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5-Methyl-2′-deoxycytidine

5-Methyl-2′-deoxycytidine structure

CAS No:
838-07-3
Formula:
C10H15N3O4
Chemical Name:
5-Methyl-2′-deoxycytidine
Synonyms:
Cytidine,2′-deoxy-5-methyl-;2′-Deoxy-5-methylcytidine;5-Methyl-2′-deoxycytidine;5-Methyldeoxycytidine;2′-Deoxy-5′-methylcytidine;1867-19-2
Categories:
Biochemical Engineering > Nucleoside Drugs

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Description

5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation[1][2].

5-methyl-2'-deoxycytidine is a 2'-deoxycytidine.

5-Methyl-2′-deoxycytidine Basic Attributes

Molecular Weight：

241.24

Exact Mass：

241.24

EC Number：

212-655-1

HScode：

29389090

Characteristics

PSA：

108

XLogP3：

-1.4

Appearance：

White to Off-white Powder

Density：

1.6±0.1 g/cm3

Melting Point：

217-219 °C(lit.)

Boiling Point：

492.8°C at 760 mmHg

Flash Point：

251.9±31.5 °C

Refractive Index：

1.694

Water Solubility：

soluble in water.

Storage Conditions：

−20°C

Safety Information

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36-24/25

RTECS Number：

HA3860000

Marks：

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

5-methyl-2'-deoxycytidine

5-Methyl-2′-deoxycytidine Use and Manufacturing

Methods of Manufacturing

General procedure: To a solution of the nucleosides (2–20) in DMF ([substrate]=0.3M, except for 3 and 4, [3, 4]=0.05M) were added PyAOP (1.6 eq) and DBU (1.6 eq). The reaction was stirred at 20°C for 1min. To the reaction solution was added N-nucleophiles (4 eq) (or 1a in THF, conc. NHGeneral procedure: To a solution of the nucleosides (2–20) in DMF ([substrate]=0.3M, except for 3 and 4, [3, 4]=0.05M) were added PyAOP (1.6 eq) and DBU (1.6 eq). The reaction was stirred at 20°C for 1min. To the reaction solution was added N-nucleophiles (4 eq) (or 1a in THF, conc. NH

Uses

5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. It has been used in epigenetics research to investigate the dynamics of DNA methylation pattern in the control of gene expression.

Computed Properties

Molecular Weight:241.24
XLogP3:-1.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:241.10625597
Monoisotopic Mass:241.10625597
Topological Polar Surface Area:108
Heavy Atom Count:17
Complexity:393
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It can improve blood circulation disorders, reduce vascular resistance, increase myocardial oxygen utilization, promote the enhancement of hematopoietic system activity, increase the number of white blood cells, and increase vascular elasticity and prevent vascular sclerosis.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Myo-aminoglycan for injection
Ingredients	This product contains a variety of cardiovascular active substances, the main components of which include atrial peptides, calcitonin gene-related peptides and nucleotides (nucleosides) such as adenosine triphosphate (adenosine), in addition to more than 20 amino acids and their metabolic intermediates.
Indication	There is still a lack of research data and related reports on drug interactions of this product.
Specifications	Peptide 7.0mg and hypoxanthine 1.0mg
Manufacturer	Heilongjiang Jiangshi Pharmaceutical Co., Ltd.

Myo-aminoglycan for injection
Ingredients	This product contains a variety of cardiovascular active substances, the main components of which include atrial peptides, calcitonin gene-related peptides and nucleotides (nucleosides) such as adenosine triphosphate (adenosine), in addition to more than 20 amino acids and their metabolic intermediates.
Indication	There is still a lack of research data and related reports on drug interactions of this product.
Specifications	Peptide 3.5mg and hypoxanthine 0.5mg

Myo-aminoglycan for injection
Ingredients	This product contains a variety of cardiovascular active substances, the main components of which include atrial peptides, calcitonin gene-related peptides and nucleotides (nucleosides) such as adenosine triphosphate (adenosine), in addition to more than 20 amino acids and their metabolic intermediates.
Indication	There is still a lack of research data and related reports on drug interactions of this product.
Specifications	Peptide 8.75mg and hypoxanthine 1.25mg
Manufacturer	Harbin Medisan Pharmaceutical Co., Ltd.

Recommended Suppliers of 5-Methyl-2′-deoxycytidine

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CAS No.: 838-07-3

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Guide of 5-Methyl-2′-deoxycytidine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
Learn More Other Chemicals

5-Methyl-2′-deoxycytidine

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