Isobutylamine

73.14

73.14

385626

201-145-4

1H60H4LOHZ

1253

8028

1214

DTXSID9025459

Colorless liquid

29211990

26

0.73

Clear colorless to slightly yellow Liquid

0.724 g/cm³ @ Temp: 25 °C

-85 °C

68-69 °C

15 °F

n20/D 1.397(lit.)

H2O: soluble

Store below +30°C.

Vapour pressure, kPa at 18.8°C: 13.3

Relative vapour density (air = 1): 2.5

Oral-Rat LD50: 224 mg/kg

Inflammable in case of open flame, high temperature, oxidant; burning produces toxic nitrogen oxide fumes

2-9%(V)

Amine odor

Henry's Law constant = 1.4X10-5 atm-cu m/mole at 25 °C (est)

pKa = 10.68 at 25 °C (conjugate acid)

CONVERSION UNITS: 1 MG/L= 334 PPM; 1 PPM= 2.99 MG/CU M|It is lighter than water. ... Its vapors are heavier than air. ... It weighs 6.1 lb/gal.|Hydroxyl radical reaction rate constant = 3.4X10-11 cu cm/molecule-sec at 25 °C (est)

Highly flammable. Soluble in water.

Amines, Phosphines, and Pyridines

Highly Flammable

ISOBUTYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

712 °F (USCG, 1999)|712 °F (378 °C)|378 °C

-3013.5 kJ/mol at 25 °C (liquid); -3047.4 kJ/mol at 25 °C (gas)

Lower 3.4%; upper 9%

The vapour is heavier than air and may travel along the ground; distant ignition possible.

Strongly caustic

33.85 kJ/mol at 25 °C

Critical temperature: 519 K; Critical pressure: 4.07 MPa

II

3

UN 1214 3/PG 2

1

11-22-35

26-36/37/39-45

NP9900000

F,C

The warehouse is ventilated, low temperature and dry; stored separately from oxidants and acids

Stable during shipment.

P210-P280-P301 + P310-P305 + P351 + P338-P310

H225-H301-H314

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|Incineration; Incinerator is equipped with a scrubber or thermal unit to reduce NOx emissions. Alternatively it may be poured into sodium bisulfate, neutralized and flushed with water. /n-Butylamine/|Burn the paper in a suitable location away from combustible material. Large quantities can be reclaimed or collected and atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device. /N-butylamine/|/Absorb small spills with paper and/ burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device.

Forms explosive mixture with air. May accumulate static electrical charges, and may cause ignition of its vapors. n-Butylamine is a weak base; reacts with strong oxidizers and acids causing fire and explosion hazard. Incompatible with organic anhydrides, isocyanates, vinyl acetate, acrylates, substituted allyls, alkylene oxides, epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. Attacks some metals in presence of moitsure. /Butyl Amines/|Reacts with oxidizers.

Special Hazards of Combustion Products: Toxic oxides of nitrogen may be formed in fire. Behavior in Fire: Vapor is heavier than air and may travel to a source of ignition and flash back. Containers may explode. (USCG, 1999)|Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive.|Flammable - 3rd degree

|Danger|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P310, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P311, P312, P321, P322, P330, P361, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 265 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P310, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Fully encapsulating, vapor-protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material and transfer to containers (except for Hydrazine). Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Self-contained breathing apparatus; butyl rubber gloves; chemical face shield; butyl rubber apron (USCG, 1999)|Closed system, ventilation, explosion-proof electrical equipment and lighting. Use non-sparking handtools.|Face shield or eye protection in combination with breathing protection.|Wear protective gloves and clothing to prevent any reasonable probability of skin contact. Teflon is recommended by safety equipment suppliers/manufacturers for n-Butylamine and Chlorinated polyethylene (CPE) and VITON/chlorobutylene for Isobutylamine. Contact lenses should not be worn when working with this chemical. Wear dust-proof chemical goggles and face shield unless full face-piece respiratory protection is worn. Employees should wash immediately with soap when skin is wet or contaminated. Provide emergency showers and eyewash. /Butyl Amines/|Personal Protection: ... Wear appropriate chemical protective gloves, boots and goggles ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.

Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire.|DANGEROUS, WHEN EXPOSED TO HEAT OR FLAME; CAN REACT VIGOROUSLY WITH OXIDIZING MATERIALS

Vapor/air mixtures are explosive.|3.4% Lower, 9% Upper|Explosive limits , vol% in air: 3.4-9

Dry chemical, foam, carbon dioxide, or alcohol foam.|If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking liquid in sealable containers. Cautiously neutralize spilled liquid. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Then wash away with plenty of water.|Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable. /Butyl Amines/|Small Spill: Use absorbent paper to pick up spilled material. Follow by washing surfaces well with soap and water. Seal all wastes in vapor-tight plastic bags for eventual disposal.|Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. Apply appropriate foam to diminish vapor and fire hazard. Neutralize with sodium bisulfate (NaHSO4).|For more Cleanup Methods (Complete) data for ISOBUTYLAMINE (6 total), please visit the HSDB record page.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.|Do not eat, drink, or smoke during work.|Keep away from heat and open flame.|If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to disperse vapors and dilute standing pools of liquid.|For more Preventive Measures (Complete) data for ISOBUTYLAMINE (6 total), please visit the HSDB record page.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.|For more DOT Emergency Guidelines (Complete) data for ISOBUTYLAMINE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

A POWERFUL IRRITANT TO SKIN, EYES, & MUCOUS MEMBRANE.

Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Cautiously neutralize spilled liquid. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Wash away remainder with plenty of water.

Fireproof. Separated from strong oxidants, strong acids and food and feedstuffs.

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. The effects may be delayed. Medical observation is indicated.

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Use non-sparking handtools.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Isobutylamine was detected in the leachate from a municipal refuse waste disposal site in the Netherlands at a concn of 32 ppm(1). Isobutylamine was identified, not quantified, in the effluent of a cattle feed lot(2).

Isobutylamine was identified, not quantified, as a constituent of soil from Moscow, USSR(1).

Isobutylamine was qualitatively detected in tobacco smoke(1). It was detected at a concn of 1.06 ppm in a commercial fermented egg product (FEP) used to attract coyotes(2).

highly toxic

LD50 Rat oral 228 mg/kg

... amines from decomposing fish ... /Amines/|/The microbe/ ... Proteus mirabilis was found to produce isobutylamine.|Isobutylamine is a natural component of tobacco(1) and has been detected in marine algae(2).

Isobutylamine's production and use as a chemical intermediate in the synthesis of insecticides(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 60(SRC), determined from a log Kow of 0.73(2) and a regression-derived equation(3), indicates that isobutylamine is expected to have high mobility in soil(SRC). The pKa of isobutylamine is 10.68(4) indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of isobutylamine from moist soil surfaces is not expected to be an important fate process given its cation state(SRC). Isobutylamine is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(6). Isobutylamine was 87 percent and 68 percent biodegraded during a 2 week incubation period using a Japanese MITI test(7), suggesting that biodegradation may occur in soils(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 60(SRC), determined from a log Kow of 0.73(2) and a regression-derived equation(3), indicates that isobutylamine is not expected to adsorb to suspended solids and sediment in water(SRC). A pKa of 10.68(4) indicates isobutylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Isobutylamine was 87 percent and 68 percent biodegraded during a 2 week incubation period using a Japanese MITI test(8), suggesting that biodegradation may occur in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), isobutylamine, which has a vapor pressure of 138 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase isobutylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 11 hours(SRC) from its estimated rate constant of 3.4X10-11 cu cm/molecule-sec at 25 °C(SRC), derived using a structure estimation method(3). Isobutylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of isobutylamine with photochemically-produced hydroxyl radicals has been estimated as 3.4X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 11 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Isobutylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Isobutylamine does not contain chromophores that absorb at wavelengths >290 nm(2) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated for isobutylamine(SRC), using a log Kow of 0.73(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of isobutylamine is estimated as 60(SRC), using a log Kow of 0.73(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that isobutylamine is expected to have high mobility in soil. The pKa of isobutylamine is 10.68(4) indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

A pKa of 10.68(1) indicates isobutylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(2). The potential for volatilization of isobutylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 138 mm Hg(3).

Volatile amines /including isobutylamine were/ isolated ... from 4 month old Chanakh cheese.|The concn of various amines in 13 red and 10 white Italian wines were determined. ... The mean value for the red and white wines were 0.06 mg/L and 0.23 mg/L for isobutylamine, respectively.|Isobutylamine has been qualitatively detected in various Italian cheeses, in German wine, in American beef, in Valencia oranges, lemons from CA and cooked and boiled beef(1-6).|Isobutylamine concentrations in various foods(1). [Table#1717]

... The presence of volatile aliphatic amines ... in human breast milk and amniotic fluid /was measured/ to assess their role in neonatal hypergastrinemia. These volatile nitrogenous amino acid metabolites have been previously demonstrated to stimulate gastrin release in in vivo and in vitro laboratory preparations. ... The present study ... demonstrated that these gastrin-stimulatory volatile amines were present in significant concentrations in breast milk during the first several weeks after parturition and in amniotic fluid. The individual amines that were identified in both human milk and amniotic fluid samples were methylamine, dimethylamine, ethylamine, trimethylamine, propylamine, isobutylamine, and butylamine. This study provides indirect evidence to support the possibility that the hypergastrinemia measured in the fetus/neonate during the period immediately before and after birth may be attributable, in part, to the ingestion of fluid containing high concentrations of gastrin-stimulating amines.

Occupational exposure to isobutylamine may occur through inhalation and dermal contact with this compound at workplaces where isobutylamine is produced or used. Monitoring data indicate that the general population may be exposed to isobutylamine through the ingestion of food and the use of tobacco products. (SRC)

Inhalation causes severe coughing and chest pain due to irritation of air passages; can cause lung edema. Compound is sympathomimetic and is also a cardiac depressant and convulsant; ingestion causes nausea and profuse salivation. Contact with eyes causes severe irritation and edema of the cornea. Contact with skin causes severe irritation. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting. Thus, the risk of increasing the medical problems by inducing vomiting of a volatile corrosive chemical is very high. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/|First Aid: Inhalation - Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. Skin Contact - Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention. Eyes - First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. Ingestion - Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention.

/SIGNS AND SYMPTOMS/ INHALATION: Burning sensation. Cough. Shortness of breath. Labored breathing. Symptoms may be delayed. SKIN: Pain. Redness. EYES: Redness. Pain. Severe deep burns. Skin burns. INGESTION: Abdominal pain. Burning sensation. Shock or collapse.|/SIGNS AND SYMPTOMS/ SKIN CONTACT CAN RESULT IN ERYTHEMA, BLISTERING. INHALATION CAUSES HEADACHE, DRYNESS OF NOSE & THROAT.|/SIGNS AND SYMPTOMS/ Isobutylamine induces nausea and unpleasant salivation in man at 40 mg/kg orally.|/SIGNS AND SYMPTOMS/ Skin contact can result in erythema and blistering; inhalation causes headache and dryness of the nose and throat.|For more Human Toxicity Excerpts (Complete) data for ISOBUTYLAMINE (8 total), please visit the HSDB record page.

isobutylamine

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Burning sensation. Cough. Shortness of breath. Laboured breathing. Symptoms may be delayed.

Pain. Redness. Skin burns.

Redness. Pain. Severe deep burns.

VALAMINE

1-Propanamine, 2-methyl-: ACTIVE|With isobutylamine, crotonic acid forms interpolymerization products suitable for sizing and wood sealing.|Aziridines are hydrogenated in the presence of typical hydrogenation catalysts to give alkyl amines.

A MIXT OF 13 LOWER ALIPHATIC AMINES INCLUDING ISOBUTYLAMINE WERE SEPARATED IN A TENAX-GC COLUMN BY TEMP PROGRAMMING GAS CHROMATOGRAPHY.|CYCLIC AMINES, KETONES & ALCOHOLS WERE EXTRACTED FROM URINE SAMPLES WITH DICHLOROMETHANE & SEPARATED BY GAS CHROMATOGRAPHY. ISOBUTYLAMINE COULD ALSO BE SEPARATED BY GAS CHROMATOGRAPHY BUT NOT EXTRACTED FROM URINE.|METHODS ARE GIVEN FOR THE SEPARATION AND DETERMINATION OF AMINO ACIDS, DIPEPTIDES AND AMINES BY ION-PAIR HIGH PERFORMANCE LIQUID CHROMATOGRAPHY. /AMINES/|THE VOLATILE AMINE CONTENT IN TOMATOES AND TOMATO PRODUCTS IS ESTIMATED BY GAS CHROMATOGRAPHY/MASS SPECTROMETRY. /AMINES/|For more Analytic Laboratory Methods (Complete) data for ISOBUTYLAMINE (6 total), please visit the HSDB record page.

Food additives -> Flavoring Agents|Flavoring Agents -> JECFA Flavorings Index|Fire Hazards -> Flammable - 3rd degree

Flavoring Agents