6-Chloro-5-methoxy-4-pyrimidinamine
-
6-Chloro-5-methoxy-4-pyrimidinamine
structure -
-
CAS No:
5018-41-7
-
Formula:
C5H6ClN3O
-
Chemical Name:
6-Chloro-5-methoxy-4-pyrimidinamine
-
Synonyms:
4-Pyrimidinamine,6-chloro-5-methoxy-;Pyrimidine,4-amino-6-chloro-5-methoxy-;6-Chloro-5-methoxy-4-pyrimidinamine;4-Amino-5-methoxy-6-chloropyrimidine;4-Amino-6-chloro-5-methoxypyrimidine;6-Chloro-5-methoxypyrimidin-4-amine
- Categories:
-
CAS No:
6-Chloro-5-methoxy-4-pyrimidinamine Basic Attributes
159.57
159.57
225-700-5
XTV46J7E54
DTXSID50198229
2933599090
Safety Information
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
6-Chloro-5-methoxy-4-pyrimidinamine Use and Manufacturing
A mixture of 4, 6-dichloro-5-methoxypyrimidine (5.0g, 28.1mmol), 30percent 10 aqueous ammonia (45mL), and n-butanol (15mL) was heated at 85°C in a sealed tube for 8h. The reaction mixture was then concentrated under reduced pressure and suspended in brine (150mL). The white precipitate was filtered off and the fliter cake was recrystallized from EtOH to give the title compound as an off-white solid. Yield (4.1g, 90percent). Starting material 1 (4, 6-dichloro-5-methoxypyrimidine 5.0 g, 28.1 mmol), 30percent aqueous ammonia solution (45 mL), 15 mLThe n-butanol was added to the sealed tube and reacted at 85 ° C for 8 hours. After cooling to room temperature, the reaction solution was concentrated under reduced pressure to give a white solid.The color solid was dissolved in a suspension with 150 mL of an aqueous solution of sodium chloride and stirred at room temperature for 0.5 hour, followed by suction filtration.The alcohol and diethyl ether were washed to obtain Intermediate 1. The yield was 90percent.Description 16; 4-Amino-6-chloro-5-methoxypyrimidine; A mixture of 4, 6-dichloro-5-methoxypyrimidine (5.0 g, 27.9 mmol), 33percent aqueous ammonia (30 ml) and 1'butanol (15 ml) was heated at 90°C in a sealed tube for 2.5 hours. The mixture was allowed to cool and the precipitate removed by filtration, and dried to give the title compound as a white solid (1. 8 g, 40percent). 1H NMR (400 MHz, DMSO-d6) 3.71 (3 H, s), 7.30 (2 H, br s), 7.96 (1 H, s).
Computed Properties
Molecular Weight:159.57
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:159.0199395
Monoisotopic Mass:159.0199395
Topological Polar Surface Area:61
Heavy Atom Count:10
Complexity:113
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 6-Chloro-5-methoxy-4-pyrimidinamine
-
![China]()
CN
8 YRS
Business licensed Certified factoryManufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances ChemicalsInquiryCAS No.: 5018-41-7Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
4 YRS
Business licensed Certified factoryManufactory Supplier of Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides,Organic Intermediates,OLED IntermediatesInquiryCAS No.: 5018-41-7Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamineInquiryCAS No.: 5018-41-7Grade: Industrial GradeContent: 99%
Learn More Other Chemicals
-
(2E)-3-(1-METHYL-1H-PYRROL-2-YL)ACRYLIC ACID
51485-76-8
-
Benadryl N-oxide hydrochloride
13168-00-8
-
6-CHLORO-3-IODO-IMIDAZO[1,2-A]PYRIDINE
885275-59-2
-
(2-Bromophenyl)diphenylphosphine Formula
62336-24-7
-
1-Morpholinocyclopentene Formula
936-52-7
-
4-[2-(Boc-amino)ethoxy]-benzoic acid Formula
168892-66-8
-
3-amino-5-bromopyridine-2-carboxylic acid Structure
870997-85-6
-
2-Amino-6-methylpyridine Structure
1824-81-3
-
What is 3-Bromo-2-methylthiophene
30319-05-2
-
What is THIOPHEN-2-YLMETHYL-PHOSPHONICACIDDIETHYLESTER
2026-42-8
6-Chloro-5-methoxy-4-pyrimidinamine
SDSRequest for Quotation