 Home > Encyclopedia > Aceclidine

Aceclidine

Aceclidine structure

CAS No:
827-61-2
Formula:
C9H15NO2
Chemical Name:
Aceclidine
Synonyms:
1-Azabicyclo[2.2.2]octan-3-ol,3-acetate;3-Quinuclidinol,acetate (ester);1-Azabicyclo[2.2.2]octan-3-ol,acetate (ester);3-Quinuclidinol,acetate;Aceclidine;3-Acetoxyquinuclidine;3-Hydroxyquinuclidine acetate;Aceclidin;(±)-3-Acetoxyquinuclidine;3-Quinuclidinyl acetate;dl-3-Quinuclidinol acetate;NSC 657843;1-Azabicyclo[2.2.2]octan-3-yl acetate;72353-53-8
Categories:
Active Pharmaceutical Ingredients > Specialty Drugs

Description

Acetic acid 1-azabicyclo[2.2.2]octan-3-yl ester is a member of quinuclidines.|Aceclidine has been marketed in Europe but has not been used clinically in the United States. It is used in the treatment of open-angle glaucoma and is a parasympathomimetic agent.

Aceclidine Basic Attributes

Molecular Weight：

169.2209

Exact Mass：

169.22

EC Number：

212-574-1

NSC Number：

758239|657843

DSSTox ID：

DTXSID2045658

ATC Code：

S - Sensory organs

HScode：

2933990090

Characteristics

PSA：

29.5

XLogP3：

0.7

Density：

1.0873 (rough estimate)

Boiling Point：

73-74 °C @ Press: 0.4 Torr

Flash Point：

85ºC

Toxicity：

Subcutaneous-rat LD50: 225 mg/kg; oral-mouse LD50: 165 mg/kg

Flammability characteristics：

Flammable; decomposes by heating to release toxic nitrogen oxide fumes

Collision Cross Section：

136.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Storage features：

Warehouse ventilated, low temperature and dry

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here. (See all compounds classified as Miotics.)|Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here. (See all compounds classified as Parasympathomimetics.)

MeSH Entry Terms：

aceclidin

Aceclidine Use and Manufacturing

analgesic (topical), depletes Substance P, neurotoxic

Computed Properties

Molecular Weight:169.22
XLogP3:0.7
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:169.110278721
Monoisotopic Mass:169.110278721
Topological Polar Surface Area:29.5
Heavy Atom Count:12
Complexity:185
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Aceclidine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Aceclidine

CAS No.: 827-61-2

Content: 99.00%

Inquiry
Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

Aceclidine 99% Crystalline Powder Dideu

CAS No.: 827-61-2

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Compound Net Biotechnology Inc. Contact Supplier

CN
2 YRS

Business licensed Certified factory

Manufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acid

827-61-2 1-azabicyclo[2.2.2]octan-3-yl acetate

CAS No.: 827-61-2

Grade: Industrial Grade

Content: 95%

Inquiry