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1,3-Dichloro-2-nitrobenzene

1,3-Dichloro-2-nitrobenzene structure

CAS No:
601-88-7
Formula:
C6H3Cl2NO2
Chemical Name:
1,3-Dichloro-2-nitrobenzene
Synonyms:
Benzene,1,3-dichloro-2-nitro-;1,3-Dichloro-2-nitrobenzene;2,6-Dichloronitrobenzene;2,6-Dichloro-1-nitrobenzene
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

CRYSTALS.

1,3-Dichloro-2-nitrobenzene Basic Attributes

Molecular Weight：

192

Exact Mass：

192.00

EC Number：

210-009-3

ICSC Number：

0253

UN Number：

1578

DSSTox ID：

DTXSID00208847

HScode：

2904909090

Characteristics

PSA：

45.8

XLogP3：

Appearance：

CRYSTALS.

Density：

1.6 g/cm³

Melting Point：

72.5 °C

Boiling Point：

130 °C @ Press: 8.3 Torr

Flash Point：

118.9ºC

Refractive Index：

1.595

Vapor Density：

Relative vapour density (air = 1): 6.6

Safety Information

Transport codes：

1578

Marks：

T: Toxic;

Storage features：

Separated from bases and strong oxidants.

Precautionary statement(s)：

P273, P280, P302+P352, P312, P322, P363, P501

Hazard Statements：

H312

Fire Hazards：

Combustible.

GHS Classification：

|Warning|H312 (89.47%): Harmful in contact with skin [Warning Acute toxicity, dermal]|P273, P280, P302+P352, P312, P322, P363, and P501|Aggregated GHS information provided by 38 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fire Fighting：

Use powder, alcohol-resistant foam, water spray, carbon dioxide.

Spillage Disposal：

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

Safe Storage：

Separated from bases and strong oxidants.

Inhalation Risk：

A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.

Fire Prevention：

NO open flames.

Exposure Prevention：

PREVENT DISPERSION OF DUST!

Inhalation Prevention：

Use ventilation (not if powder).

Skin Prevention：

Protective gloves.

Eye Prevention：

Wear safety spectacles.

Drug Information

First Aid：

Fresh air, rest.

Rinse and then wash skin with water and soap.

Rinse with plenty of water (remove contact lenses if easily possible).

Symptoms：

Cough.

Redness.

1,3-Dichloro-2-nitrobenzene Use and Manufacturing

1.32 g (4.0 mmol) of sodium tungstate dihydrate and 4.0 g (40 mmol) of concentrated sulfuric acid were added to a solution of 16.2 g (100 mmol) of 2, 6-dichloroaniline in 120 ml of methanol, and the mixture was heated to 40° C. 30 ml (291 mmol) of a 30percent hydrogen peroxide solution was added dropwise over 10 hours. 2.1.5. 1, 3-Dichloro-2-nitrobenzene [4] A solution of 2, 6-dichloroaniline (8.10 g, 50.0 mmol) in dichloromethane (200 mL) was cooledto 0 °C before a solution of 3-chloroperbenzoic acid (24.6 g, 100 mmol) in dichloromethane(250 mL) was added dropwise to the reaction mixture over a period of 1.5 h at 0 °C.Thereafter the solution was stirred for 2 h at room temperature before it was diluted withdichloromethane (250 mL). The reaction mixture was washed two times with an aqueoussodium thiosulfate solution (2 wt percent, 2 × 100 mL), with an aqueous sodium bicarbonatesolution (4 × 50 mL), and finally with deionized water (200 mL). The organic layer was driedwith magnesium sulfate and the solvent was removed in vacuo. The residue was suspendedin 40 mL n-hexane and irradiated by ultrasound for 5 min, filtered off, washed with n-hexane(2 × 20 mL) to give 1, 3-dichloro-2-nitrobenzene (6.63 g, 37.7 mmol, 75percent) as a beige solid

Computed Properties

Molecular Weight:192.00
XLogP3:3
Hydrogen Bond Acceptor Count:2
Exact Mass:190.9540837
Monoisotopic Mass:190.9540837
Topological Polar Surface Area:45.8
Heavy Atom Count:11
Complexity:149
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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2,6-Dichloronitrobenzene

CAS No.: 601-88-7

Content: 99.00%

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NANTONG REFORM PETRO-CHEMICAL CO.,LTD Contact Supplier

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2,6-Dichloronitrobenzene

CAS No.: 601-88-7

Grade: Industrial Grade

Content: 99%

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Guide of 1,3-Dichloro-2-nitrobenzene

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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1,3-Dichloro-2-nitrobenzene

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