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Furafylline

Furafylline structure

CAS No:
80288-49-9
Formula:
C12H12N4O3
Chemical Name:
Furafylline
Synonyms:
1H-Purine-2,6-dione,3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl-;1H-Purine-2,6-dione,3-(2-furanylmethyl)-3,7-dihydro-1,8-dimethyl-;3-(2-Furanylmethyl)-3,9-dihydro-1,8-dimethyl-1H-purine-2,6-dione;Furafylline
Categories:
Active Pharmaceutical Ingredients > Inhibitor Drugs

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Description

Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM.

Furafylline is an oxopurine.

Furafylline Basic Attributes

Molecular Weight：

260.25

Exact Mass：

260.25

UNII：

C2087G0XX3

DSSTox ID：

DTXSID2045153

HScode：

2939590000

Characteristics

PSA：

82.4

XLogP3：

0.6

Density：

1.4±0.1 g/cm3

Boiling Point：

504.8°C at 760 mmHg

Flash Point：

282.6±32.9 °C

Refractive Index：

1.637

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH：

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inhibitors.)

Metabolism/Metabolites：

Furafylline has known human metabolites that include 3-[(furan-2-yl)methyl]-8-hydroxy-1-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione.

MeSH Entry Terms：

1,8-dimethyl-3-(2'-furfuryl)-1H-purine-2,6-dione

Furafylline Use and Manufacturing

inhibitor

Computed Properties

Molecular Weight:260.25
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:260.09094026
Monoisotopic Mass:260.09094026
Topological Polar Surface Area:82.4
Heavy Atom Count:19
Complexity:402
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Furafylline

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE

CAS No.: 80288-49-9

Content: 99.00%

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