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Pentopril

Pentopril structure

CAS No:
82924-03-6
Formula:
C18H23NO5
Chemical Name:
Pentopril
Synonyms:
Pentopril;CGS 13945;(2S)-1-[(2R,4R)-4-(Ethoxycarbonyl)-2-methyl-1-oxopentyl]indoline-2-carboxylic acid;(2S)-1-[(2R,4R)-1,5-Dioxo-2,4-dimethyl-5-ethoxypentyl]-2,3-dihydro-1H-indole-2α-carboxylic acid;1H-Indole-1-pentanoic acid, 2-carboxy-2,3-dihydro-alpha,gamma-dimethyl -delta-oxo-, ethyl ester, (2S-(1(alphaS*,gammaS*),2R*))-
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Pentopril is a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, pentopril is hydrolyzed into its active form pentoprilat, which competitively inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Pentoprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

Pentopril Basic Attributes

Molecular Weight：

333.382

Exact Mass：

333.15800

UNII：

Z99269057A

NCI Thesaurus Code：

C72909

HScode：

2933990090

Characteristics

PSA：

83.9

XLogP3：

2.31930

Density：

1.221g/cm3

Boiling Point：

562.1ºC at 760 mmHg

Flash Point：

293.8ºC

Refractive Index：

1.549

Drug Information

MeSH Entry Terms：

1-(4-(ethoxycarbonyl)-2-methylpentanoyl)-2,3-dihydroindole-2-carboxylic acid

Pentopril Use and Manufacturing

Enzyme inhibitor (angiotensin-converting).

Computed Properties

Molecular Weight:333.4
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:333.15762283
Monoisotopic Mass:333.15762283
Topological Polar Surface Area:83.9
Heavy Atom Count:24
Complexity:492
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes