Thiosemicarbazide

91.13550

91.14

201-184-7

6056O8W6ET

31792|2213

2811|2771

DTXSID9021346

White crystalline powder|Long needles from water

2942000000

96.16000

0.48480

THIOSEMICARBAZIDE is a white crystalline powder and is odorless. This material is used as a reagent for ketones and certain metals, for photography and as a rodenticide. It is also effective for control of bacterial leaf blight of rice. Not a registered pesticide in the U.S. It is a chemical intermediate for herbicides and a reagent for detection of metals. (EPA, 1998)

1.376 g/cm3

183 °C

208.6ºC at 760 mmHg

80ºC

1.463 (20ºC)

H2O: soluble ;Very soluble in ethanol

Poison room

0.0087 mm Hg at 25 deg C (est)

LD50 orally in adult Norway rats: 13 mg/kg, Dieke, Proc. Soc. Exp. Biol. Med. 70, 688 (1949)

Odorless

Henry's Law constant = 6.6X10-10 atm-cu m/mol at 25 °C (est)

pKa1 = 3.86(+); pKa2 = 14.51(-) (est)

Hydroxyl radical reaction rate constant = 8.4X10-11 cu cm/molec-sec at 25 °C (est)

No rapid reaction with air. No rapid reaction with water.

Azo, Diazo, Azido, Hydrazine, and Azide Compounds

Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].

II

6.1

UN 2811

3

R28; R52/53

S28-S45-S61

VT4200000

T+

Stable. Incompatible with strong oxidizing agents.

P264-P301 + P310

H300

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P116, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.|A potential candidate for rotary kiln incineration at a temperature range of 820 to 1600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.|Waste treatment methods. Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging: Dispose of as unused product.

Incompatible materials: Strong oxidizing agents, strong acids, strong bases.

Bazhina lM, kudymov GI; Farmatsiya (Moscow) 29 (3): 68-70 (1980). A review with 14 references on thiourea & thiosemicarbazide determination in drugs.

When heated to decomposition, very toxic fumes of sulfur oxides and nitrogen oxides are emitted. (EPA, 1998)

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 81 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H300: Fatal if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Avoid skin contact, ingestion or inhalation. (Non-Specific -- Poisonous Solid, n.o.s.) Do not touch spilled material; stop leak if you can do it without risk. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal. (EPA, 1998)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)|Wear rubber gloves & gas mask. /Thiourea/|Eye/face protection: Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).|Skin protection: Handle with gloves.|Body Protection: Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.|Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Special hazards arising from the substance or mixture: Carbon oxides, nitrogen oxides (NOx), sulphur oxides.

Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.|Appropriate engineering controls: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.|Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

P116; An acute hazardous waste when a discarded commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate.

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Thiosemicarbazide is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100 or 10,000 lbs. Extremely hazardous substances that are solids are subject to either of two threshold planning quantities ... The lower quantity applies only if the solid exists in powdered form and has a particle size less than 100 microns; or is handled in solution or in molten form; or meets the criteria for a National Fire Protection Association (NFPA) rating of 2, 3 or 4 for reactivity. If the solid does not meet any of these criteria, it is subject to the upper ... threshold planning quantity ... .|Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

P116; As stipulated in 40 CFR 261.33, when hydrazinecarbothioamide, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to federal and/or state hazardous waste regulations. Also defined as a hazardous waste is any container or inner liner used to hold this waste or any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5(e)).

IDENTIFICATION AND USE: 1-Amino-2-thiourea is an odorless white crystalline powder or long needles from water. It is an intermediate for pesticides, especially herbicides, and pharmaceuticals; used in certain photographic and dye applications and used as a reagent for the detection of metals. HUMAN EXPOSURE AND TOXICITY: Thioureas are potential sensitizing accelerators and antioxidants used in the manufacture of rubber which may cause irritant contact dermatitis. ANIMAL STUDIES: Subcutaneous injections of thiosemicarbazide into postnatal mice caused convulsions in mice when treated on the day 7 or later but not on the days 1-5. The latent period of the 1st convulsion was 115 min in mice injected on the day 7. The convulsions were inhibited by pyridoxine-HCL, but not by pyridoxal phosphate. GABAergic antagonists (1-amino-2-thiourea) enhanced aggressive behavior and decreased the social behavior of mice. 1-amino-2-thiourea was noncarcinogenic in mice and rats. The agent was teratogenic in chick embryos when applied to the vascular area on the 3rd day of incubation at 0.5 to 1 mg it produced deformities of the wing and beak, but not harelip. ECOTOXICITY STUDIES: Exposure of Rana sylvatica tadpoles to 25 mg/L or more caused a curvature of digits, abnormal limb articulations, difficulty in swimming, and death. Wood frog (Rana sylvatica) tadpoles were exposed to 50 mg thiosemicarbazide (TSC)/L water for varying lengths of time and at different developmental stages. Short exposure periods (3 and 6 hr) resulted in no visible deformities. Exposure periods of 12 or more hr caused slight to severe abnormalities, with a direct relationship between length of exposure and degree of deformity. Tadpoles exposed to TSC from posthatching Days 24-30 were more seriously affected than were tadpoles exposed at an older age.

The acute neurobehavioral toxicity of organochlorine pesticide, aldrin, has been studied at sublethal doses. A dose of 8.9 mg/kg (1/4 LD50) induced piloerection, tremors, convulsive excitement restlessness, augmented spontaneous motor activity and exploratory behavior in mice after 60 min, of i.p. administration indicating CNS stimulation. Blockade of specific neurotransmitter system by pretreatment with atropine (10 mg/kg), iproniazid (100 mg/kg) alpha-methyl-p-tyrosine (200 mg/kg), p-chlorophenylalanine (200 mg/kg) or thiosemicarbazide (5 mg/kg) significantly altered the neurotoxic symptoms induced by the pesticide indicating direct or indirect involvement of various neurotransmitter system in mediating CNS toxicity. Conditioned avoidance response in rats was not affected by the pesticide alone or in combination with either drug.|Female CD1 mice given the contraceptive steroids mestranol and norethynodrel (1:10) in the diet (0.0033%) for 4 months had a growth reduction of 20% when compared with mice fed a normal diet, and had lower convulsive thresholds when tested with the vitamin B6 antagonists 2,4-dimethyl-5-methyl-hydroxypyrimidine and thiosemicarbazide. In conditioned avoidance response (CAR) tests, mice fed the steroid-containing diets showed a decreased acquisition performance during all six sessions; however, mice fed the same diet supplemented with vitamin B6 (0.04%) performed as well during the last three sessions of the CAR tests as mice fed the normal diet.|Susceptibility to thiosemicarbazide was compared in 7 animal species together with the protective effect of vitamin B6 on the induction of convulsions. Susceptibility occurred generally with the phylogenetic development of the brain of vertebrates as well as invertebrates. Abnormal behavior analogous to running fits in rats and mice, which was thought to be a characteristic and activated form of locomotion, was also induced in every animal except the silkworm. Vitamin B6 arrested the induction of convulsions and abnormal behavior in guinea pigs and goldfish.|GABA-/inhibitory/ agents (thiosemicarbazide) markedly decreased the effect of morphine, hydrocodone, and the enkephaline analogs: Tyr-D-Ala-Gly-Phe-NH2 and Tyr-D-Ala-Gly-Phe (NO2) NH2 /in experimental animals/.|For more Interactions (Complete) data for 1-AMINO-2-THIOUREA (15 total), please visit the HSDB record page.

LD50 Norway Rat adult oral 13 mg/kg|LD50 Rat oral 9160 ug/kg|LD50 Mouse ip 1 mg/kg|LD50 Mouse sc 16,407 ug/kg|For more Non-Human Toxicity Values (Complete) data for 1-AMINO-2-THIOUREA (8 total), please visit the HSDB record page.

/AQUATIC SPECIES/ The effects of exposure of Rana sylvatica tadpoles to varying concentrations (10-75 mg/L for 4 days) of thiosemicarbazide (TSC) was studied. Exposure to concentrations of 25 mg/L or more caused a curvature of digits, abnormal limb articulations, difficulty in swimming, and death. For all of these parameters, effects were dose dependent. Tadpoles exposed to 10 mg/L metamorphosed significantly slower than controls while those exposed to 50 mg/L metamorphosed significantly faster than controls. Rate of endochondral ossification in femurs and tibio-fibulas also was affected by TSC. These long bones ossified faster than in controls in both the 25- and 75-mg/L exposure groups. R. sylvatica tadpoles respond to TSC (a known osteolathyrogen) in a manner similar to that of other species. This response appears to be due in part to an acceleration of long bone ossification and speed of metamorphosis in high-concentration exposure groups. These responses are similar but not identical to those seen in Xenopus laevis, the only other amphibian studied to date.|/AQUATIC SPECIES/ Wood frog (Rana sylvatica) tadpoles were exposed to 50 mg thiosemicarbazide (TSC)/L water for varying lengths of time and at different developmental stages. Short exposure periods (3 and 6 hr) resulted in no visible deformities. Exposure periods of 12 or more hr caused slight to severe abnormalities, with a direct relationship between length of exposure and degree of deformity. Tadpoles exposed to TSC from posthatching Days 24-30 were more seriously affected than were tadpoles exposed at an older age.

1-Amino-2-thiourea's production and use as a reagent for ketones and certain metals, in photography, and in the production of pesticides(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 16(SRC), determined from a structure estimation method(2), indicates that 1-amino-2-thiourea is expected to have very high mobility in soil(SRC). Volatilization of 1-amino-2-thiourea from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.6X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(2). 1-Amino-2-thiourea is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.0087 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Utilizing the Japanese MITI test, 0% of the theoretical BOD was reached in 4 weeks indicating that biodegradation in soil is not an important environmental fate process(3).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 16(SRC), determined from a structure estimation method(2), indicates that 1-amino-2-thiourea is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 6.6X10-10 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). 1-Amino-2-thiourea may undergo hydrolysis in the environment due to functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(4), BCFs of 3.8-4.2 and <39 in carp (Cyprinus carpio)(5), suggest bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 0% of the theoretical BOD was reached in 4 weeks indicating that biodegradation in water is not an important environmental fate process(5).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-amino-2-thiourea, which has an estimated vapor pressure of 0.008 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-amino-2-thiourea is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hours(SRC), calculated from its rate constant of 8.4X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase 1-amino-2-thiourea may be removed from the air by wet and dry deposition(SRC). 1-Amino-2-thiourea contains chromophores that absorb at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 1-amino-2-thiourea with photochemically-produced hydroxyl radicals has been estimated as 8.4X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 4 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1-Amino-2-thiourea may undergo hydrolysis in the environment due to functional groups that hydrolyze under environmental conditions(2). 1-Amino-2-thiourea contains chromophores that absorb at wavelengths >290 nm(2) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

BCFs of 3.8-4.2 and <39 were reported using carp (Cyprinus carpio) which were exposed to 0.4 and 0.04 mg/L of 1-amino-2-thiourea over a 6-week period, respectively(1). According to a classification scheme(2), this BCF range suggests bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-amino-2-thiourea can be estimated to be 16(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-amino-2-thiourea is expected to have very high mobility in soil.

The Henry's Law constant for 1-amino-2-thiourea is estimated as 6.6X10-10 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 1-amino-2-thiourea is expected to be essentially nonvolatile from water and moist soil surfaces(2). 1-Amino-2-thiourea is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.0087 mm Hg(SRC), determined from a fragment constant method(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1341 workers (1152 of these were female) were potentially exposed to 1-amino-2-thiourea in the US(1). Occupational exposure to 1-amino-2-thiourea may occur through inhalation of dust and dermal contact with this compound at workplaces where 1-amino-2-thiourea is produced or used(SRC).

Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools. (See all compounds classified as Convulsants.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

Glutamic acid decarboxylase activity in mouse brain homogenates was reduced after pretreatment with thiosemicarbazide.

This material is highly toxic by ingestion. May induce goiter and cause delayed toxic effects in blood and skin. May be mutagenic in human cells. (EPA, 1998)

Warning: Highly toxic by ingestion. May be mutagenic in human cells. Signs and Symptoms of Thiosemicarbazide Exposure: Signs and symptoms of acute exposure to thiosemicarbazide may include eye and skin irritation, excessive salivation, vomiting, pulmonary edema, pleural effusions, central nervous system stimulation, and seizures. Emergency Life-Support Procedures: Acute exposure to thiosemicarbazide may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to thiosemicarbazide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to thiosemicarbazide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 3. Remove contaminated clothing and shoes as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas thoroughly with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. DO NOT induce vomiting. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 30 to 100 g (1 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 30 to 100 g (1 to 3-1/2 oz) is recommended for adults. 6. Transport to health care facility. (EPA, 1998)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/amines and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/amines and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/amines and related compounds/

/SURVEILLANCE/ In the manufacture of rubber, irritant contact dermatitis may occur from a variety of acids, alkalis, detergents, and solvents used in the process. Allergic contact dermatitis occurs not infrequently and is almost always due to an organic accelerator or antioxidant. While the list of potential sensitizing accelerators and antioxidants is enormous, common allergens include ... thioureas. /Thioureas/

N-aminothiourea

Grades: technical and pure.

Hydrazinecarbothioamide: ACTIVE|Thiosemicarbazide is effective for control of bacterial leaf blight of rice when applied around rice plant roots.

OSW Method 3640A. Gel Permeation Chromatography (GPC) Cleanup Procedure.