Isobutyraldehyde

72.11

72.11

605330

201-149-6

C42E28168L

0902

6739

2045

DTXSID9021635

Transparent, colorless liquid

2912190090

17.1

1.2

Clear Liquid

0.7938 g/cm³ @ Temp: 20 °C

-65.9 °C

64 °C @ Press: 760 Torr

−40 °F

1.367

H2O: 75 g/L (20 ºC)

2-8°C

66 mm Hg ( 4.4 °C)

2.5 (vs air)

Oral-rat LD50: 960mg/kg; inhalation-mouse LC50: 39500mg/m3/2 hours

Inflammable in case of open flame, high temperature, oxidant; burning produces irritating smoke

1.6-11.0%(V)

EXTREMELY SHARP

FRUITY TASTE

2.63e-11 cm3/molecule*sec

LIQ-WATER INTERFACIAL TENSION: 7.2 DYNES/CM= 0.0072 N/M @ 22.7 °C; RATIO OF SPECIFIC HEATS OF VAPOR (GAS): 1.093|CONVERSION FACTORS: 1 MG/L IS EQUIV TO 340 PPM; 1 PPM IS EQUIV TO 2.9 MG/CU M|Hydroxyl radical reaction rate constant = 2.63X10-11 cu-cm/molc sec @ 25 °C

Highly flammable. Oxidizes slowly on exposure to air. Stable (less than 10% decomposition) for four hours when exposed to light and air in a closed system. Stable for two weeks when stored under nitrogen at temperatures up to 77°F. Insoluble in water.

Aldehydes

Highly Flammable

ISOBUTYL ALDEHYDE can react vigorously with reducing agents, with oxidizing agents, strong bases and mineral acids. Can undergo exothermic self-condensation or polymerization reactions that are often catalyzed by acid. Generates flammable and/or toxic gases in combination with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. Reacts slowly when exposed to air with air to give peroxides and other products. These reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by their products). The addition of stabilizers (antioxidants) retards autoxidation.

Isobutyraldehyde|B*: Compounds that form peroxides on concentration (distillation/evaporation)|1 sample, 2 ppm, > 1 yr|Bretherick's|https://cameochemicals.noaa.gov/chemical/8366

385 °F (USCG, 1999)|385 °F (196 °C)|165 °C

599.9 kcal

% BY VOL; LOWER 1.6, UPPER 10.6

The vapour is heavier than air and may travel along the ground; distant ignition possible.

180 BTU/LB= 98 CAL/G= 4.1X10+5 JOULE/KG

CRITICAL TEMP: 464 °F= 240 °C= 513 DEG K; CRITICAL PRESSURE: 600 PSIA= 41 ATM= 4.2 MN/SQ M

II

3

UN 2045 3/PG 2

1

11-22-36

16-36/37-9-33-29-26

NQ4025000

F,Xn,Xi

The warehouse is ventilated, low temperature and dry; stored separately from oxidants and acids

Explosive when mixed with air

Stable. Refrigerate. Highly flammable. Incompatible with strong oxidizing agents, strong bases, strong acids, strong reducing agents.

P210-P305 + P351 + P338

H225-H319

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|(1) Absorb on vermiculite and burn in open incinerator. (2) Dissolve in flammable solvent and spray in incinerator with after burner.

CAN REACT VIGOROUSLY WITH REDUCING MATERIALS.

Isobutyraldehyde is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and 2) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.

Toxicology & Carcinogenesis Studies of Isobutyraldehyde in F344/N Rats and B6C3F1 Mice. Technical Report Series No. 472 (1999) NIH Publication No. 99-3962 U.S. Department of Health and Human Services, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709

Behavior in Fire: Vapors are heavier than air and may travel considerable distance to a source of ignition and flash back. Fires are difficult to control due to ease of reignition. (USCG, 1999)|Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive.|Flammable - 3rd degree, Reactive - 1st degree

|Danger|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P264, P280, P303+P361+P353, P305+P351+P338, P337+P313, P370+P378, P403+P235, and P501|Aggregated GHS information provided by 4083 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P281, P301+P312, P303+P361+P353, P304+P340, P308+P313, P312, P330, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Appropriate protective clothing, including rubber gloves, rubber shoes and protective eyewear. (USCG, 1999)|Appropriate protective clothing, including rubber gloves, rubber shoes, and protective eyewear. Vapors cause moderate irritation such that personnel will find high concn unpleasant. Effect is temporary.

A very dangerous fire hazard when exposed to heat, flame, or oxidizers.

EXPLOSIVE LIMITS: UPPER 10.6%; LOWER 1.6%|EXPLOSION HAZARD: MODERATE, IN THE FORM OF VAPOR WHEN EXPOSED TO HEAT OR FLAME.|Explosive limits , vol% in air: 1.6-10.6

Foam, dry chemical or carbon dioxide.|WEAR GOGGLES & SELF-CONTAINED BREATHING APPARATUS. ... COOL EXPOSED CONTAINERS WITH WATER.

VAPORS ARE HEAVIER THAN AIR & MAY TRAVEL CONSIDERABLE DISTANCE TO SOURCE OF IGNITION & FLASH BACK. FIRES ARE DIFFICULT TO CONTROL DUE TO EASE OF REIGNITION.

PRECAUTIONS FOR HIGHER ALDEHYDES ... SHOULD INCL ADEQUATE VENTILATION IN AREAS WHERE HIGH EXPOSURES ARE EXPECTED, FIRE & EXPLOSION PRECAUTIONS, & PROPER INSTRUCTION OF EMPLOYEES IN USE OF RESPIRATORY, EYE, & SKIN PROTECTION. /HIGHER ALIPHATIC ALDEHYDES/|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for ISOBUTYRALDEHYDE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Irritant to skin and eyes.

Evacuate danger area! Consult an expert! Remove all ignition sources. Personal protection: protective clothing, protective gloves, safety goggles and filter respirator for organic vapours of low boiling point adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Collect leaking liquid in sealable containers. Cover the spilled material with inert absorbent. Then store and dispose of according to local regulations.

Fireproof. Separated from strong oxidants, strong bases, strong acids and strong reducing agents. Well closed. Store in an area without drain or sewer access.

No indication can be given whether a harmful concentration in the air will be reached.

The substance is irritating to the eyes. The substance at very high concentrations is irritating to the upper respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. Medical observation is indicated. The substance may cause effects on nervous system. Exposure could cause lowering of consciousness.

Repeated or chronic inhalation of the vapour may cause chronic inflammation of the upper respiratory tract.

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.

PREVENT GENERATION OF MISTS!

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety spectacles.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Isobutyraldehyde is produced, as an intermediate or a final product, by process units covered under this subpart.

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 1 - Materials that in themselves are normally stable but that can become unstable at elevated temperatures and pressures.

Isobutyraldehyde emission factors ranging from 2.6 to 79.5 mg/kg were detected in the flue gas of cookstoves(1). Isobutyraldehyde's emission rate from hamburger meat charbroiling over a natural gas fired grill was measured and found to be 373,000 ug/kg(2).|An isobutyraldehyde concn of 0.13 ppm was detected in an automobile exhaust sample(1); isobutyraldehyde was qualitatively detected in wood smoke emissions(1). Isobutyraldehyde has been detected in volatile emissions from Northern white cedar trees(2). Monitoring of automobile exhaust from four vehicles equipped in low nitrogen oxide catalytic converters, detected mean isobutyraldehyde emission rates of 0.14-1.57 mg/km(3).

Isobutyraldehyde was qualitatively detected in vapor-phase ambient air samples collected in the Kanawha Valley, WV in Sept 1977(1).

Isobutyraldehyde is reported to occur in tobacco smoke(1).

moderately toxic

LD50 Rat oral 3.7 g/kg|LD50 Rat oral 2810 mg/kg|LC50 Mouse inhalation 39,500 mg/cu m/2 hr|LD50 Rabbit skin 7130 mg/kg

... Groups of 50 male and 50 female F344/N rats were exposed to 0, 500, 1,000 or 2,000 ppm isobutyraldehyde by inhalation 6 hr/day, 5 days/wk for 105 wk. Groups of 50 male and female B6C3F1 mice were exposed to 0, 500, 1,000 or 2,000 ppm isobutyraldehyde by inhalation, 6 hr/day, 5 days/wk for 105 wk. CONCLUSIONS: Under the conditions of these 2 yr inhalation studies, there was no evidence of carcinogenic activity of isobutyraldehyde in male or female F344/N rats or male or female B6C3F1 mice exposed to 500, 1,000 ppm or 2,000 ppm.

REPORTED FOUND IN APPLE & CURRANT AROMAS & IN ESSENTIAL OILS FROM TOBACCO LEAVES & TEA LEAVES; ALSO IN THE ESSENTIAL OILS OF: PINUS JEFFREYI MURR LEAVES, CITRUS AURANTIUM LEAVES, & DATURA STRAMONIUM.|Similar to other saturated aldehydes, isobutyraldehyde occurs naturally in foods(1); it is also emitted into the atmosphere by plants(1).

Isobutyraldehyde's production and use in the synthesis of cellulose esters, perfumes, flavors, gasoline additives(1), and amino acids(2), and as an intermediate for rubber antioxidants and accelerators(2) may result in its release to the environment through various waste streams(SRC). Isobutyraldehyde is also emitted into the atmosphere by combustion sources(3).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 8(SRC), determined from a water solubility of 8.9X10+4(2) and a regression-derived equation(3), indicates that isobutyraldehyde is expected to have very high mobility in soil(SRC). Volatilization of isobutyraldehyde from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.8X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 173 mm Hg(4), and its water solubility(2). The potential for volatilization of isobutyraldehyde from dry soil surfaces may exist(SRC) based upon a its vapor pressure(4). Biodegradation is expected to be the major environmental fate process for isobutyraldehyde in soil since it was found to readily biodegrade in water(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 8(SRC), determined from a water solubility of 8.9X10+4(2) and a regression-derived equation(3), indicates that isobutyraldehyde is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.8X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 173 mm Hg(4), and its water solubility(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 3.6 hrs and 4.6 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 1(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Isobutyraldehyde, present at 100 mg/l, reached 81% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(6).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), isobutyraldehyde, which has a vapor pressure of 173 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase isobutyraldehyde is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 14.6 hours(SRC), calculated from its rate constant of 2.6X10-11 cu cm/molecule-sec at 25 °C(3). Based upon direct photolysis measurements, the direct photolysis rate constants of isobutyraldehyde at solar zenith angles of 30 and 58 deg were determined to be 7.6X10-5 and 5.9X10-5 /sec(4), respectively, which correspond to respective half-lives of 2.5 and 3.3 hr(SRC).

The rate constant for the vapor-phase reaction of isobutyraldehyde with photochemically-produced hydroxyl radicals has been estimated as 2.6X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 14.6 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Isobutyraldehyde is not expected to chemically hydrolyze in the environment due to the lack of hydrolyzable functional groups(2). Based upon direct photolysis measurements, the direct photolysis rate constants of isobutyraldehyde at solar zenith angles of 30 and 58 deg were determined to be 7.6X10-5 and 5.9X10-5 /sec(3), respectively, which correspond to respective half-lives of 2.5 and 3.3 hr(SRC). Carbon monoxide is one of the products formed from atmospheric photolysis and OH reaction with isobutyraldehyde(4).

An estimated BCF of 1 was calculated for isobutyraldehyde(SRC), using a water solubility of 89,000 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of isobutyraldehyde is estimated as 8(SRC), using a water solubility of 8.9X10+4(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that isobutyraldehyde is expected to have very high mobility in soil(SRC).

The Henry's Law constant for isobutyraldehyde is estimated as 1.8X10-4 atm-cu m/mole(SRC) based upon its vapor pressure, 173 mm Hg(1), and water solubility, 8.9X10+4 mg/l(2). This Henry's Law constant indicates that isobutyraldehyde is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 3.6 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 4.6 days(SRC). Isobutyraldehyde's estimated Henry's Law constant(1,2) indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of isobutyraldehyde from dry soil surfaces may exist(SRC) based upon a vapor pressure of 173 mm Hg(1).

DRINKING WATER: As part of the USEPA's National Organics Reconnaissance Survey (NORS) which was initiated in 1974, isobutyraldehyde was detected (concns not reported) in 7 drinking waters from 10 cities(1); five of the cities were Miami, FL, Ottumwa, IA, Philadelphia, PA, and Cincinnati, OH(2). Drinking water samples collected from Edmonton, Alberta Canada in 1986 contained isobutyraldehyde concns of 54 ppb(3); the source of the isobutryaldehyde in the water was suggested to result from the oxidation of naturally-occurring amino acids during chlorination treatment(3).|SURFACE WATER: Isobutyraldehyde was detected in 1 of 204 samples collected from 14 heavily industrialized river basins in the US between Aug 1975 and Sept 1976(1); the single positive detection was at a concn of 1 ppb(1). Isobutyraldehyde has been detected in the aquatic ecosystem of the Niagara River/Lake Ontario(2); concns, sampling dates, and sample types (water, whole water or sediment) were not reported(SRC).

Isobutyraldehyde has been qualitatively detected as a volatile constituent of coffee(1), fried bacon(2), roasted filbert nuts(3), cooked meats(4), and chickpeas(5). Isobutyraldehyde concns of 27-140 ppb were detected in dried samples of lima beans, common beans, mung beans, soybeans, split peas, and lentils(6). Isobutyraldehyde has been qualitatively detected in peanut butter(7), cheddar cheese(8), and bread(9). Isobutyraldehyde was qualitatively detected in whole and ground grain samples(10).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 4,114 workers (655 of these are female) are potentially exposed to isobutyraldehyde in the US(1). Occupational exposure to isobutyraldehyde may occur through inhalation and dermal contact with this compound at workplaces where isobutyraldehyde is produced or used(SRC). Monitoring data indicate that the general population may be exposed to isobutyraldehyde through consumption of food (since it occurs naturally in many foods) and consumption of drinking water(SRC).

Isobutyraldehyde has been detected in human urine and feces(1).

Vapor is irritating to the eyes and mucous membranes. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting. Thus, the risk of increasing the medical problems by inducing vomiting of a volatile corrosive chemical is very high. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fresh air, rest. Refer for medical attention.

Rinse skin with plenty of water or shower. Remove contaminated clothes. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Aggressive airway management may be necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . Monitor for pulmonary edema and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aldehydes and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Intubation should be considered at the first sign of upper airway obstruction caused by edema. Positive pressure ventilation techniques with a bag-valve-mask device may be beneficial. Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Treat seizures with diazepam ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Consider drug therapy for pulmonary edema ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Aldehydes and related compounds/

IF SPILLED ON CLOTHING & ALLOWED TO REMAIN, MAY CAUSE SMARTING & REDDENING OF SKIN.|As inferred from inhalation studies ingestion of ... isobutyraldehyde may produce /CNS/ depression with symptoms like alcohol intoxication.

2-methylpropanal

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Sore throat. Cough. Burning sensation. Headache. Dizziness. Nausea. Vomiting.

Redness.

Pain. Redness.

5.37X10+10 G AS A CHEM INT FOR ISOBUTYL ALCOHOL (1974 EST)

GRADES OR PURITY: DRY GRADE: 98.0%; WET GRADE: 96.0%; COMMERCIAL 97%.

All other basic organic chemical manufacturing|Propanal, 2-methyl-: ACTIVE|FEMA NUMBER 2220|ISOBUTYRALDEHYDE & ITS COGENERS OCCUR IN A WIDE VARIETY OF FEEDSTUFFS, WHERE THEY MAY SERVE AS INDICATORS FOR THE AVAILABILITY OF THE INDISPENSABLE AMINO ACIDS VALINE, LEUCINE, & ISOLEUCINE.

ISOBUTYRALDEHYDE WAS IDENTIFIED IN CIGARET SMOKE BY GAS CHROMATOGRAPHY USING THE IMINE FORMATION REACTION.|NIOSH Method 2539. Analyte: Isobutyraldehyde. Matrix: Air. Procedure: Gas chromatography, flame ionization detector and gas chromatography/mass spectrometry. For isobutyraldehyde this method has an estimated detection limit of 2 ug aldehyde/sample. The precision/RSD and the recovery are not determined. Applicability: This is a screening technique to determine the presence of aldehydes and should not be used for quantitation. Interferences: High boiling naphtha mixtures, such as kerosene and mineral spints may have components with retention times similar to the oxazolidines and may be interferences in the gas chromatographic analysis.|Analysis of the volatile constituents of food by headspace gas chromatography/mass spectrometry with reversal of the carrier gas flow during sampling.|The use of headspace gas chromatography fourier-transfrom-infrared spectrometry for the monitoring of volatiles in commercial brand coffees.|For more Analytic Laboratory Methods (Complete) data for ISOBUTYRALDEHYDE (6 total), please visit the HSDB record page.

HEAD-SPACE GAS CHROMATOGRAPHY WAS CARRIED OUT ON BLOOD SAMPLES & URINE SAMPLES. A SIGMA 10 DATA SYSTEM WAS USED FOR AUTOMATIC EVALUATION OF ETHANOL CONGENERS IN HARD DRINKS. ISOBUTYRALDEHYDE WAS DETECTED.

Food additives -> Flavoring Agents|Flavoring Agents -> JECFA Flavorings Index|Fire Hazards -> Flammable - 3rd degree, Reactive - 1st degree

Flavoring Agents