Vesnarinone
-
Vesnarinone
structure -
-
CAS No:
81840-15-5
-
Formula:
C22H25N3O4
-
Chemical Name:
Vesnarinone
-
Synonyms:
2(1H)-Quinolinone,6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-;Piperazine,1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)-;6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone;OPC 8212;Vesnarinone;Arkin;Pieranometazine
-
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
-
CAS No:
Description
Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux.IC50 value: 1.1 μM (for HERG current)Target: PDE3in vitro: HERG current is inhibited by Vesnarinone with an IC50 of 1.1 μM, whereas KvLQT1/minK current is not significantly depressed by Vesnarinone even at 30 μM. The IC50 value for Vesnarinone inhibition of HERG channels is 1 μM. The IC50 for Vesnar
Arkin (TN) is an organic molecular entity.|Vesnarinone has been used in trials studying the treatment of HIV Infections and Sarcoma, Kaposi.|Vesnarinone is a cardiotonic quinolinone derivative, that suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin dependent kinase activity in p53-mediated cell cycle arrest. (NCI)
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)|Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases. (See all compounds classified as Phosphodiesterase Inhibitors.)|Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)|Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)
3,4-dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2-1H-quinolinone
Vesnarinone Use and Manufacturing
It can increase the contractility without increasing the heart rhythm, so it causes less increase in myocardial oxygen consumption. Used for mild to moderate chronic heart failure.
Computed Properties
Molecular Weight:395.5
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:395.18450629
Monoisotopic Mass:395.18450629
Topological Polar Surface Area:71.1
Heavy Atom Count:29
Complexity:593
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Learn More Other Chemicals
-
Dronedarone
141626-36-0
-
Zofenopril calcium
81938-43-4
-
3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
86499-96-9
-
Tirofiban hydrochloride monohydrate Formula
150915-40-5
-
Saxagliptin Formula
361442-04-8
-
Dapoxetine Formula
119356-77-3
-
Fasudil Structure
103745-39-7
-
3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-[(1-oxobutoxy)methyl] ester Structure
167221-71-8
-
What is 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone
272778-12-8
-
What is (-)-Oxyfedrine
15687-41-9