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Clopenthixol

Clopenthixol structure

CAS No:
982-24-1
Formula:
C22H25ClN2OS
Chemical Name:
Clopenthixol
Synonyms:
1-Piperazineethanol,4-[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]-;1-Piperazineethanol,4-[3-(2-chlorothioxanthen-9-ylidene)propyl]-;9H-Thioxanthene,1-piperazineethanol deriv.;4-[3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl]-1-piperazineethanol;4-[3-(2-Chlorothioxanthen-9-ylidene)propyl]-1-piperazineethanol;2-(4-[3-(2-Chloro-9-thioxanthenylidene)propyl]-1-piperazinyl)ethanol;Clopenthixol;Sordinol;Chlorpenthixol;NSC 64087;2-(4-(3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl)piperazin-1-yl)ethanol
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

ChEBI: A thioxanthene derivative having a chloro substituent at the 2-position and an alkylidene group at the 10-position with undefined double bond stereochemistry.

A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

Clopenthixol Basic Attributes

Molecular Weight：

400.971

Exact Mass：

400.96

EC Number：

213-566-0

DSSTox ID：

DTXSID9048223

ATC Code：

N - Nervous system

HScode：

2934999090

Characteristics

PSA：

XLogP3：

4.11210

Density：

1.289g/cm3

Boiling Point：

577.4ºC at 760mmHg

Flash Point：

303ºC

Collision Cross Section：

194 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Drug Information

MeSH：

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)|Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

MeSH Entry Terms：

alpha Clopenthixol

Clopenthixol Use and Manufacturing

Uses

It is the cis-isomer of clopiezide. It is used for the state of anxiety and confusion caused by senile dementia, acute and chronic schizophrenia, mania, and extreme excitability.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:401.0
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:400.1376123
Monoisotopic Mass:400.1376123
Topological Polar Surface Area:52
Heavy Atom Count:27
Complexity:509
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes