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Selumetinib

Selumetinib structure

CAS No:
606143-52-6
Formula:
C17H15BrClFN4O3
Chemical Name:
Selumetinib
Synonyms:
1H-Benzimidazole-6-carboxamide,5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-;5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;ARRY 142886;AZD 6244;Selumetinib;NSC 741O78;G 00039805;6-(4-Bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide;Koselugo;AZD6244;AZD-6244;865610-79-3
Categories:
Active Pharmaceutical Ingredients > Inhibitor Drugs

Description

ChEBI: A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-chlorophenyl)amino, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectiv ly. It is a MEK1 and MEK2 inhibitor.

Selumetinib Basic Attributes

Molecular Weight：

457.685

Exact Mass：

457.68

HScode：

29349990

Characteristics

PSA：

88.4

XLogP3：

3.6

Appearance：

White or pale white solid.

Density：

1.69

Storage Conditions：

Powder stores in -20ºC directly, which is effective for a period of 2 years.

Safety Information

Precautionary statement(s)：

P201, P202, P260, P261, P272, P273, P280, P281, P302+P352, P305+P351+P338, P308+P313, P310, P314, P321, P333+P313, P363, P391, P405, P501

Hazard Statements：

H317

Selumetinib Use and Manufacturing

It is a tight-binding, uncompetitive inhibitor of mitogen-activated protein kinase kinases (MEK) 1 and 2 currently in clinical development.

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