VINYL FLUORIDE 99% Gas Dideu

VINYL FLUORIDE

vinylfluoride(vf);vinylfluoride,inhibited;Fluoroethene~Fluoroethylene;Vinylfluorideinhibitedwithdlimonene;VINYL FLUORIDE 98%;inhibied;vinyl;Vinylfluoride98%

75-02-5

C2H3F

InChIKey=XUCNUKMRBVNAPB-UHFFFAOYSA-N

46.04

46.04

200-832-6

2598465ICX

0598

1860

TSCA listed

DTXSID3021435

Colorless gas [Note: Shipped as a liquefied compressed gas].

2903290000

Organic Reagents

0

1.19 /Estimated/

Vinyl fluoride, stabilized appears as a colorless gas with a faint ethereal odor. Shipped as a confined liquid under its vapor pressure. Any leak can either be liquid or vapor. Contact with the liquid can cause frostbite. Easily ignited. Vapors are heavier than air. Can asphyxiate by the displacement of air. Under prolonged exposure to fire or intense heat the containers may rupture violently and rocket.

0,615 g/cm3

-160,5°C

-72°C

NA (Gas)

1.34

Insoluble

Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ) that bears appropriate label. An inventory should be kept, showing quantity of carcinogen & date it was acquired Facilities for dispensing should be contiguous to storage area.

25.2 atm

1.60

VF is readily absorbed after administration by inhalation. Its metabolism is saturable and dose dependent.VF is metabolized via the same pathway as for other carcinogenic vinyl halides like vinyl chloride (VC) and vinyl bromide. VF is metabolized to DNA-reactive intermediates fluoroethylene oxide and fluoroacetaldehyde via a human cytochrome P450 2E1 (CYP) dependent pathway. These reactive metabolites react with DNA bases and form promutagenic DNA adducts mainly 1, N6-ethenoadenine and N2,3- -ethenoguanine and cause DNA miscoding by modifying base-pairing sites. These cyclic etheno adducts lead to misincorporation of bases upon replication or transcription and cause critical lesions in VF-induced carcinogenesis. The fluoroacetaldehyde is metabolized to fluoroacetic acid, a potent inhibitor of the Krebs cycle. As a consequence, its incorporation into the citric acid cycle disrupts energy metabolism and leads to increased production of mitochondrial acetyl coenzyme A and causes excretion of ketone bodies and free F. So, administration of VF has been shown to increase acetone exhalation and F excretion in urine of experimental animals. On the other hand, fluoroacetaldehyde alkylates the prosthetic heme group of CYP resulting irreversible inactivation of the enzyme, which catalyzes the VF metabolism. The alkylate has been identified as N-(2-oxoethyl) protoporphyrin IX or green porphyrin.

Flammable; decomposes toxic hydrogen fluoride gas in case of heat

vol% in air: 2.61.7

Faint, ethereal odor.

5.56e-12 cm3/molecule*sec

8.2×10-5mol/(m3Pa) at 25℃, HSDB (2015)

1 mg/cu m = 2.62 ppm|Liquid molar volume = 0.053091 cu m/kmol; Heat of formation = -1.3891X10+08 J/kmol|Hydroxyl radical reaction rate constant = 5.56X10-12 cu cm/molec-sec at 25 °C

Highly flammable, reacts with air to form peroxides

Fluorinated Organic Compounds

Highly Flammable

VINYL FLUORIDE is light sensitive, peroxidizable monomer may initiate exothermic polymerization of the bulk material [Handling Chemicals Safely 1980. p. 958]. Sensitive to many oxidants.

860 °F (USCG, 1999)|860 °F (460 °C)|385 °C

-1.01E+8 J/kmol

10.37 eV

Lower flammable limit: 2.6% by volume; Upper flammable limit: 21.7% by volume|Flammable Gas

The vapour is heavier than air and may travel along the ground; distant ignition possible.

2.2243X10+07 J/kmol at melting point

Critical tempurature = 54.7 °C; Critical pressure = 5.1 MPa