Pepsin A
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Pepsin A
structure -
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CAS No:
9001-75-6
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Chemical Name:
Pepsin A
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Synonyms:
Pepsin A;E.C. 3.4.4.1;E.C. 3.4.23.1;Pepsin;Pepsin 3;Puerzym;Pepsin P389P;R 5500;Pepsibio 1:10,000;Pepsibio;P7012 1G;8048-15-5;9001-76-7
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CAS No:
Description
Pepsin is a kind of endopeptidase that breaks down proteins into smaller peptides (that is, a protease). It is biologically produced in the animal stomach and is one of the main digestive enzymes in the digestive systems of humans and many other animals, where it helps digest the proteins in food. Pepsin is an important acidic protease that is widely applied in the hydrolysis of proteins. It is used in collagen extraction
[1-3]
in gelatin extraction
[4]
as a rennet substitute<
Characteristics
slightly beige powder
1.15 g/cm3
soluble in water and dilute aqueous buffers;10 mM HCl: soluble 1.0mg/mL, clear to faintly turbid, colorless
2-8°C
D26 -64.5° (water pH 4.6)
Safety Information
NONH for all modes of transport
1
36/37/38-42-42/43
22-24-26-36/37-36-45
SC6132000
Xn
Stable. Incompatible with strong bases, alkalies, metallic salts, alcohols.
P261-P305 + P351 + P338-P342 + P311
H315-H319-H334-H335
Pepsin A Use and Manufacturing
Take 200kg of porcine gastric mucosa by autolysis and filtration, add it to a jacketed pot containing 100L of water and 3.8L of hydrochloric acid (CP) under stirring. When heated to 500, stir quickly to make the acidity uniform and keep the temperature at 45～480 C, make it digest for 3～4h, get from solution. Filter with gauze to remove undigested tissue protein residues, and collect the filtrate. Porcine gastric mucosa H2O; HCl; 450; 3h→auto-dissolve, filter and degrease from the solution, remove impurities, cool the filtrate to room temperature, add 15%-20% chloroform or ether under constant stirring, and transfer the solution to In the precipitation degreasing device, let it stand for 1 to 2 days to completely precipitate the impurities, separate the clear liquid, and discard the precipitate. Get defatted enzyme solution. From the solution chloroform or ether → degreasing; concentrating and drying the supernatant to remove impurities to take the clear enzyme solution, concentrating at less than 400 under reduced pressure to about 1/4 of the original volume, and then vacuum drying the concentrated enzyme solution, ball milling through 80~ Sieve with 100 meshes to obtain pepsin powder. The supernatant is below 400C → concentrated and dried pepsin finished product containing sugar pepsin The finished product pepsin is added with lactose, glucose or sucrose and diluted to obtain sugar pepsin. Pepsin finished product lactose, grape bran or sucrose → diluted sugar-containing pepsin preparation
This product can decompose protein coagulated by stomach acid into peptone, but cannot further decompose it into amino acids. Its digestive power is the strongest with 0.2% to 0.4% hydrochloric acid (PH=1.6 to 1.8).
Drug Function and Efficacy
Extract from the above information
Registered Holders
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Sichuan Shangshantang Pharmaceutical Co., Ltd.
Active
China
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Jiangsu Zetai Pharmaceutical Co., Ltd.
Active
China
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Gansu Xinyi Tiansen Pharmaceutical Co., Ltd.
Active
China
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