2'-Fluoro-2'-deoxyuridine
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2'-Fluoro-2'-deoxyuridine
structure -
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CAS No:
784-71-4
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Formula:
C9H11FN2O5
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Chemical Name:
2'-Fluoro-2'-deoxyuridine
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Synonyms:
1-(2'-FLUORO-2'-DESOXY-BETA-D-RIBOFURANOSYL)URACIL;2,4(1H,3H)-PYRIMIDINEDIONE, 1-(2-DEOXY-2-FLUORO-BETA-D-RIBOFURANOSYL);2'-FLUORO-2'-DESOXY-URIDINE;2'-FLUORO-D-URIDINE;2'-FUDR;2'-FU;2'-DEOXY-2'-FLUOROURIDINE (2'-FLUORO-2'- DEOXYURIDINE, 2'-FU);2'-Deoxy-2'-fluoro-D-uridine
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CAS No:
Description
White to almost white crystalline powder
A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.
2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity.
2'-Fluoro-2'-deoxyuridine Basic Attributes
246.19
246.065201
1806241-263-5
Y2YC903QW8
White to Off-white
29389090
Characteristics
99.1
-1
White to Off-white Powder
1.63±0.1 g/cm3(Predicted)
147.0 to 153.0 °C
53 ° (C=0.3, H2O)
soluble in water
9.39±0.10(Predicted)
under inert gas (nitrogen or Argon) at 2-8°C
Safety Information
II
4.1
UN 3181 4.1/PG 2
1
Xn
22-36/37/39
Xn
S22; S36/37/39
20/21/22-40
|Warning|H228 (100%): Flammable solid [Danger Flammable solids]|P210, P240, P241, P280, and P370+P378|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory.
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
2'fluoro-2'-deoxyuridine
2'-Fluoro-2'-deoxyuridine Use and Manufacturing
A component incorporated into therapeuticoligonucleotides to combat prostate and breast cancer.
Computed Properties
Molecular Weight:246.19
XLogP3:-1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:246.06519962
Monoisotopic Mass:246.06519962
Topological Polar Surface Area:99.1
Heavy Atom Count:17
Complexity:374
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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