Fluoroethylene

46.04

46.04

200-832-6

2598465ICX

0598

1860

DTXSID3021435

Colorless gas [Note: Shipped as a liquefied compressed gas].

0

1.19 /Estimated/

Vinyl fluoride, stabilized appears as a colorless gas with a faint ethereal odor. Shipped as a confined liquid under its vapor pressure. Any leak can either be liquid or vapor. Contact with the liquid can cause frostbite. Easily ignited. Vapors are heavier than air. Can asphyxiate by the displacement of air. Under prolonged exposure to fire or intense heat the containers may rupture violently and rocket.

0.707 at 32°F

-160.5 °C

-72 °C

NA (Gas)

1.289

Insoluble

Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ) that bears appropriate label. An inventory should be kept, showing quantity of carcinogen & date it was acquired Facilities for dispensing should be contiguous to storage area.

25.2 atm

1.60

Inhalation-Rat LC 80000 PPM/12.5 hours

Flammable; decomposes toxic hydrogen fluoride gas in case of heat

vol% in air: 2.61.7

Faint, ethereal odor.

5.56e-12 cm3/molecule*sec

Henry's Law constant = 1.2X10-1 atm-cu m/mole at 25 °C /Estimated/

1 mg/cu m = 2.62 ppm|Liquid molar volume = 0.053091 cu m/kmol; Heat of formation = -1.3891X10+08 J/kmol|Hydroxyl radical reaction rate constant = 5.56X10-12 cu cm/molec-sec at 25 °C

Highly flammable, reacts with air to form peroxides

Fluorinated Organic Compounds

Highly Flammable

VINYL FLUORIDE is light sensitive, peroxidizable monomer may initiate exothermic polymerization of the bulk material [Handling Chemicals Safely 1980. p. 958]. Sensitive to many oxidants.

860 °F (USCG, 1999)|860 °F (460 °C)|385 °C

-1.01E+8 J/kmol

10.37 eV

Lower flammable limit: 2.6% by volume; Upper flammable limit: 21.7% by volume|Flammable Gas

The vapour is heavier than air and may travel along the ground; distant ignition possible.

2.2243X10+07 J/kmol at melting point

Critical tempurature = 54.7 °C; Critical pressure = 5.1 MPa

2.1

1860

12-40

9-16-23-36/37/39

YZ7351000

F

Treasury is ventilated, low temperature and dry; stored separately from oxidant

Flammable

Explosive when mixed with air

P201, P202, P210, P260, P261, P271, P281, P304+P340, P308+P313, P312, P314, P377, P381, P403, P403+P233, P405, P410+P403, P501

H220

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": HEPA (high-efficiency particulate arrestor) filters ... can be disposed of by incineration. For spent charcoal filters, the adsorbed material can be stripped off at high temp & carcinogenic wastes generated by this treatment conducted to & burned in an incinerator. ... LIQUID WASTE: ... Disposal should be carried out by incineration at temp that ... ensure complete combustion. SOLID WASTE: Carcasses of lab animals, cage litter & misc solid wastes ... should be disposed of by incineration at temp high enough to ensure destruction of chem carcinogens or their metabolites. /Chemical Carcinogens/|For more Disposal Methods (Complete) data for VINYL FLUORIDE (6 total), please visit the HSDB record page.

During ozonolysis of vinyl fluoride an explosive solid residue is produced, and the volatile ozonide, trapped at -63 °C, may explode spontaneously or during removal by syringe.

National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Vinyl Fluoride (875-02-5) is listed as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s188viny.pdf]|Kennedy GL; Crit Rev Toxicol 21 (2): 149-70 (1990). A review of the toxicology of fluorine containing monomers.|Evidence supporting the need for evaluating the toxicity of fluoroalkenes is discussed. Chemical properties, potential for worker exposure, and adequacy of information on oncogenicity, mutagenicity, teratogenicity, and other other effects are reviewed.[USEPA; Fluoroalkenes; Response to the Interagency Testing Committee; Fed Regist 46 (210): 53704-8 (1981)]|The U.S. high production volume (HPV) chemicals are those which are manufactured in or imported into the United States in amounts equal to or greater than one million pounds per year. Robust Summaries include health effects, ecotoxicity data, and environmental fate information for selected chemicals. EPA/Office of Pollution Prevention and Toxics; High Production Volume (HPV) Challenge Program's Robust Summaries and Test Plans. Available from: http://www.epa.gov/chemrtk/viewsrch.htm on Fluoroethylene as of November 3, 2004.

Special Hazards of Combustion Products: Toxic hydrogen fluoride gas is generated in a fire. Behavior in Fire: Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back. Containers may explode. (USCG, 1999)|Extremely flammable. Gas/air mixtures are explosive.|Carcinogens, Flammable - 4th degree, Reactive - 2nd degree

|Danger|H220 (100%): Extremely flammable gas [Danger Flammable gases]|P201, P202, P210, P260, P281, P308+P313, P314, P377, P381, P403, P405, P410+P403, and P501|Aggregated GHS information provided by 148 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H350i: May cause cancer by inhalation [Danger Carcinogenicity]|P201, P202, P281, P308+P313, P405, and P501|H220: Extremely flammable gas [Danger Flammable gases]|P201, P202, P210, P260, P261, P271, P281, P304+P340, P308+P313, P312, P314, P377, P381, P403, P403+P233, P405, P410+P403, and P501

Excerpt from ERG Guide 116P [Gases - Flammable (Unstable)]: As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 800 meters (1/2 mile). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, consider initial evacuation for 1600 meters (1 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 116P [Gases - Flammable (Unstable)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Stop leak if you can do it without risk. Do not touch or walk through spilled material. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Isolate area until gas has dispersed. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin from becoming frozen from contact with the liquid or from contact with vessels containing the liquid. Eyes: Wear appropriate eye protection to prevent eye contact with the liquid that could result in burns or tissue damage from frostbite. Wash skin: No recommendation is made specifying the need for washing the substance from the skin (either immediately or at the end of the work shift). Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Quick drench facilities and/or eyewash fountains should be provided within the immediate work area for emergency use where there is any possibility of exposure to liquids that are extremely cold or rapidly evaporating. (NIOSH, 2016)|Protective gloves; safety glasses; self-contained breathing apparatus.|Wear appropriate personal protective clothing to prevent the skin from becoming frozen from contact with the liquid or from contact with vessels containing the liquid.|Wear appropriate eye protection to prevent eye contact with the liquid that could result in burns or tissue damage from frostbite.|Quick drench facilities and/or eyewash fountains should be provided within the immediate work area for emergency use where there is any possibility of exposure to liquids that are extremely cold or rapidly evaporating.|For more Personal Protective Equipment (PPE) (Complete) data for VINYL FLUORIDE (11 total), please visit the HSDB record page.|(See protection codes)

Ignites in presence of heat or source of ignition.|Flammable, dangerous fire ... risk.

Explosive limits: 2.6% (Lower); 21.7% (Upper).|Explosive limits , vol% in air: 2.6-21.7

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /Vinyl fluoride, stabilized/|Evacuation: If fire becomes uncontrollable or container is exposed to direct flame - consider evacuation of one-half (1/2) mile radius. /Vinyl fluoride, stabilized/|In case of fire: Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out; in other cases extinguish with powder, carbon dioxide. In case of fire: keep cylinder cool by spraying with water. ... NEVER direct water jet on liquid ...

Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors. /Vinyl fluoride, stabilized/|Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Approach fire with caution. /Vinyl fluoride, stabilized/|Evacuation: If material leaking (not on fire) consider evacuation downwind area based on amount of material spilled, location and weather conditions. /Vinyl fluoride, stabilized/|For more Preventive Measures (Complete) data for VINYL FLUORIDE (14 total), please visit the HSDB record page.

/GUIDE 116P: GASES - FLAMMABLE (UNSTABLE)/ Fire or Explosion: EXTREMELY FLAMMABLE. Will be easily ignited by heat, sparks or flames. Will form explosive mixtures with air. ... Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Vapors from liquefied gas are initially heavier than air and spread along ground. Vapors may travel to source of ignition and flash back. Cylinders exposed to fire may vent and release flammable gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket. /Vinyl fluoride, inhibited; Vinyl fluoride, stabilized/|/GUIDE 116P: GASES - FLAMMABLE (UNSTABLE)/ Health: Vapors may cause dizziness or asphyxiation without warning. Some may be toxic if inhaled at high concentrations. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating and/or toxic gases. /Vinyl fluoride, inhibited; Vinyl fluoride, stabilized/|/GUIDE 116P: GASES - FLAMMABLE (UNSTABLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. /Vinyl fluoride, inhibited; Vinyl fluoride, stabilized/|/GUIDE 116P: GASES - FLAMMABLE (UNSTABLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Vinyl fluoride, inhibited; Vinyl fluoride, stabilized/|For more DOT Emergency Guidelines (Complete) data for VINYL FLUORIDE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.|PRECAUTIONS FOR "CARCINOGENS": Procurement ... of unduly large amt ... should be avoided. To avoid spilling, carcinogens should be transported in securely sealed glass bottles or ampoules, which should themselves be placed inside strong screw-cap or snap-top container that will not open when dropped & will resist attack from the carcinogen. Both bottle & the outside container should be appropriately labelled. ... National post offices, railway companies, road haulage companies & airlines have regulations governing transport of hazardous materials. These authorities should be consulted before ... material is shipped. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": When no regulations exist, the following procedure must be adopted. The carcinogen should be enclosed in a securely sealed, watertight container (primary container), which should be enclosed in a second, unbreakable, leakproof container that will withstand chem attack from the carcinogen (secondary container). The space between primary & secondary container should be filled with absorbent material, which would withstand chem attack from the carcinogen & is sufficient to absorb the entire contents of the primary container in the event of breakage or leakage. Each secondary container should then be enclosed in a strong outer box. The space between the secondary container & the outer box should be filled with an appropriate quantity of shock-absorbent material. Sender should use fastest & most secure form of transport & notify recipient of its departure. If parcel is not received when expected, carrier should be informed so that immediate effort can be made to find it. Traffic schedules should be consulted to avoid ... arrival on weekend or holiday ... /Chemical Carcinogens/

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 ppm.|Recommended Exposure Limit: Ceiling Value: 5 ppm.

Evacuate danger area! Consult an expert! Ventilation. NEVER direct water jet on liquid. Personal protection: self-contained breathing apparatus. Remove fumes with fine water spray. Do NOT wash away into sewer.

Fireproof. Separated from strong oxidants. Cool. Store only if stabilized.

A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

The liquid may cause frostbite. The substance may cause effects on the central nervous system.

This substance is probably carcinogenic to humans.

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting.

AVOID ALL CONTACT!

Use ventilation, local exhaust or breathing protection.

Cold-insulating gloves. Protective clothing.

Wear safety goggles or eye protection in combination with breathing protection.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 4 - Materials that rapidly or completely vaporize at atmospheric pressure and normal ambient temperature or that are readily dispersed in air and burn readily.| 2 - Materials that readily undergo violent chemical changes at elevated temperatures and pressures.|W - No water: Materials that react violently or explosively with water.| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.

practically nontoxic

It is not known whether vinyl fluoride occurs as a natural product(1).

Vinyl fluoride's production and use as a monomer in the synthesis of poly(vinyl fluoride)(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 24(SRC), determined from a structure estimation method(2), indicates that vinyl fluoride is expected to have very high mobility(SRC). Volatilization of vinyl fluoride from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.12 atm-cu m/mole(SRC), using a fragment constant estimation method(3). The potential for volatilization of vinyl fluoride from dry soil surfaces may exist(SRC) based upon an extrapolated vapor pressure of 1.98X10+4 mm Hg(4). Insufficient data are available to predict the relative importance or rate of biodegradation in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 24(SRC), determined from a structure estimation method(2), indicates that vinyl fluoride is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2 hrs and 3 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 2(SRC), from an estimated log Kow of 1.2(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Insufficient data are available to predict the relative importance or rate of biodegradation in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), vinyl fluoride, which has an extrapolated vapor pressure of 1.98X10+4 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase vinyl fluoride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3 days(SRC), calculated from its rate constant of 5.56X10-12 cu cm/molecule-sec at 25 deg(3). Vinyl fluoride also reacts with ozone(4), which will contribute to its atmospheric degradation with an estimated half-life of about 16 days(SRC).

The rate constant for the vapor-phase reaction of vinyl fluoride with photochemically-produced hydroxyl radicals has been measured as 5.6X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 3 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Vinyl fluoride is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2) nor to directly photolyze due to the lack of absorption in the environmental UV spectrum. The rate constant for the vapor-phase reaction of vinyl fluoride with ozone has been measured as 7.0X10-19 cu cm/molecule-sec at 21 °C(SRC) and 1.4X10-19 cu cm/molecule-sec at -13 °C(3). This corresponds to an atmospheric half-life of about 16 days(SRC) at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(4).

An estimated BCF of 2 was calculated for vinyl fluoride(SRC), using an estimated log Kow of 1.19(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC), provided the compound is not altered physically or chemically once released into the environment.

Using a structure estimation method based on molecular connectivity indices(1), the Koc for vinyl fluoride can be estimated to be 24(SRC). According to a classification scheme(2), this estimated Koc value suggests that vinyl fluoride is expected to have very high mobility in soil.

The Henry's Law constant for vinyl fluoride is estimated as 0.12 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that vinyl fluoride is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 3 days(SRC). Vinyl fluoride's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of vinyl fluoride from dry soil surfaces may exist(SRC) based upon an extrapolated vapor pressure of 1.98X10+4 mm Hg(3).

Occupational exposure to vinyl fluoride may occur through inhalation and dermal contact with this compound at workplaces where vinyl fluoride is produced or used(SRC). Surveys made at a vinyl fluoride manufacturing plant and a vinyl fluoride polymerization plant showed that exposure levels for production and control operations were generally <4mg/cu m, while exposures associated with polymer operations ranged from 2-9 mg/cu m, with a time-weighted average of 3.6 mg/cu m(1,2).

Vinyl fluoride was detected (concn not reported) in expired air collected from a control population of humans in a study of expired air constituents from diabetics(1).

Food and Environmental Agents: Effect on Breast-Feeding: Reported Sign or Symptom in Infant or Effect on Lactation: Fluorides: None. /from Table 7/

Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. (See all compounds classified as Carcinogens.)

Rats were exposed in closed inhalation system to levels of halogenated ethylenes. Cmpd with low boiling point were enriched in tissues much less than those with higher boiling point. Metabolic elimination of halogenated ethylenes was saturable, dose-dependent process.|Simple fluoroalkenes are probably biodegradable, demonstrated by increased urinary excretion of free fluoride ion following exposure.|Vinyl fluoride is readily absorbed after its inhalation and reaches a tissue concentration in rats that is 90% of that in the inhaled air.

The first step in the metabolism of ... vinyl fluoride ... has been proposed to involve microsomal oxidation leading to epoxide formation across the double bond. /It has been/ suggested that the resulting oxiranes are highly reactive and therefore can covalently bind to nucleic acids with the eventual end result of mutations and cancer.|Increased exhalation of acetone has been reported to be due to the effects of vinyl fluoride on intermediary metabolism. Intermediate metabolites of vinyl fluoride have been shown to alkylate the heme group of cytochrome P450 enzymes in vitro, suggesting potential inhibition of the metabolism of other substances.|Metabolism, measured by the decline of fluoride in the inhalation chamber, was dose-dependant and saturated after exposure of rats to concentrations greater than 75 ppm. Fluoride ion has been shown to be released from vinyl fluoride oxidative metabolism and released into the urine following acute exposures.|Based on the structural similarity to both vinyl chloride and vinyl bromide, the metabolism of vinyl fluoride is expected to involve microsomal oxidation leading to epoxide formation across the double bond, followed by rearrangement to form the 2-halo(fluoro)acetaldehyde. Both the epoxide and the acetaldehyde are capable of binding to tissue nucleophiles.|For more Metabolism/Metabolites (Complete) data for VINYL FLUORIDE (7 total), please visit the HSDB record page.

Vinyl fluoride, vinyl bromide, fluroxene (2,2,2-trifluoroethyl vinyl ether), and acetylene alkylate the prosthetic heme group of cytochrome P-450 enzymes which catalyze their metabolism. The alkylated heme moiety has been identified in all four cases, after carboxyl group methylation and demetalation, as the dimethyl ether of N-(2-oxoethyl)protoporphyrin IX. ...The formation of the same prosthetic heme adduct with the four substrates requires introduction of an oxygen at the trifluoroethoxy or halide-substituted terminus of the pi bond and reaction of the unsubstituted terminus with a heme nitrogen atom.|...Vinyl halides induce etheno (epsilon) adducts that are identical to those formed after lipid peroxidation. Of these adducts, N2,3-ethenoguanine (epsilon G) is present in greatest amounts in tissues of exposed animals. After exposure to vinyl chloride for four weeks, epsilon G levels attain steady-state concentrations, such that the amount of newly formed adducts equals the number of adducts that are lost each day. ...Exposure to 10 ppm vinyl chloride for five days caused a two- to threefold increase in epsilon G over that of the controls, while four weeks' exposure resulted in a fivefold increase. ...Exposure to 100 ppm vinyl chloride for four weeks caused a 25-fold increase in epsilon G levels over that found in control rats, while exposure to 1100 ppm resulted in a 42-fold increase. The amount of endogenous epsilon G was similar in liver DNA from rats and humans. A comparable response to exposure was seen in rats and mice exposed to 0, 25, 250 or 2500 ppm vinyl fluoride for 12 months. There was a very high correlation between epsilon G levels in rat and mouse liver at 12 months and the incidence of hemangiosarcoma at two years. ...The expression of N-methylpurine-DNA glycosylase mRNA was induced in rat liver after exposure to either 25 or 2500 ppm vinyl fluoride.

Inhalation of vapor causes slight intoxication, some shortness of breath. Liquid may cause frostbite of eyes or skin. (USCG, 1999)

Eye: If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible. Skin: If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Artificial respiration may be needed.

Rinse and then wash skin with water and soap. ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer immediately for medical attention.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with sterile dressings after decontamination ... . /Halogenated aliphatic hydrocarbons and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of myocardial irritability and fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Halogenated aliphatic hydrocarbons and related compounds/

/HUMAN EXPOSURE STUDIES/ /Investigators/ reported polyvinyl fluoride produced no skin reaction when /evaluated/ for irritation and sensitization on 215 human subjects. Contact with liquid vinyl fluoride may cause frost bite, and exposure to the vapor may cause headache or dizziness.|/SIGNS AND SYMPTOMS/ The vapor if inhaled will cause headache or dizziness. Liquid will cause frost bite /on contact/.|/OTHER TOXICITY INFORMATION/ In chronic fluoride poisoning of human beings it has been said that changes in the bones of the skull have sometimes led to optic atrophy through compression of the optic nerves, but no direct toxic effect on these nerves is known. /Fluorides/

fluoroethylene

The substance can be absorbed into the body by inhalation.|inhalation, skin and/or eye contact (liquid)

headache, dizziness, confusion, incoordination, narcosis, nausea, vomiting; liquid: frostbite

Headache. Dizziness. Confusion. Incoordination. Nausea. Vomiting. Shortness of breath.

ON CONTACT WITH LIQUID: FROSTBITE.

See Skin.

central nervous system

ESSENTIALLY 100% FOR POLYVINYL FLUORIDE PRODUCTION (1975)

Grades or purity: 99.9+%

Plastic material and resin manufacturing|Ethene, fluoro-: ACTIVE|Inhibitor of polymerization: terpene b 0.2%

Vinyl fluoride has been determined in workplace air (1-9 mg/cu m) by collection in poly(tetrafluoroethylene) bags and analysis by gas chromatography

Fire Hazards -> Carcinogens, Flammable - 4th degree, Reactive - 2nd degree