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Vitamin K4

Vitamin K4 structure

CAS No:
573-20-6
Formula:
C15H14O4
Chemical Name:
Vitamin K4
Synonyms:
1,4-Naphthalenediol,2-methyl-,1,4-diacetate;1,4-Naphthalenediol,2-methyl-,diacetate;Vitamin K4;Davitamon-K;1,4-Diacetoxy-2-methylnaphthalene;Kapilin;Kapilon;Kappaxan;Kativ powder;Kayvite;Menadiol diacetate;2-Methyl-1,4-naphthohydroquinone diacetate;Prokayvit Oral;Vitamin K diacetate;Vitavel K;Acetomenaphthone;Adaprin;Pafavit;Davitamon-K-oral;Kapathrom;2-Methyl-1,4-naphthoquinol diacetate;NSC 403062;Acetomenaphtone
Categories:
Active Pharmaceutical Ingredients > Vitamins and Minerals Medicines

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Description

Vitamin K4 is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system.

Solid

Acetomenaphthone is a member of naphthalenes.

Vitamin K4 Basic Attributes

Molecular Weight：

258.27

Exact Mass：

258.27

EC Number：

209-352-1

UNII：

DWG8UZD9HT

NSC Number：

403062

DSSTox ID：

DTXSID4046236

Characteristics

PSA：

52.6

XLogP3：

Appearance：

Solid

Density：

1.2±0.1 g/cm3

Melting Point：

113 °C

Boiling Point：

388.9°C at 760 mmHg

Flash Point：

195.1±23.0 °C

Refractive Index：

1.580

Collision Cross Section：

157.2 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]

Safety Information

Transport codes：

NONH for all modes of transport

RTECS Number：

QJ5250000

Precautionary statement(s)：

P280-P305 + P351 + P338 + P310

Hazard Statements：

H318

GHS Classification：

|Danger|H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]|P280, P305+P351+P338, and P310|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory.

Vitamin K4 Use and Manufacturing

2-methyl-l, 4-naphthoquinone (1) (20.0 g) was dissolved in ethyl acetate (200 g). Acetic anhydride (29.65 g), DMAP (1.42 g) and Pd/C (0.6 g) were added. The mixture was stirred at room temperature under hydrogen overnight. Pd/ C was filtered out and the filtered liquor was washed with brine. The organic layer was concentrating and recrystallized in water (60 g) and IPA (80 g) solution, thereby obtaining 28.0 g of the title compound as white crystals (yield: 84.2percent, HPLC purity: 99.8percent). The compound was characterized by 'H-NMR: δ 2.27, s, 3H; 2.46, s, 3H; 2.50, s, 3H; 7.27, s, 1H; 7.55-7.62, m, 2H; 7.85-7.89, d, 2H.2-methyl-l, 4-naphthoquinone (1) (20.0 g) was dissolved in ethyl acetate (200 g). Acetic anhydride (29.65 g), DMAP (1.42 g) and Pd/C (0.6 g) were added. The mixture was stirred at room temperature under hydrogen overnight. Pd/ C was filtered out and the filtered liquor was washed with brine. The organic layer was concentrating and recrystallized in water (60 g) and IPA (80 g) solution, thereby obtaining 28.0 g of the title compound as white crystals (yield: 84.2percent, HPLC purity: 99.8percent).

Computed Properties

Molecular Weight:258.27
XLogP3:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:258.08920892
Monoisotopic Mass:258.08920892
Topological Polar Surface Area:52.6
Heavy Atom Count:19
Complexity:352
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Methylnaphthalene

Sodium acetate trihydrate

Drug Function and Efficacy

Vitamin K is a necessary substance for the liver to synthesize coagulation factors II, VII, IX, and X. Vitamin K deficiency can cause synthesis disorders of these coagulation factors, clinically manifested by bleeding tendency and prolonged prothrombin time. The exact mechanism by which vitamin K promotes the synthesis of factors II, VII, IX, and X has not yet been elucidated.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Menadione Acetate Tablets
Ingredients	The main ingredients of this product are: Menadione Acetate
Indication	Oral anticoagulants such as dicoumarol can interfere with the metabolism of vitamin K. When the two drugs are used together, their effects cancel each other out. Salicylates, sulfonamides, quinidine, etc. can also affect the effects of vitamin K.
Specifications	2mg
Manufacturer	Di'ao Group Chengdu Pharmaceutical Co., Ltd.

Menadione Acetate Tablets
Ingredients	The main ingredients of this product are: Menadione Acetate
Indication	Oral anticoagulants such as dicoumarol can interfere with the metabolism of vitamin K. When the two drugs are used together, their effects cancel each other out. Salicylates, sulfonamides, quinidine, etc. can also affect the effects of vitamin K.
Specifications	4mg
Manufacturer	Reyoung Pharmaceutical Co., Ltd.

Menadione Acetate Tablets
Ingredients	The chemical name of this product is: 2-methyl-1,4-naphthalene diphenol diacetate.
Indication	Oral anticoagulants such as dicoumarol can interfere with the metabolism of vitamin K. When the two drugs are used together, their effects cancel each other out. Salicylates, sulfonamides, quinidine, etc. can also affect the effects of vitamin K.
Specifications	4mg
Manufacturer	Shanxi Lijiu Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Zhejiang Cheng Yi Pharmaceutical Co., Ltd.

China
Active
Anhui Wanhe Pharmaceutical Co., Ltd.

China
Active
Sichuan Ren An Pharmaceutical Co., Ltd.

China
Active

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