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Accelerator CZ

Accelerator CZ structure

CAS No:
95-33-0
Formula:
C13H16N2S2
Chemical Name:
Accelerator CZ
Synonyms:
2-Benzothiazolesulfenamide,N-cyclohexyl-;N-Cyclohexyl-2-benzothiazolesulfenamide;Conac A;Curax;Delac S;Conac S;Royal CBTS;Santocure;Sulfenamide Ts;N-Cyclohexylbenzothiazolesulfenamide;Ekagom CBS;Vulkacit CZ;Vulcafor CBS;Sulfenax CB;Thiohexam;Sulfenax;Sulfenax CB 30;Rhodifax 16;Accelerator CZ;N-Cyclohexylbenzothiazole-2-sulphenamide;2-(Cyclohexylaminothio)benzothiazole;Benzothiazyl-2-cyclohexylsulfenamide;CBS;Nocceler CZ;Vulkacit C;Soxinol CZ;Sulfenax CB/K;Vulkacit CZ/K;Vulkacit CZ/C;Pennac CBS;Accicure HBS;N-Cyclohexyl-2-benzothiazolylsulphenamide;Sanceler CM-PO;Vulcafor HBS;Sanceler CM;Nocceler CZ-P;CBTS;N-Cyclohexyl-2-benzothiazolylsulfenamide;N-Cyclohexyl-2-benzothiazylsulfenamide;Nocceler CZ-G;Rhenogran CBS;2-Benzothiazolesulfenic acid N-cyclohexylamide;Accel CZ;Durax;Vulkafil ZN 94TT02;Sanceler CZ-P;Vulkacit CZ/EG-C;Sanceler CM-G;CBS (accelerator);CZ-G;Santocure CBS;NSC 4809;Banac CBS;Vulkacit CZ/EG;Vulkacit CZ/CV;Perkacit CBS;Sanceler CZ-G;Rhenogran CBS 80;Accelerator CM;CZ;CBS 80;Accelerator CBS;CZ Vulcanizer;Nocceler CZ-R;CZ 80;Oricel CZ;51540-81-9;75301-39-2;108251-59-8;156014-54-9;929698-33-9;2087514-33-6
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

DryPowder; OtherSolid; PelletsLargeCrystals

Thiohexam is a rubber cure accelerator. It is also a known allergen and dermatological sensitizer. Sensitivity to Thiohexam may be identified with a clinical patch test.|N-cyclohexyl-2-benzothiazosulfenamide is a Standardized Chemical Allergen. The physiologic effect of n-cyclohexyl-2-benzothiazosulfenamide is by means of Increased Histamine Release, and Cell-mediated Immunity.

Accelerator CZ Basic Attributes

Molecular Weight：

264.41

Exact Mass：

264.41

EC Number：

202-411-2

UNII：

UCA53G94EV

NSC Number：

4809

DSSTox ID：

DTXSID5020360

Color/Form：

CREAM-COLORED POWDER

HScode：

2934999090

Characteristics

PSA：

78.5

XLogP3：

5.32

Appearance：

DryPowder; OtherSolid; PelletsLargeCrystals

Density：

1.27 g/cm³

Melting Point：

93-100 °C

Boiling Point：

410.4±28.0 °C at 760 mmHg

Flash Point：

202.0±24.0 °C

Refractive Index：

1.665

Water Solubility：

INSOL IN WATER; SOL IN BENZENE

Toxicity：

LD50 oral in rat: 5300mg/kg

Safety Information

Packing level：

III

Hazard category：

Transport codes：

3077

hazard class code：

36/37/38-50/53-43

safety instructions：

26-36/37/39-61-60-37-24

RTECS Number：

DL6250000

Marks：

Xi,N

Precautionary statement(s)：

P261, P272, P273, P280, P302+P352, P321, P333+P313, P363, P391, P501

Hazard Statements：

H317

Disposal Methods：

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Special Reports：

Scansetti G; Ergonomics and Health in Modern Offices. Grandjean E (ed), Taylor & Francis (1984). Toxic agents emitted from office machines and materials.

GHS Classification：

|Warning|H317: May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P273, P280, P302+P352, P321, P333+P313, P363, P391, and P501|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|Aggregated GHS information provided by 263 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|P201, P202, P260, P261, P264, P272, P280, P281, P302+P352, P305+P351+P338, P308+P313, P314, P321, P333+P313, P337+P313, P363, P405, and P501

Drug Information

Drug Indication：

Thiohexam is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years of age and older.

Human Toxicity Excerpts：

CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF OCCUPATIONAL DERMATOSES CAUSED BY SULFENAMIDE C.|SUMMARY TOXICITY STATEMENT: ACUTE...MODERATE VIA ORAL ROUTE. MODERATE= MAY CAUSE REVERSIBLE OR IRREVERSIBLE CHANGES TO EXPOSED TISSUE, NOT PERMANENT INJURY OR DEATH; CAN CAUSE CONSIDERABLE DISCOMFORT.

MeSH Entry Terms：

N-cyclohexyl-2-benzothiazolesulfenamide

Accelerator CZ Use and Manufacturing

Methods of Manufacturing

It is derived from the reaction of accelerator M (2-thiol benzothiazole) with cyclohexylamine. The accelerator M is mixed with the cyclohexylamine aqueous solution, and sodium hypochlorite is added dropwise under stirring to obtain a crude product. The solid material is separated, washed with water to neutrality, and dried below 75°C to obtain a finished product. Raw material consumption (kg/t) accelerator M (95%) 745 cyclohexylamine (95%) 500

Uses

CZ is a highly active after-effect accelerator with excellent scorch resistance, safe processing and short curing time. The promotion effect is strong when the vulcanization temperature is above 138℃. Often cooperate with WIlling TMTD, WIlling DPG or other alkaline accelerator to cooperate with the second accelerator. Alkaline accelerators such as thiurams and dithiocarbamates can enhance their activity. It is mainly used to manufacture industrial rubber products such as tires, hoses, rubber shoes, cables and so on.

Accerlerator

Plastic and rubber products not covered elsewhere

Production

10,000,000 - 50,000,000 lb|(1972) 4.00X10+9 GRAMS|(1975) 1.15X10+9 GRAMS

Consumption Patterns：

ESSENTIALLY 100% AS RUBBER ACCELERATOR

Manufacturing Info：

Recycling|2-Benzothiazolesulfenamide, N-cyclohexyl-: ACTIVE

Computed Properties

Molecular Weight:264.4
XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:264.07549087
Monoisotopic Mass:264.07549087
Topological Polar Surface Area:78.5
Heavy Atom Count:17
Complexity:244
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Cyclohexylamine

Cyclohexanone

2-Butoxyethanol

Sodium hydroxide

Aniline

Sodium hypochlorite

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