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Chloramphenicol base

Chloramphenicol base structure

CAS No:
716-61-0
Formula:
C9H12N2O4
Chemical Name:
Chloramphenicol base
Synonyms:
1,3-Propanediol,2-amino-1-(4-nitrophenyl)-,(1R,2R)-;1,3-Propanediol,2-amino-1-(p-nitrophenyl)-,D-threo-(-)-;1,3-Propanediol,2-amino-1-(4-nitrophenyl)-,[R-(R*,R*)]-;(1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol;(-)-threo-1-(p-Nitrophenyl)-2-amino-1,3-propanediol;D-(-)-trans-1-p-Nitrophenyl-2-amino-1,3-propanediol;D-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol;D-threo-(1R,2R)-1-p-Nitrophenyl-2-amino-1,3-propanediol;D-(-)-threo-1-p-Nitrophenyl-2-amino-1,3-propanediol;Chloramphenicol base;Levoamine;Chloramphenicol D base;D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol;D-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol;D-1-(p-Nitrophenyl)-2-aminopropane-1,3-diol;(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol;(1R,2R)-threo-(-)-1-(4-Nitrophenyl)-2-amino-1,3-propanediol;(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol;(1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol;7008-69-7;21792-00-7;21792-01-8;25126-23-2;213530-48-4
Categories:
Biochemical Engineering > Amino Acids and Derivatives

Description

light yellow powder

(R,R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol is a diol that is propane 1,3-diol bearing additional amino and 4-nitrophenyl substituents at positions 2 and 1 respectively. It is an amino alcohol, a diol and a C-nitro compound.

Chloramphenicol base Basic Attributes

Molecular Weight：

212.2

Exact Mass：

212.20

EC Number：

211-938-7

DSSTox ID：

DTXSID80221832

HScode：

29221990

Characteristics

PSA：

112

XLogP3：

-0.7

Appearance：

Light yellow Powder

Density：

1.4±0.1 g/cm3

Melting Point：

162-163 °C

Boiling Point：

451.9°C at 760 mmHg

Flash Point：

227.1±28.7 °C

Refractive Index：

1.630

Storage Conditions：

−20°C

Safety Information

Transport codes：

UN 3259 8/PG 3

wgk germany：

hazard class code：

22-36/37/38-45

safety instructions：

26-45-53-22

RTECS Number：

TY3100000

Marks：

Xn,T

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (95.35%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 43 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

1-(4'-nitrophenyl)-2-aminopropane-1,3-diol

Chloramphenicol base Use and Manufacturing

Methods of Manufacturing

It is obtained by reduction, hydrolysis, neutralization and resolution of p-nitro-α-acetamido-β-hydroxyphenylacetone.

Uses

Chloramphenicol base is the parent 4-nitrophenylpropylamine formed by the hydrolysis of the dichloroacetamide of chloramphenicol and is a degradation product commonly encountered with commercial production of chloramphenicol. Chloramphenicol base has no antibiotic activity but has played an integral role in the synthesis and SAR of new generation antibiotics, notably thiamphenicol and experimental analogues, bromamphenicol and methamphenicol.

Computed Properties

Molecular Weight:212.20
XLogP3:-0.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:212.07970687
Monoisotopic Mass:212.07970687
Topological Polar Surface Area:112
Heavy Atom Count:15
Complexity:211
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Chloramphenicol base

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol

CAS No.: 716-61-0

Content: 99.00%

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(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol cas716-61-0

CAS No.: 716-61-0

Grade: Pharmaceutical grade

Content: 99%

Inquiry
Shandong Ailike New Material Technology Contact Supplier

CN
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(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol

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CAS No.: 716-61-0

Grade: Pharmaceutical grade

Content: 99%

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Guide of Chloramphenicol base

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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