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INVERTOSE

INVERTOSE structure

CAS No:
8013-17-0
Formula:
C12H24O12
Chemical Name:
INVERTOSE
Synonyms:
INVERTOSE;INVERT SUGAR;calorose;SACCHARIDE HYDROLYSATE;insubeta;inverdex;invert;invertogen
Categories:
Cosmetic Ingredient > Humectant

Description

A mixture of 50% glucose and 50% fructose obtained by the hydrolysis of sucrose. It absorbs water readily and is usually handled only as a syrup. Because of its fructose content, invert sugar is levorotatory in solution and sweeter than sucrose. Invert su

Invert sugar is a direct and indirect food ingredient. It is a mixture of two monosaccharides, glucose and fructose, which results from the hydrolysis of sucrose. Invert sugar is marketed as a component of invert syrups; these syrups also contain sucrose, the proportion depending on the extent of conversion. Invert syrups are considered to be invert sugar in this evaluation. Solids in "total" invert syrups contain 6 percent sucrose whereas those in "medium" invert syrups contain 39 percent sucrose. Invert syrup solids also contain 3 percent polysaccharides and less than 0.5 percent of the monosaccharide D-psicose (an epimer of fructose). The principal highfructose syrup currently sold in the United States is produced by the enzymatic isomerization of starch hydrolyzates, about 95 dextrose equivalent, and contains about the same proportions of dextrose and fructose as "total" invert syrups from sucrose on a dry solids basis. It also contains the di- and higher saccharides that were present in the starch hydrolyzates from which they were derived and less than 0.3 percent D-psicose. Dextrose-levulose syrup produced by the enzymatic isomerization of dextrose solutions contains, in addition to dextrose and levulose, less than 1 percent polysaccharides and less than 0.3 percent D-psicose.1 Invert sugar is a mixture of glucose and fructose that results from the hydrolysis of sucrose in accordance with good manufacturing practices. Invert sugar is marketed as invert sugar syrup and also contains dextrose (glucose), fructose, and sucrose in various amounts as represented by the manufacturer. Invert sugar syrup is a hygroscopic liquid that has a sweet taste. It is very soluble in water, in glycerin, and in glycols; and it is very sparingly soluble in acetone and in ethanol.

Sweet hygroscopic liquid, white or light yellow viscous syrup, sweetness is about 70% to 90% of sucrose. It is levulose, specific optical rotation -40.5° soluble in water, glycerol and ethylene glycol, very slightly soluble in acetone and ethanol. It has reducing properties and can reduce Ferrin's solution.

INVERTOSE Basic Attributes

Molecular Weight：

360.31

Exact Mass：

360.126770

EC Number：

232-393-1

TSCA：

TSCA listed

DSSTox ID：

DTXSID20190816

ATC Code：

C - Cardiovascular system

HScode：

2940.00.6000

Characteristics

PSA：

236.44000

XLogP3：

-6.75600

Density：

1.338[at 20℃]

Boiling Point：

105℃[at 101 325 Pa]

Flash Point：

301.5ºC

Water Solubility：

almost transparency

Experimental Properties：

Reduces Fehling's soln and can be fermented|1 L OF 10% INVERT SUGAR SOLN IN WATER CONTAINS 100 G OF CARBOHYDRATE & PROVIDES 400 CALORIES OF ENERGY

Safety Information

Disposal Methods：

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

FDA Requirements：

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

Toxicity

Natural Pollution Sources：

Cane juice contains ca 5-10 wt% invert sugar (based on sucrose), whereas in healthy beet sugar it is 1%

Drug Information

Therapeutic Uses：

Cariogenic Agents|SOLN CONTAINING 25% TO 50% DEXTROSE ARE USED IN PARENTERAL HYPERALIMENTATION. THESE MAY BE ADMIN SLOWLY TO PROVIDE AS MUCH AS 3,000-4,000 CALORIES DAILY, & MUST BE GIVEN VIA THE SUPERIOR VENA CAVA OR OTHER EQUALLY LARGE VEIN. /DEXTROSE/|SOLN CONTAINING 50% TO 75% DEXTROSE DECR THE FREQUENCY OF DIALYSIS IN PATIENTS WITH RENAL FAILURE. /DEXTROSE/

Drug Warnings：

IF THE INDIVIDUAL PATIENT'S CAPACITY TO UTILIZE DEXTROSE IS EXCEEDED, GLYCOSURIA & DIURESIS WILL OCCUR. /DEXTROSE/|10% SOLN OF INVERT SUGAR BUFFERED TO PH 6.8 WAS FOUND TO CAUSE SIGNIFICANTLY LOWER INCIDENCE OF THROMBOPHLEBITIS THAN SOLN OF SAME STRENGTH WITH PH BETWEEN 3.5 AND 5.4 FOLLOWING INTRAVENOUS INJECTION OF 500 ML QUANTITIES IN 76 PATIENTS.|DEXTROSE INJECTION SHOULD NOT BE USED AS A DILUENT FOR BLOOD BECAUSE IT CAUSES CLUMPING OF RED BLOOD CELLS &, POSSIBLY, HEMOLYSIS. THIS CAN BE AVOIDED BY USING 5% DEXTROSE IN 0.2% OR 0.11% SODIUM CHLORIDE INJECTION. /DEXTROSE/|SUBCUTANEOUS /ADMIN OF INVERT SUGAR/: GENERALLY DEEMED INADVISABLE.|For more Drug Warnings (Complete) data for INVERT SUGAR (7 total), please visit the HSDB record page.

MeSH：

Substances that promote DENTAL CARIES. (See all compounds classified as Cariogenic Agents.)|Substances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed) (See all compounds classified as Sweetening Agents.)

Absorption：

LESS THAN 2% OF SUGAR IS EXCRETED IN URINE WHEN 1 L OF 10% INVERT SUGAR SOLN IS INFUSED IN 1 HR. WHEN GIVEN OVER A LONGER PERIOD OF TIME INVERT SUGAR IS COMPLETELY UTILIZED AND NONE IS EXCRETED IN URINE.

Human Toxicity Excerpts：

SC ADMIN IS NOT DESIRABLE BECAUSE SOLN ARE IRRITATING...CAUSE LEACHING OF EXTRACELLULAR WATER & ELECTROLYTES, & MAY DISTEND TISSUE & LEAD TO NECROSIS. ...LEACHING...MAY RESULT IN ANURIA & OLIGURIA BECAUSE OF CIRCULATORY FAILURE.../IN THOSE WITH/ ELECTROLYTE & WATER IMBALANCE. /DEXTROSE/

MeSH Entry Terms：

invert sugar

INVERTOSE Use and Manufacturing

Methods of Manufacturing

Acid hydrolysis of sucrose: take 65% sucrose solution as raw material, add dilute hydrochloric acid to 0.25%, after acting at 52℃ for 1h, neutralize with sodium bicarbonate. Invertase is used to convert sucrose at a pH of 3 to 4. The conversion rate of sucrose can reach 96%.

Uses

Sweetener; Humectant. It is widely used in a variety of foods, especially candy (to prevent hair sand), cakes (moisturizing), etc. It is also a raw material for brewing.

In food products, in confectionery. As a humectant, like glycerol, to hold moisture and to prevent drying out. In brewing.

Invert Sugar is a sweetener that is a mixture of equal weights of dextrose (glucose) and levulose (fructose). It is more soluble than sucrose and has higher moisture-retaining properties because of the fructose content. It resists crystallization. It is used in candy and icings because it is sweeter, more soluble, and crystallizes less readily than sucrose.

Formulations：

INVERT SUGAR: INJECTION, 5%; 250 ML, 500 ML AND 1 L BOTTLES. INJECTION, 10%; 250 ML, 500 ML AND 1 L BOTTLES. INJECTION, 20%; 100 ML BOTTLES. INJECTION, 5% WITH SODIUM CHLORIDE 0.9%; 250 ML, 500 ML AND 1 L BOTTLES.|SUCROSE IN THE 66.7% WT/WT SOLN /OF INVERT SYRUP/ MUST BE AT LEAST 95% INVERTED.|It absorbs water readily, and is usually only handled as a syrup.|Commercial invert sugar, a solution of dextrose and fructose of about 77% concn, is sometimes called artificial honey because its composition is similar to that of the natural product.

Manufacturing Info：

Sugar, invert: ACTIVE|A mixture of about 50% glucose (dextrose) and 50% fructose (levulose) obtained by hydrolysis of sucrose. Hydrolysis of the sucrose may be carried out with acids or enzymes.|IT IS A SUBSTANCE WHICH MIGRATES TO FOOD FROM PACKAGING MATERIALS.|Honey is mostly invert sugar. Due to the levulose /50% of composition of invert sugar/, it is somewhat sweeter than sucrose.|Invert sugar is widely used ... because it is sweeter than sucrose and begins to crystallize (harden) at much higher concentrations than glucose or sucrose syrups

Analytic Methods：

AOAC Method 920.190. Sugars (Reducing) in Maple Products as Invert Sugar.|AOAC Method 970.38. Invert Sugar in Molasses.|AOAC Method 963.36. Refractive indices of invert sugar solutions.|AOAC Method 940.39. Hammond table for calculating glucose, fructose, and invert sugar and lactose alone and in the presence of sucrose ...

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:360.31
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:10
Exact Mass:360.12677620
Monoisotopic Mass:360.12677620
Topological Polar Surface Area:236
Heavy Atom Count:24
Complexity:285
Defined Atom Stereocenter Count:7
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

No specific pharmacological effects mentioned

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Invert Sugar for Injection
Specifications	Fructose 6.25g and glucose 6.25g
Manufacturer	Hubei Hepu Pharmaceutical Co., Ltd.