Glycine ethyl ester hydrochloride
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Glycine ethyl ester hydrochloride
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CAS No:
623-33-6
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Formula:
C4H9NO2.ClH
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Chemical Name:
Glycine ethyl ester hydrochloride
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Synonyms:
Glycine,ethyl ester,hydrochloride (1:1);Glycine,ethyl ester,hydrochloride;Ethyl glycinate hydrochloride;Glycine hydrochloride ethyl ester;Ethyl aminoacetate hydrochloride;Glycine ethyl ester monohydrochloride;Ethyl 2-aminoacetate hydrochloride;Glycine ethyl ester hydrochloride salt;Aminoacetic acid ethyl ester hydrochloride;281: PN: US20050107325 PAGE: 127 claimed protein;Glycine ethyl ether hydrochloride;279: PN: US20070105806 PAGE: 26 claimed protein;(2-Ethoxy-2-oxoethyl)ammonium chloride;27: PN: WO2010042547 PAGE: 47 claimed protein;L-Glycine ether ester hydrochloride;Glycine ethyl ester hydrochloride;2-Ethoxy-2-oxoethan-1-aminium chloride;69808-67-9;89004-43-3;2365110-08-1
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CAS No:
Glycine ethyl ester hydrochloride Basic Attributes
139.58
154.050903
3594034
210-787-4
3044
DTXSID8052300
29224995
Characteristics
52.3
1.01050
White Crystalline Powder
1.371 g/cm3
145.2 °C
109.5ºC at 760 mmHg
H2O: >1000 g/L (20 ºC)
Store at RT.
Safety Information
NONH for all modes of transport
3
41-36/37/38
26-39-24/25-37/39
MC0525000
Xi
Stable under normal temperatures and pressures.
P280-P305 + P351 + P338
H318
|Danger|H318 (92.98%): Causes serious eye damage [Danger Serious eye damage/eye irritation]|P280, P305+P351+P338, and P310|Aggregated GHS information provided by 64 companies from 5 notifications to the ECHA C&L Inventory.
Glycine ethyl ester hydrochloride Use and Manufacturing
Can be prepared with glycine or chloroacetic acid as raw materials. It is described as follows. Glycine is used as the raw material method. Dry hydrogen chloride gas is passed into absolute ethanol to make hydrogen chloride ethanol solution, then glycine is added, heated and stirred for esterification, and the reaction temperature is controlled at 80-85°C. After all the glycine is dissolved, stirring A few minutes, while hot, move the reaction solution to the crystallization pot, cool the crystallization, and filter to obtain ethyl glycine hydrochloride. Reaction equation: NH2CH2COOH+C2H5O[HCl]→NH2CH2COOC2H5·HCl can also be added to the reactor with stirring glycine and absolute ethanol, heated to 60 ℃, through the introduction of hydrogen chloride gas, hydrogen chloride until the reactants are completely dissolved, continue After passing hydrogen chloride to recrystallization, it is the end point. The reaction solution is transferred to the crystallization pot, while stirring, the crystal is cooled and filtered, washed with absolute ethanol, and dried to obtain ethyl glycine hydrochloride. Chloroacetic acid is used as the raw material method. Chloroacetic acid, urotropine and absolute ethanol are added to the reactor. At 45℃, ammonia gas is passed to make pH=8～8.5. The rate of ammonia gas is controlled to maintain the reaction temperature at Between 40 and 65°C, after the ammonia gas has been passed through, the reaction is held at 65°C for 1 hour, then the temperature is reduced to 30°C, and the hydrogen chloride-anhydrous ethanol solution is added dropwise. After the dropwise addition, react at 70℃ for 2h, then filter hot at 62～65℃ to separate the ammonium chloride crystals. The filtrate is placed in a crystallization pot, cooled to 10℃, crystallized while stirring, the crystals are filtered, Dry to give ethyl glycine hydrochloride. Reaction equation: ClCH2COOH+NH3[ethanol]→NH2CH2COOH[C2H5OH]→[HCl]NH2CH2COOH·HCl
A Glycine (G615990) ester used as parakeratosis inhibitor and external composition for skin.
Glycine, ethyl ester, hydrochloride (1:1): ACTIVE
Computed Properties
Molecular Weight:139.58
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:139.0400063
Monoisotopic Mass:139.0400063
Topological Polar Surface Area:52.3
Heavy Atom Count:8
Complexity:62.7
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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Glycine ethyl ester hydrochloride
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