Pancreatic trypsin inhibitor
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Pancreatic trypsin inhibitor
structure -
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CAS No:
9087-70-1
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Chemical Name:
Pancreatic trypsin inhibitor
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Synonyms:
Trypsin inhibitor,pancreatic basic;Pancreatic basic trypsin inhibitor;Basic pancreatic trypsin inhibitor;Pancreatic trypsin inhibitor;Pancreatic trypsin inhibitor (Kunitz);Kunitz pancreatic trypsin inhibitor;Antilysin;Antilysine;Aprotinin;Trasylol;Trypsin-kallikrein inhibitor (Kunitz);Kallikrein-trypsin inactivator;Trypsin inhibitor,Trasylol;Kunitz trypsin inhibitor;Zymofren;Triazinin;Bovine pancreatic trypsin inhibitor;BPTI;Kunitz-type inhibitor;Kunitz-type proteinase inhibitor;Kunitz-type trypsin inhibitor;Bovine basic pancreatic trypsin inhibitor;BPTI trypsin inhibitor;Kunitz protease inhibitor;Bovine trypsin inhibitor;Trasuylol;Onquinin;Antikrein;RP 9921;Fosten;Bayer A 128;Kiker 52G;Trazinin;Kir Richter;Repulson;Protease inhibitor,Kunitz type;Aprostat;Antiprovir;9004-04-0;9039-77-4;11005-72-4;11132-77-7;39283-52-8;69431-34-1
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CAS No:
Description
Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively.
Characteristics
2820
0.00000
white; lyophilized powder
Freely soluble in water and in aqueous buffers of low ionic strength;glycerol: soluble 3mg/mL, clear, colorless (equilibration buffer containing 5% glycerol)
2-8°C
LD50 i.v. in mice: 2500000 kallikrein inhibitor units/kg (Trautschold)
Safety Information
NONH for all modes of transport
1
42/43-36/37/38-20/21/22
22-45-36/37-36-26
YN5080000
Xn,Xi
Stable. Incompatible with strong oxidizing agents.
Pancreatic trypsin inhibitor Use and Manufacturing
Aprotinin is largely used as an inhibitor of trypsin. Proteolytic inhibitor in radioimmunoassays of polypeptide hormones.Peptidase inhibitors. It can inhibit trypsin, chymotrypsin and fibrinolytic enzyme. Used for fibrinolysis, acute pancreatitis and pancreatic necrosis.
Drug Function and Efficacy
Aprotinin is a broad-spectrum protease inhibitor that can be used to regulate the body's inflammatory response (SIR) caused by extracorporeal circulation (CPB) surgery. Through its multiple regulatory inhibitory effects (such as vasodilators, plasmin), it can reduce the inflammatory response, fibrinolytic response and thrombin production. Aprotinin can inhibit the release of inflammatory cytokines, maintain the balance of glycoproteins, reduce the loss of platelet glycoproteins (such as GpⅠbGpⅡb/Ⅲa), and prevent the expression of inflammatory adhesive glycoproteins in granulocytes (such as CDⅡb). Its role in CPB also includes reducing inflammatory responses and reducing the need for allogeneic blood transfusions.
Registered Holders
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Hangzhou Ausia Biological Technology Co., Ltd.
Active
China
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Jiuquan Dadeli Pharmaceutical Co., Ltd.
Active
China
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Techpool BIO-PHARMA Co., Ltd.
Active
China
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