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Dibazole

Dibazole structure

CAS No:
621-72-7
Formula:
C14H12N2
Chemical Name:
Dibazole
Synonyms:
1H-Benzimidazole,2-(phenylmethyl)-;Benzimidazole,2-benzyl-;2-(Phenylmethyl)-1H-benzimidazole;Bendazol;2-Benzylbenzimidazole;Dibasol;Dibazol;Dibazole;Tromasedan;Bendazole;NSC 60020;NSC 631632;2-Benzyl-1H-benzimidazole;2-Benzyl-1H-benzo[d]imidazole;2-Benzyl-1H-1,3-benzodiazole;2-Benzyl-1H-benzoimidazole;102389-81-1
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

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Description

Bendazol is a hypotensive drug which can also enhance NO synthase activity in renal glomeruli and collecting tubules.

Bendazol is a member of benzimidazoles.

Dibazole Basic Attributes

Molecular Weight：

208.26

Exact Mass：

208.26

EC Number：

210-703-6

UNII：

26601THN1D

NSC Number：

631632|60020

DSSTox ID：

DTXSID80211157

HScode：

2933990090

Characteristics

PSA：

28.7

XLogP3：

3.2

Appearance：

White or almost white crystalline powder

Density：

1.14 g/cm³ @ Temp: 298.15 °C

Melting Point：

187 °C

Boiling Point：

453.5ºC at 760 mmHg

Flash Point：

252.1±9.3 °C

Refractive Index：

1.680

Water Solubility：

>31.2 [ug/mL]

Toxicity：

Oral-Mouse LD50: 100 mg/kg; Abdominal cavity-mouse LD50: 240 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Safety Information

Hazard category：

IRRITANT

Storage features：

Ventilated, low temperature and dry; stored separately from food materials in warehouse

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons. (See all compounds classified as Interferon Inducers.)|A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)

MeSH Entry Terms：

2-benzylbenzimidazole

Dibazole Use and Manufacturing

It can relax blood vessels, lower blood pressure, relieve smooth muscle spasm and stimulate the spinal cord. Used for hypertension, angina pectoris, toxemia of pregnancy, gastrointestinal spasm, sequelae of poliomyelitis, peripheral facial paralysis, etc.

Computed Properties

Molecular Weight:208.26
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:208.100048391
Monoisotopic Mass:208.100048391
Topological Polar Surface Area:28.7
Heavy Atom Count:16
Complexity:223
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

o-Phenylenediamine

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Dibazole Hydrochlorothiazide Capsules
Ingredients	Dibazole, promethazine hydrochloride, chloroquine phosphate, guanidine sulfate, vitamin B6, potassium chloride, reserpine, chlordiazepoxide, hydrochlorothiazide, calcium lactate, vitamin B1, magnesium trisilicate.
Specifications	Compound
Manufacturer	Shaanxi Bai LU Pharmaceutical Co., Ltd.

Compound Dibazole Hydrochlorothiazide Capsules
Ingredients	Dibazole, promethazine hydrochloride, chloroquine phosphate, guanidine sulfate, vitamin B6, potassium chloride, reserpine, chlordiazepoxide, hydrochlorothiazide, calcium lactate, vitamin B1, magnesium trisilicate.
Indication	1. Guanidine sulfate: (1) When used with ethanol, barbiturates, and sleeping pills, it may aggravate orthostatic hypotension. (2) When used with amphetamine or other appetite suppressants, phenothiazines, tricyclic antidepressants, etc., the orthostatic hypotensive effect is weakened. (3) When used with hypoglycemic drugs, it can enhance the hypoglycemic effect and the dose must be adjusted. (4) When used with nonsteroidal anti-inflammatory analgesics, the antihypertensive effect of this product is weakened because the former may inhibit renal synthesis of prostaglandins and cause water and sodium retention. (5) When used with other antihypertensive drugs such as reserpine, α or β blockers, it can increase orthostatic hypotension. It is generally not recommended to use it with minoxidil. (6) When used with sympathomimetic drugs, the antihypertensive effect of this product is weakened and the pressor effect of sympathomimetic drugs is enhanced. The use of metaraminol with this product may cause hypertensive crisis. 2. Promethazine hydrochloride
Specifications	Compound
Manufacturer	Fujian Yannian Pharmaceutical Co., Ltd.

Compound Dibazole Hydrochlorothiazide Capsules
Ingredients	Dibazole, promethazine hydrochloride, chloroquine phosphate, guanidine sulfate, vitamin B6, potassium chloride, reserpine, chlordiazepoxide, hydrochlorothiazide, calcium lactate, vitamin B1, magnesium trisilicate.
Indication	1. Guanidine sulfate: (1) When used with ethanol, barbiturates, and sleeping pills, it may aggravate orthostatic hypotension. (2) When used with amphetamine or other appetite suppressants, phenothiazines, tricyclic antidepressants, etc., the orthostatic hypotensive effect is weakened. (3) When used with hypoglycemic drugs, it can enhance the hypoglycemic effect and the dose must be adjusted. (4) When used with nonsteroidal anti-inflammatory analgesics, the antihypertensive effect of this product is weakened because the former may inhibit renal synthesis of prostaglandins and cause water and sodium retention. (5) When used with other antihypertensive drugs such as reserpine, α or β blockers, it can increase orthostatic hypotension. It is generally not recommended to use it with minoxidil. (6) When used with sympathomimetic drugs, the antihypertensive effect of this product is weakened and the pressor effect of sympathomimetic drugs is enhanced. The use of metaraminol with this product may cause hypertensive crisis. 2. Promethazine hydrochloride
Specifications	0.25g
Manufacturer	Xi'an Tianyi Qinkun Pharmaceutical Co., Ltd.

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