 Home > Encyclopedia > URICASE

URICASE

URICASE structure

CAS No:
9002-12-4
Formula:
C18H26N5O14P
Chemical Name:
URICASE
Synonyms:
EC 1.7.3.3;EC: 1.7.3.3;IUB: 1.7.3.3;URATE: O2 OXIDOREDUCTASE;URATE OXIDASE;URATE: OXIDOREDUCTASE;URATE: OXYGEN OXIDOREDUCTASE;URATE: OXYGEN OXOREDUCTASE
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

White powder

Mice deficient in uricase develop uric acid nephropathy and diabetes insipidus which can be mitigated with recombinant uricase treatment.

Urate Oxidase Recombinant produced in E.Coli is a tetrameric, non-glycosylated polypeptide chain containing 302 amino acids, having a molecular formula of C1523H2383N417O462S7 and a molecular mass of 34,247 Dalton.The cDNA coding for urate-oxidase was cloned from a strain of Aspergillus flavus . The monomer protein has no intra- or inter-disulfide bridges.

Escherichia Coli

URICASE Basic Attributes

Molecular Weight：

567.397901

Exact Mass：

567.121399

EC Number：

232-655-5

TSCA：

TSCA listed

DSSTox ID：

DTXSID8046826

Color/Form：

White to off-white

HScode：

35079090

Characteristics

PSA：

255

Appearance：

lyophilized powder

Water Solubility：

Hardly soluble in water, slightly soluble in buffer alkaline solution.

Storage Conditions：

−20°C

Critical Temperature & Pressure：

-20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

RTECS Number：

YU7100000

Precautionary statement(s)：

P201-P261-P280-P284-P304 + P340-P308 + P313

Hazard Statements：

H334-H360FD

GHS Classification：

|Danger|H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]|P261, P285, P304+P341, P342+P311, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory.

URICASE Use and Manufacturing

Methods of Manufacturing

Using yeast as raw material, the sodium phosphate is extracted and then graded with ammonium sulfate, and then the product is obtained by dialysis, column chromatography and ammonium sulfate recrystallization.

Uses

In the determination of serum and urine uric acid.

Uricase is very important for the determination of uric acid in biological fluids. Uricase is an important medical enzyme which can be used to determine urate in clinical analysis. The enzyme Urate oxidase (UO) catalyzes the oxidation of uric acid to 5-hydroxyisourate.

Uricase fromArthrobacter globiformishas been used for coating the electrodes in - biosensor fabrication for the detection of uric acid in urine samples. It has also been used for analysing the effect of Zn, Cu, Mg, and Mn ions on uricase.

Manufacturing Info：

Urate oxidase: ACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).

Computed Properties

Molecular Weight:567.4
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:8
Exact Mass:567.12138752
Monoisotopic Mass:567.12138752
Topological Polar Surface Area:255
Heavy Atom Count:38
Complexity:1070
Undefined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of URICASE

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Oxidase urate

CAS No.: 9002-12-4

Content: 99.00%

Inquiry
LEADER BIOCHEMICAL GROUP Contact Supplier

CN
8 YRS

Business licensed Certified factory

Manufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances Chemicals

Urate oxidase CAS 9002-12-4 for Scientific Research Chemical Reagents Use only

CAS No.: 9002-12-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Creative Enzymes Contact Supplier

US
6 YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

Uricase, Recombinant

CAS No.: 9002-12-4

Content: 90%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

UAO 99% white powder kanbei

CAS No.: 9002-12-4

Grade: Industrial Grade

Content: 99%

Inquiry
Hebei Longbang Technology Co., Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of chemical

CAS 9002-12-4 URICASE Detection of uric acid in serum and urine by enzyme. Biochemical research

CAS No.: 9002-12-4

Grade: Chemical Grade

Content: 99%

Inquiry