1,2,2,6,6-Pentamethylpiperidine
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1,2,2,6,6-Pentamethylpiperidine
structure -
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CAS No:
79-55-0
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Formula:
C10H21N
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Chemical Name:
1,2,2,6,6-Pentamethylpiperidine
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Synonyms:
Piperidine,1,2,2,6,6-pentamethyl-;1,2,2,6,6-Pentamethylpiperidine;M&B 4486;Pempidine;Pyrilene;N-Methyl-2,2,6,6-tetramethylpiperidine;2,2,6,6,N-Pentamethylpiperidine;N,2,2,6,6-Pentamethylpiperidine
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Pempidine is a ganglion-blocking drug, introduced as an oral treatment for hypertension.
1,2,2,6,6-pentamethylpiperidine is a member of piperidines.|A nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs.
1,2,2,6,6-Pentamethylpiperidine Basic Attributes
155.28
155.28
103806
201-211-2
N5I18JI9D6
DTXSID7046962
2933399090
Characteristics
3.2
2.3
Clear colorless to light yellow Liquid
0.858 g/mL at 25 °C(lit.)
<25 °C
147 °C
122 °F
n20/D 1.460(lit.)
soluble in toluene, dimethylformamide.
Flammables area
LD50 orl-mus: 275 mg/kg NATUAS 184,1707,59
Safety Information
Ⅲ
3
UN 1992 3/PG 3
3
10-22-36/37/38
26-36/37
TN2190000
Xn
P261-P301 + P310-P305 + P351 + P338
H226-H301-H315-H319-H335
|Danger|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P310, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 43 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery. (See all compounds classified as Ganglionic Blockers.)|Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses. (See all compounds classified as Nicotinic Antagonists.)
Pempidine
1,2,2,6,6-Pentamethylpiperidine Use and Manufacturing
1,2,2,6,6-Pentamethylpiperidine is used in the synthesis of BN-fused polycyclic aromatic molecules for potential application to electronic materials and apparatus. In addition, it is a catalyst for the chemoselective silylation of benzylic alcohols.
Piperidine, 1,2,2,6,6-pentamethyl-: ACTIVE
Pharmaceuticals
Computed Properties
Molecular Weight:155.28
XLogP3:2.3
Hydrogen Bond Acceptor Count:1
Exact Mass:155.167399674
Monoisotopic Mass:155.167399674
Topological Polar Surface Area:3.2
Heavy Atom Count:11
Complexity:131
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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