1,2,3-Trichloro-1-propene

145.41

145.41

202-487-7

2903299090

0.00000

2.54420

1,2,3-trichloropropene appears as an amber liquid. May be absorbed through the skin. Vapors are heavier than air. Contact with vapors or liquid may cause burns or irritation.

1.412 g/cm³ @ Temp: 20 °C

-30°C (estimate)

142 °C

82°C

1.487

VERY SOL IN CHLOROFORM

4.40 mmHg

LD50 orl-rat: 616 mg/kg UCDS** 5/4/60

Freezing point= -78 °C|Pounds per gallon= 11.65 at 20 °C.|vapor pressure = 4-7 torr, at 20 °C.

III

6.1(b)

2810

20/21/22-36/37/38

26-36/37/39

UD2450000

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personnel protection: ... Wear appropriate chemical protective clothing. Wear positive pressure self-contained breathing apparatus. ...

MODERATE WHEN EXPOSED TO HEAT, FLAMES (SPARKS) OR POWERFUL OXIDIZERS

If material on fire or involved in fire: Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources.

If material not on fire and not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Keep sparks, flames, and other sources of ignition away. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.|Personnel protection: Keep upwind. Avoid breathing vapors. ... Avoid breathing fumes from burning material.

1,2,3-Trichloro-1-propene's production and use as a chemical intermediate(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 130(SRC), determined from a structure estimation method(2), indicates that 1,2,3-trichloro-1-propene will have high mobility in soil(SRC). Volatilization of 1,2,3-trichloro-1-propene may be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 1.8X10-2 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Volatilization from dry soil surfaces(SRC) may occur based on a measured vapor pressure of 4-7 mm Hg(4).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 130(SRC), determined from a structure estimation method(2), indicates that 1,2,3-trichloro-1-propene should not adsorb to suspended solids and sediment in water(SRC). 1,2,3-Trichloro-1-propene is expected to volatilize from water surfaces(1,SRC) based on an estimated Henry's Law constant of 1.8X10-2 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Estimated half-lives for a model river and model lake are 4 hours and 5 days, respectively(1,SRC). Measured half-lives for 1,2,3-trichloro-1-propene in dilute (1 ppm, depth of solution=6.5 cm) aqueous solution ranged from 45.1 to 45.2 minutes(4). According to a classification scheme(6), an estimated BCF value of 80(1,SRC), from an estimated log Kow(5,SRC), suggests that bioconcentration in aquatic organisms is moderate, not high(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,2,3-trichloro-1-propene, which has a measured vapor pressure of 4-7 mm Hg at 20 °C(2,SRC), will exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,2,3-trichloro-1-propene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 5 days(3,SRC).

The rate constant for the vapor-phase reaction of 1,2,3-trichloro-1-propene with photochemically-produced hydroxyl radicals has been estimated as 3.3X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 5 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC).

An estimated BCF value of 80 was calculated for 1,2,3-trichloro-1-propene(SRC), using an estimated log Kow of 2.78(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is moderate, not high(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 1,2,3-trichloro-1-propene can be estimated to be about 130(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that 1,2,3-trichloro-1-propene has high mobility in soil(SRC).

The Henry's Law constant for 1,2,3-trichloro-1-propene is estimated as 1.8X10-2 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that 1,2,3-trichloro-1-propene will volatilize rapidly from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 4 hours(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 5 days(2,SRC). Measured half-lives for 1,2,3-trichloro-1-propene in dilute (1 ppm, depth of solution= 6.5 cm) aqueous solution ranged from 45.1 to 45.2 minutes(3). The time required for 50 and 90% evaporation of 1,2,3-trichloro-1-propene from a dilute aqueous solution was 49 and >140 minutes, respectively(4). 1,2,3-Trichloro-1-propene's values for vapor pressure, 4-7 mm Hg(5) and Henry's Law constant(1,SRC) indicate that volatilization from dry and moist soil surfaces may occur(SRC).

Occupational exposure may be through inhalation and dermal contact with this compound at workplaces where 1,2,3-trichloro-1-propene is produced or used. (SRC)

In the presence of S9 mix all allylic chloropropenes tested exert considerable indirect mutagenic activity which is most pronounced for 1,2,3-trichloropropene. Lower as well as higher chlorinated derivatives are clearly less mutagenic. Longer than standard incubation time (120 min instead of 20 min) at 37 °C always leads to an incr in mutagenic activity. An incr in concn of rat liver homogenate fraction (S9) in the metabolizing system (S9 mix) enhances mutagenicity only for 1,3-dichloropropene, 2,3-dichloro-1-propene and for the cis isomer of 1,1,2,3-tetrachloro-2-propene. According to the effects of the enzyme inhibitors SKF525, 1,1,1-trichloropropene-2,3-oxide and cyanamide the allylic chloropropenes fall into 3 groups distinguished by their mode of metabolic activation by S9 mix: (a) allyl chloride and 1,3-dichloropropene are hydrolyzed to the corresponding allylic alcohols which can be oxidized to the respective acroleins (hydrolytic-oxidative pathway); (b) 2,3-dichloro-1-propene, 1,1,2,3-tetrachloro-2-propene and hexachloropropene are epoxidized in the C=C double bond, giving rise to reactive epoxides (epoxidative pathway); (c) only 1,2,3-trichloropropene is obviously activated by both these alternative metabolic pathways. Structural parameters like chloro substitution of the central C atom of the C=C-C sequence and substituent induced polarization of the C=C double bond as well as cis/trans isomerism might be responsible for different substrate properties for the enzymes involved in allylic chloropropene metabolism, thus determining different degrees of activation by either one or both pathways.

1-Propene, 1,2,3-trichloro-: ACTIVE