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Bunazosin

Bunazosin structure

CAS No:
80755-51-7
Formula:
C19H27N5O3
Chemical Name:
Bunazosin
Synonyms:
1-Butanone,1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-1H-1,4-diazepin-1-yl]-;1H-1,4-Diazepine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-4-(1-oxobutyl)-;1-[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-1H-1,4-diazepin-1-yl]-1-butanone;Bunazosin;E 1015;1-[4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl]butan-1-one
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

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Description

Bunazosin is a member of quinazolines.|Bunazosin has been used in trials studying the treatment of High Blood Pressure.

Bunazosin Basic Attributes

Molecular Weight：

373.45

Exact Mass：

373.45

UNII：

9UUW4V7G2H

DSSTox ID：

DTXSID7022700

Characteristics

PSA：

93.8

XLogP3：

2.65210

Density：

1.221

Boiling Point：

620.6ºC at 760 mmHg

Drug Information

MeSH：

Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)

MeSH Entry Terms：

4-amino-2-(4-butanoylhexahydro-1H-1,4-diazepin-1-yl)-6,7-dimethoxyquinazoline HCl

Bunazosin Use and Manufacturing

Bunazosin is an α-1 adrenergic receptor antagonist that acts as an anti-cancer and anti-glaucoma drug.

Computed Properties

Molecular Weight:373.4
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:373.21138974
Monoisotopic Mass:373.21138974
Topological Polar Surface Area:93.8
Heavy Atom Count:27
Complexity:494
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes