311, P314, P321, P330, P405, and P501

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: No recommendation is made specifying the need for washing the substance from the skin (either immediately or at the end of the work shift). Remove: No recommendation is made specifying the need for removing clothing that becomes wet or contaminated. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|Face shield, or eye protection in combination with breathing protection. Protective gloves. Protective clothing.|(See protection codes)

/To Fight fire use/ powder, water spray, foam, carbon dioxide.|In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

Evacuate danger area! Consult an expert! Remove all ignition sources. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. (Extra personal protection: complete protective clothing including self-contained breathing apparatus.)

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Mildly irritating upon direct contact.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.05 ppm (0.3 mg/cu m). Skin designation.

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Fireproof.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.

The substance is mildly irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. Medical observation is indicated.

NO open flames, NO sparks and NO smoking. Do NOT expose to friction or shock.

STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Grab samples of air in four U.S. Navy torpedo facilities (Naval Weapons Station, Charleston, South Carolina; Naval Weapons Station, Yorktown, Virginia; Naval Submarine Support Facility, New London, Connecticut; and Naval Torpedo Station, Keyport, Washington) had levels of 1,2-propanediol dinitrate ranging from 0 to 0.22 ppm(1).

LD50 Mouse subcutaneously >1200 mg/kg|LD50 Rat subcutaneously 530 mg/kg|LD50 Rat oral 250 mg/kg|LD50 Rat ip 479 mg/kg|For more Non-Human Toxicity Values (Complete) data for 1,2-PROPANEDIOL DINITRATE (6 total), please visit the HSDB record page.

1,2-Propanediol dinitrate's production and use as a component of the naval torpedo fuel Otto II(1,2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 68(SRC), determined from a structure estimation method(2), indicates that 1,2-propanediol dinitrate is expected to have high mobility in soil(SRC). Volatilization of 1,2-propanediol dinitrate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.4X10-7 atm-cu m/mole(SRC), calculated using a fragment constant estimation method(3). 1,2-Propanediol dinitrate forms an azeotrope with water resulting in enhanced volatilization from water(4), but it is unclear whether this will be important in moist soils(SRC). 1,2-Propanediol dinitrate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.38 mm Hg(SRC), determined from a fragment constant method(5). 1,2-Propanediol dinitrate was poorly biodegraded using an activated sewage sludge, a pure culture of Pseudomonas aeruginosa, and a commercially available inoculum employed for the degradation of nitrogen containing wastes(4), suggesting biodegradation in soil will be slow(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 68(SRC), determined from a structure estimation method(2), indicates that 1,2-propanediol dinitrate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 9.4X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4); however, laboratory studies have shown that 1,2-propanediol dinitrate forms an azeotrope with water resulting in enhanced volatilization(5). The Henry's Law constant for the azeotrope was estimated to be about 1X10-2 atm-cu m/mole(5). Based on the Henry's Law constant for the azeotrope, the volatilization half-life from a model river and a model lake are estimated as 2 hours and 5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from an estimated log Kow of 1.59(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 1,2-Propanediol dinitrate was poorly biodegraded using an activated sewage sludge, a pure culture of Pseudomonas aeruginosa, and a commercially available inoculum employed for the degradation of nitrogen containing wastes(5), suggesting biodegradation in water will be slow(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,2-propanediol dinitrate, which has an estimated vapor pressure of 0.38 mm Hg at 25 °C (SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,2-Propanediol dinitrate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 50 days(SRC), calculated from its rate constant of 3.2X10-13 cu cm/molecule-sec at 25 °C(3).

The rate constant for the vapor-phase reaction of 1,2-propanediol dinitrate with photochemically-produced hydroxyl radicals has been measured as 3.2X10-13 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 50 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1,2-Propanediol dinitrate is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2). When irradiated with polychromatic light, 1,2-propanediol dinitrate was shown to decompose to lactic and pyruvic acid(3), however this reaction is not expected to be environmentally significant since this compound does not absorb light in the environmental UV (> 290 nm) spectrum(SRC).

An estimated BCF of 3 was calculated for 1,2-propanediol dinitrate(SRC), using an estimated log Kow of 1.6(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 1,2-propanediol dinitrate can be estimated to be 68(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1,2-Propanediol dinitrate is expected to have high mobility in soil(SRC).

The Henry's Law constant for 1,2-propanediol dinitrate is estimated as 9.4X10-7 atm-cu m/mole(SRC) calculated using a fragment constant estimation method(1). This Henry's Law constant indicates that 1,2-propanediol dinitrate is not expected to volatilize from moist soil or water surfaces(2). Laboratory experiments using 10 ml of Otto fuel II (76% 1,2-propanediol dinitrate, 22.5% dibutyl sebacate, and 1.5% 2-nitrodiphenylamine) added to an unspecified amount of water showed that 1,2-propanediol dinitrate in solution does not obey ideal solution behavior and there is a positive deviation in Raoult's Law due to the formation of an azeotrope with water(3). This resulted in the unexpected volatilization of 1,2-propanediol dinitrate from water under aerated laboratory conditions(3). The Henry's law constant for the azeotrope was estimated to be about 1X10-2 atm-cu m/mole(3). Based on the Henry's Law constant for the azeotrope, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 5 days(SRC). 1,2-Propanediol dinitrate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.38 mm Hg(SRC), determined from a fragment constant method(4).

Occupational exposure to 1,2-propanediol dinitrate may occur through inhalation and dermal contact with this compound at workplaces where 1,2-propanediol dinitrate or Otto fuel II is produced or used(SRC). 1,2-Propanediol dinitrate was monitored as an indicator of exposure to Otto Fuel II at four naval facilities(1). A level of 0.001 ppm was measured in the breath of one of the workers 5 minutes after exposure to air concentrations ranging from 0.01 to 0.026 ppm ceased. No 1,2-propanediol dinitrate was detected 15 minutes after exposure ceased. In the second worker, concentrations of 0.0008 and 0.0004 ppm were measured in the expired air 5 and 15 minutes, respectively, after exposure to 0.015-0.222 ppm of Otto fuel II(1).

The substance can be absorbed into the body by inhalation, through the skin or by ingestion.|Information supporting the dermal absorption of propylene glycol dinitrate was obtained from studies demonstrating systemic toxicity after dermal exposure in rabbits For example, a transient decrease in hemoglobin was observed following dermal application of doses of propylene glycol dinitrate as low as 1,000 mg/kg/day, 2 hours/day, for 20 days to rabbits. Also, observation of elevated levels of the metabolite nitrate in the urine of rabbits receiving a dermal dose of 4,000 mg/kg/day supported the absorption of propylene glycol dinitrate after dermal exposure.|Exposure of monkeys to concentrations of 1.6 ppm and 4.2 ppm of propylene glycol dinitrate for 20 and 14 days, respectively, resulted in the detection of small amounts of propylene glycol dinitrate in plasma. During exposures to 1 .6 ppm, 35 ug/mL propylene glycol dinitrate was detected in plasma, and during exposures at 4.2 ppm, 170 ug/mL was detected in plasma.|In vitro studies using dog blood have shown that propylene glycol dinitrate preferentially associates with red blood cells in the blood.|For more Absorption, Distribution and Excretion (Complete) data for 1,2-PROPANEDIOL DINITRATE (6 total), please visit the HSDB record page.

The metabolism of /propylene glycol, 1,2-dinitrate/ (PGDN), as determined in vitro in blood and in vivo in rats, showed that 50% was broken down in 1 hr, and 50% of the remainder in the following hour. Small concentrations of inorganic nitrite were produced during incubation in blood, whereas inorganic nitrate accumulated. At the end of 3 hr, the first time it was measured, there were large amounts of propylene glycol 2-mononitrate (PGMN-2), together with small amounts of PGMN-1). The summed quantities of mononitrates, inorganic nitrate, and nitrite represented 95% of the initial amount added to blood. this metabolism occurred in the erythrocytes. In the intact rat, in contrast to in vitro in the blood, mononitrates undergo further degradation to nitrogen compounds other than the mononitrates and inorganic nitrate. Only 56% of the administered PGDN appeared in the urine as inorganic nitrate. THus, there is qualitatively little to distinguish the in vitro and in vivo metabolism of PGDN from that of /ethylene glycol dinitrate/ (EGDN). The only difference is that PGDN gives rise to two mononitrates and the 2-isomer is predominant, whereas EGDN gives rise only to /ethylene glycol mononitrate/. Quantitatively, there is less dinitrate and inorganic nitrite in the bloodstream after subcutaneous injection from PGDN than from a comparable injection of EGDN. Excretion was complete in 24 hr following a 65 mg/kg PGDN subcutaneous injection in rats.|Metabolic studies show that inorganic nitrate /is/ the major metabolite of propylene glycol dinitrate (PGDN) in rats administered 65 mg/kg subcutaneously; PGDN and nitrite were almost undetectable. Excretion was complete in 24 hours.|... An effort was made to understand the oxidative process /which produces methemoglobin in vivo/ better and explain the role of hemoglobin in detoxifying nitrate esters. The reaction was nonenzymatic and first-order for dinitrate and O2Hb. The rate of oxidation proceeds linearly with dinitrate concentration and does not approach a limit as would be the case if it were enzymatically driven. The rate of oxidation is related complexly to the oxygen concentration. No oxidation occurs at zero oxygen concentration and none at very high concentrations. The stoichiometry was thought to be 1.5 hemes oxidized per ester bond broken in hemolysates and 1.9 to 2.3 per mole reacted ester in whole cells. From these studies, it was reasoned that hemoglobin would fulfill an important role in detoxifying the effects caused by the dinitrates. Hemoglobin in vivo, with the methemoglobin reductase system, acts catalytically to metabolize dinitrates to nitrite and nitrate, and the mononitrates are further degraded by the denitrifying tissue enzymes.|Subcutaneous injection of 65 mg/kg propylene glycol dinitrate in rats caused a rapid increase in blood levels of propylene glycol dinitrate. Appearance of metabolites of propylene glycol dinitrate in the blood was maximal 2-4 hours postinjection and had declined to essentially zero by 8-12 hours postinjection. The predominant metabolite observed in the blood was nitrate, with propylene glycol 2-mononitrate observed at approximately one-half the concentration of inorganic nitrate. The levels of propylene glycol 1-mononitrate and inorganic nitrite were less than half that of propylene glycol 2-mononitrate.|For more Metabolism/Metabolites (Complete) data for 1,2-PROPANEDIOL DINITRATE (6 total), please visit the HSDB record page.

The metabolism of /propylene glycol, 1,2-dinitrate/, as determined in vitro in blood and in vivo in rats, showed that 50% was broken down in 1 hr, and 50% of the remainder in the following hour.|For /intravenous/ doses of 0.3, 3, and 30 mg/kg /in rats/, the elimination half-time of propylene glycol dinitrate was 8.8, 13.1, and 17.4 hours, respectively. Elimination of the parent compound from blood was monoexponential.

The mechanism of propylene glycol dinitrate toxicity is related to its vasodilating capacity. Propylene glycol dinitrate is an organic nitrate and shares many of the cardiovascular properties of therapeutic nitrates Organic nitrates induce peripheral vasodilation, decreased ventricular ejection time, relaxation, and a longer period of coronary blood flow. One of the earliest consequences of overexposure to propylene glycol dinitrate is a vasodilation of the cerebral vessels Should the overexposure be more severe, the relaxation of the vascular smooth muscle can result in a fall in blood pressure followed by a compensatory vasoconstriction.

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Irritation eyes; conjunctivitis; methemoglobinemia; headache, impaired balance, visual disturbance Target Organs: Eyes, central nervous system, blood, liver, kidneys (NIOSH, 2016)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, wash the contaminated skin with soap and water. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Maintain an open airway and assist ventilation if necessary. administer supplemental oxygen. Treat hypotension with supine positioning, crystalloid intravenous fluids, and low-dose pressors if needed. Monitor vital signs and ECG for 4-6 hours. Symptomatic methemoglobinemia may be treated with methylene blue. Administer activated charcoal if available. /Nitrates and Nitrites/|Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat as necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 d of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Nitrates, nitrites, and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Monitor cardiac rhythm and treat arrhythmias if necessary. Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present For hypotension with signs of hypovolemia, administer fluid cautiously. If unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Nitrates, nitrites, and related compounds/

/HUMAN EXPOSURE STUDIES/ Human volunteers who repeatedly inhaled propylene glycol dinitrate (PGDN) at 0.2 ppm or higher experienced disruption in the organization of the visual evoked response and headache in the majority of the subjects. Those exposed repeatedly at 0.2 ppm for 8 hours daily developed a tolerance to headache; however, alteration in the visual evoked response appeared cumulative. At 0.5 ppm, marked impairment in balance was manifest after 6.5 hours, and 40 minutes of exposure at 1.5 ppm induced ocular irritation. These symptoms resembled the ataxia seen in these same subjects at 100 to 150 mg/ 10 ml. There was, however, a consistent elevation of the diastolic blood pressure in those normotensive subjects exposed to PGDN at 0.5 pp for 8 hours; ... There was no evidence of a significant biochemical or hematologic effect in these male volunteers.|/HUMAN EXPOSURE STUDIES/ ...A group of 87 Navy personnel who were designated as "chronically exposed" to /propylene glycol, 1,2-dinitrate/ (PGDN) /were studied/. Of these, 29 were tested before and immediately after PGDN exposure during routine torpedo maintenance procedures called "turnarounds". Twenty-one nonexposed controls were similar in sex distribution, race, smoking habits, and caffeine intake; however, the exposed group consumed more than twice as much alcohol as controls. Alcohol is regarded as a substance that aggravates the toxicity of aliphatic nitrates. The duration of exposure of the entire group averaged 47.4 months, and the range was 1-132 months. Air samples were taken during each turnaround procedure. Concentrations ranged from 0.00 to 0.22 ppm and the mean concentration was 0.03 ppm. Only one sample exceeded the then current TLV of 0.2 ppm, and 87.5% of all peak concentrations were equal to or less than one-half the TLV. Neurological tests performed on the chronically exposed Otto fuel workers showed no statistically significant differences from controls. These findings also held for a subgroup of workers who had a longer mean exposure duration of almost 8 years (range of 5 to 11 years). However, quantitative eye tracking tests conducted for 29 turnarounds, showed a significant decrease (p=0.03) in the velocity of eye movement and in latency (p=0.04) when tested before and directly after exposure. Apparent alterations in standing behavior (on one leg for 30 sec) were of questionable significance.|/HUMAN EXPOSURE STUDIES/ .../Propylene glycol, 1,2-dinitrate/ (PGDN) increases the risk of cardiovascular disease through attacks due to nitrate withdrawal 1 to 3 days after last exposure and through a long-term risk which persists long after exposure ceases. The short-term risk was noted first and termed "Monday morning angina." This includes findings of angina, myocardial infarction, arrythmia, and sudden death. Generally, symptoms are not induced by exercise or psychic arousal, and no vascular lesions were found at autopsy.|/HUMAN EXPOSURE STUDIES/ Experimental exposure of volunteers to atmospheres of propylene glycol dinitrate resulted in headaches of presumed vascular origin. The headaches began as mild frontal headaches and became progressively worse and throbbing in nature. Headaches were reported by some subjects exposed to concentrations of propylene glycol dinitrate as low as 0.2 ppm for up to 8 hours. With repeated exposures, the severity and frequency of headaches was observed to decrease. By analogy with the effects of other aliphatic nitrates, the headaches are most likely the result of vasodilation of the meningeal blood vessels.|For more Human Toxicity Excerpts (Complete) data for 1,2-PROPANEDIOL DINITRATE (7 total), please visit the HSDB record page.

1,2-PGDN

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.|inhalation, skin absorption, ingestion, skin and/or eye contact

irritation eyes; conjunctivitis; methemoglobinemia; headache, impaired balance, visual disturbance; In Animals: liver, kidney damage

Blue lips, fingernails and skin. Confusion. Convulsions. Dizziness. Headache. Nausea. Unconsciousness.

MAY BE ABSORBED! See Inhalation.

Redness. Pain.

Eyes, central nervous system, blood, liver, kidneys

1,2-Propanediol, 1,2-dinitrate: ACTIVE

Method: Piezoelectric crystal; Analyte: propylene glycol dinitrate; Matrix: air; Detection Level: less than 0.05 ppm. /From table/|Method: Gas Chromatography/Thermal Energy Analyzer; Analyte: propylene glycol dinitrate; Matrix: air; Detection Level: 0.1 ug/mL. /From table/|Method: High Performance Liquid Chromatography/Electrochemical Detection; Analyte: propylene glycol dinitrate; Matrix: air; Detection Level: 0.2 ug/mL. /From table/|Method: Linear Sweep Voltammetry; Analyte: propylene glycol dinitrate; Matrix: water (propylene glycol dinitrate stock solutions); Detection Level: 0.5 mg/L. /From table/|For more Analytic Laboratory Methods (Complete) data for 1,2-PROPANEDIOL DINITRATE (6 total), please visit the HSDB record page.

Method: Mass Spectrometry; Analyte: propylene glycol dinitrate; Matrix: breath and blood gas; Detection Level: less than 1 mg/cu m breath; 1 ug/mL blood. /From table/|Method: Spectrophotometry; Analyte: propylene glycol dinitrate; Matrix: blood and urine; Detection Level: 0.2 ug/mL blood. /From table/|Method: Gas Chromatography/Electron Capture Detection; Analyte: propylene glycol dinitrate; Matrix: blood and urine; Detection Level: 10 nanogram/mL. /From table/