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Trimecaine

Trimecaine structure

CAS No:
616-68-2
Formula:
C15H24N2O
Chemical Name:
Trimecaine
Synonyms:
Acetamide,2-(diethylamino)-N-(2,4,6-trimethylphenyl)-;Acetanilide,2-(diethylamino)-2′,4′,6′-trimethyl-;2-(Diethylamino)-N-(2,4,6-trimethylphenyl)acetamide;ω-Diethylaminoacetylaminomesitylene;N-(Diethylaminoacetyl)-2,4,6-trimethylaniline;2-(Diethylamino)-2′,4′,6′-trimethylacetanilide;Diethylglycinemesidide;Mesidicaine;Trimecain;Trimecaine;Justecaina;Mesdicain;Mesokain;91484-70-7
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

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Description

Trimecaine is an amino acid amide.|Acetanilide derivative used as a local anesthetic.

Trimecaine Basic Attributes

Molecular Weight：

248.36

Exact Mass：

248.36

EC Number：

210-487-3

UNII：

IN1233R0JO

DSSTox ID：

DTXSID6048410

Characteristics

PSA：

32.3

XLogP3：

2.82

Appearance：

white crystalline powder

Density：

1.0±0.1 g/cm3

Melting Point：

44 °C

Boiling Point：

187 °C

Flash Point：

171.7±24.6 °C

Refractive Index：

1.544

Toxicity：

LD50 s.c. in mice: 295 mg/kg (Borovansky)

Drug Information

MeSH：

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

MeSH Entry Terms：

Mesocaine

Computed Properties

Molecular Weight:248.36
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:248.188863393
Monoisotopic Mass:248.188863393
Topological Polar Surface Area:32.3
Heavy Atom Count:18
Complexity:251
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes